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Claus Munck Petersen

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. / Jansen, Pernille; Giehl, Klaus; Nyengaard, Jens R; Teng, Kenneth; Lioubinski, Oleg; Sjoegaard, Susanne S; Breiderhoff, Tilman; Gotthardt, Michael; Lin, Fuyu; Eilers, Andreas; Petersen, Claus M; Lewin, Gary R; Hempstead, Barbara L; Willnow, Thomas E; Nykjaer, Anders.

In: Nature Neuroscience, Vol. 10, No. 11, 2007, p. 1449-57.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jansen, P, Giehl, K, Nyengaard, JR, Teng, K, Lioubinski, O, Sjoegaard, SS, Breiderhoff, T, Gotthardt, M, Lin, F, Eilers, A, Petersen, CM, Lewin, GR, Hempstead, BL, Willnow, TE & Nykjaer, A 2007, 'Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.', Nature Neuroscience, vol. 10, no. 11, pp. 1449-57. https://doi.org/10.1038/nn2000

APA

Jansen, P., Giehl, K., Nyengaard, J. R., Teng, K., Lioubinski, O., Sjoegaard, S. S., ... Nykjaer, A. (2007). Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience, 10(11), 1449-57. https://doi.org/10.1038/nn2000

CBE

Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A. 2007. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience. 10(11):1449-57. https://doi.org/10.1038/nn2000

MLA

Vancouver

Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience. 2007;10(11):1449-57. https://doi.org/10.1038/nn2000

Author

Jansen, Pernille ; Giehl, Klaus ; Nyengaard, Jens R ; Teng, Kenneth ; Lioubinski, Oleg ; Sjoegaard, Susanne S ; Breiderhoff, Tilman ; Gotthardt, Michael ; Lin, Fuyu ; Eilers, Andreas ; Petersen, Claus M ; Lewin, Gary R ; Hempstead, Barbara L ; Willnow, Thomas E ; Nykjaer, Anders. / Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. In: Nature Neuroscience. 2007 ; Vol. 10, No. 11. pp. 1449-57.

Bibtex

@article{9a3afd80d62a11dcbc43000ea68e967b,
title = "Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.",
abstract = "Neurotrophins are essential for development and maintenance of the vertebrate nervous system. Paradoxically, although mature neurotrophins promote neuronal survival by binding to tropomyosin receptor kinases and p75 neurotrophin receptor (p75(NTR)), pro-neurotrophins induce apoptosis in cultured neurons by engaging sortilin and p75(NTR) in a death-signaling receptor complex. Substantial amounts of neurotrophins are secreted in pro-form in vivo, yet their physiological significance remains unclear. We generated a sortilin-deficient mouse to examine the contribution of the p75(NTR)/sortilin receptor complex to neuronal viability. In the developing retina, Sortilin 1 (Sort1)(-/-) mice showed reduced neuronal apoptosis that was indistinguishable from that observed in p75(NTR)-deficient (Ngfr(-/-)) mice. To our surprise, although sortilin deficiency did not affect developmentally regulated apoptosis of sympathetic neurons, it did prevent their age-dependent degeneration. Furthermore, in an injury protocol, lesioned corticospinal neurons in Sort1(-/-) mice were protected from death. Thus, the sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging. Udgivelsesdato: 2007-Nov",
keywords = "Aging, Animals, Animals, Newborn, Apoptosis, Brain Injuries, Cell Count, Cells, Cultured, Embryo, Mammalian, Gene Expression Regulation, Developmental, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins, Neurons, Receptors, Nerve Growth Factor, Retina, Signal Transduction, Superior Cervical Ganglion, Time Factors, Tyrosine 3-Monooxygenase",
author = "Pernille Jansen and Klaus Giehl and Nyengaard, {Jens R} and Kenneth Teng and Oleg Lioubinski and Sjoegaard, {Susanne S} and Tilman Breiderhoff and Michael Gotthardt and Fuyu Lin and Andreas Eilers and Petersen, {Claus M} and Lewin, {Gary R} and Hempstead, {Barbara L} and Willnow, {Thomas E} and Anders Nykjaer",
year = "2007",
doi = "10.1038/nn2000",
language = "English",
volume = "10",
pages = "1449--57",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

AU - Jansen, Pernille

AU - Giehl, Klaus

AU - Nyengaard, Jens R

AU - Teng, Kenneth

AU - Lioubinski, Oleg

AU - Sjoegaard, Susanne S

AU - Breiderhoff, Tilman

AU - Gotthardt, Michael

AU - Lin, Fuyu

AU - Eilers, Andreas

AU - Petersen, Claus M

AU - Lewin, Gary R

AU - Hempstead, Barbara L

AU - Willnow, Thomas E

AU - Nykjaer, Anders

PY - 2007

Y1 - 2007

N2 - Neurotrophins are essential for development and maintenance of the vertebrate nervous system. Paradoxically, although mature neurotrophins promote neuronal survival by binding to tropomyosin receptor kinases and p75 neurotrophin receptor (p75(NTR)), pro-neurotrophins induce apoptosis in cultured neurons by engaging sortilin and p75(NTR) in a death-signaling receptor complex. Substantial amounts of neurotrophins are secreted in pro-form in vivo, yet their physiological significance remains unclear. We generated a sortilin-deficient mouse to examine the contribution of the p75(NTR)/sortilin receptor complex to neuronal viability. In the developing retina, Sortilin 1 (Sort1)(-/-) mice showed reduced neuronal apoptosis that was indistinguishable from that observed in p75(NTR)-deficient (Ngfr(-/-)) mice. To our surprise, although sortilin deficiency did not affect developmentally regulated apoptosis of sympathetic neurons, it did prevent their age-dependent degeneration. Furthermore, in an injury protocol, lesioned corticospinal neurons in Sort1(-/-) mice were protected from death. Thus, the sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging. Udgivelsesdato: 2007-Nov

AB - Neurotrophins are essential for development and maintenance of the vertebrate nervous system. Paradoxically, although mature neurotrophins promote neuronal survival by binding to tropomyosin receptor kinases and p75 neurotrophin receptor (p75(NTR)), pro-neurotrophins induce apoptosis in cultured neurons by engaging sortilin and p75(NTR) in a death-signaling receptor complex. Substantial amounts of neurotrophins are secreted in pro-form in vivo, yet their physiological significance remains unclear. We generated a sortilin-deficient mouse to examine the contribution of the p75(NTR)/sortilin receptor complex to neuronal viability. In the developing retina, Sortilin 1 (Sort1)(-/-) mice showed reduced neuronal apoptosis that was indistinguishable from that observed in p75(NTR)-deficient (Ngfr(-/-)) mice. To our surprise, although sortilin deficiency did not affect developmentally regulated apoptosis of sympathetic neurons, it did prevent their age-dependent degeneration. Furthermore, in an injury protocol, lesioned corticospinal neurons in Sort1(-/-) mice were protected from death. Thus, the sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging. Udgivelsesdato: 2007-Nov

KW - Aging

KW - Animals

KW - Animals, Newborn

KW - Apoptosis

KW - Brain Injuries

KW - Cell Count

KW - Cells, Cultured

KW - Embryo, Mammalian

KW - Gene Expression Regulation, Developmental

KW - Membrane Glycoproteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Nerve Tissue Proteins

KW - Neurons

KW - Receptors, Nerve Growth Factor

KW - Retina

KW - Signal Transduction

KW - Superior Cervical Ganglion

KW - Time Factors

KW - Tyrosine 3-Monooxygenase

U2 - 10.1038/nn2000

DO - 10.1038/nn2000

M3 - Journal article

C2 - 17934455

VL - 10

SP - 1449

EP - 1457

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 11

ER -