Claus Munck Petersen

Rapid immunoelectrophoretic assay for detection of serum antibodies to Aspergillus fumigatus catalase in patients with pulmonary aspergillosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

A rapid immunoelectrophoretic assay was developed to detect antibodies to Aspergillus fumigatus catalase. The method's diagnostic sensitivity for pulmonary aspergillosis was 88% (72-97%, 95% confidence limits) in 33 patients presenting with either aspergilloma or Aspergillus lung infiltrate. The diagnostic specificity was 94% (90-97%) as judged from 191 patients with other infiltrative lung diseases, including infections and neoplasia. None of the 185 healthy subjects had catalase antibodies. The highest titres (ranging up to 256) were found in aspergillosis patients with cavitary lesions. Catalase antibody titres increased in two patients with concomitant development of lung cavities and mycetomas. In patients with resected or stable Aspergillus lung disorders catalase antibody titres declined by less than one dilution step per year.
Original languageEnglish
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume4
Issue3
Pages (from-to)299-303
Number of pages5
ISSN0934-9723
Publication statusPublished - 1985

    Research areas

  • Adolescent, Adult, Aged, Animals, Antibodies, Fungal, Aspergillosis, Aspergillosis, Allergic Bronchopulmonary, Aspergillus fumigatus, Catalase, Female, Humans, Immunoelectrophoresis, Lung Diseases, Fungal, Male, Middle Aged, Mycetoma, Rabbits, Time Factors

See relations at Aarhus University Citationformats

ID: 43830183