Claus Munck Petersen

Identification and characterization of urokinase receptors in natural killer cells and T-cell-derived lymphokine activated killer cells

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Fluorescence-activated cell scanning analysis of human blood cells revealed novel urokinase receptors in large granular lymphocytes and a small subset of T-cells (CD3+). Culturing of T-cells with interleukin-2 to generate CD3+ lymphokine-activated killer cells caused a large increase in urokinase binding, suggesting that the urokinase receptor is an activation antigen. The receptor in lymphocytes was similar to that in monocytes with regard to size, affinity and ligand specificity, but did not mediate degradation of urokinase-inhibitor complexes. It is suggested that lymphocyte-bound pro-urokinase is activated, e.g. by the human T-cell-specific serine proteinase, HuTSP-1, and thereby starts a cascade of plasminogen activation important for extravasation of the cells.
Original languageEnglish
JournalF E B S Letters
Pages (from-to)13-7
Number of pages5
Publication statusPublished - 1992

    Research areas

  • Flow Cytometry, Humans, Killer Cells, Lymphokine-Activated, Killer Cells, Natural, Neutrophils, Receptors, Cell Surface, Receptors, Urokinase Plasminogen Activator, T-Lymphocytes, Urokinase-Type Plasminogen Activator

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