Claus Munck Petersen

HLA-DP and bone marrow transplantation: DP-incompatibility and severe acute graft versus host disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • N Odum
  • ,
  • P Platz
  • ,
  • B K Jakobsen
  • ,
  • C M Petersen
  • N Jacobsen, Denmark
  • J Møller, Denmark
  • Lars P. Ryder
  • ,
  • L Lamm
  • ,
  • Anja Svejgaard
Thirteen recipients of HLA-haploidentical, DR compatible bone marrow (BM) and the corresponding BM donors were HLA-DP typed using primed lymphocyte typing (PLT). Severe acute GVHD (greater than or equal to grade 2) developed within 3 months after BM-transplantation in all of eight recipients of DP incompatible BM, but in none of five recipients of DP-compatible BM. This difference was highly significant (p less than 0.001, Fisher's exact test). Moreover, severe acute GVHD was significantly increased in recipients of haploidentical, DR compatible, but DP incompatible BM as compared to severe acute GVHD in 88 recipients of HLA-identical BM (p less than 0.0001). In contrast, there was no difference in acute GVHD between recipients of haploidentical, DR and DP compatible BM and recipients of HLA-identical BM. The data presented here provide strong evidence for the first time that HLA-DP antigens play a role as transplantation antigens.
Original languageEnglish
JournalHLA
Volume30
Issue5
Pages (from-to)213-6
Number of pages4
ISSN2059-2302
Publication statusPublished - 1987

    Research areas

  • Bone Marrow Transplantation, Graft vs Host Disease, HLA-D Antigens, HLA-DP Antigens, Haplotypes, Humans, Transplantation Immunology

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