Claus Munck Petersen

ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE

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DOI

OBJECTIVE: The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice.

METHODS: We measured free T4, thyroid-stimulating hormone (TSH) and Tg serum levels and studied thyroid morphology in 14 sortilin-deficient (Sort1)(-/-)and 12 wildtype (WT) mice.

RESULTS: Serum free T4 levels did not differ between Sort1(-/-)and WT females but were significantly lower in Sort1(-/-)males compared with WT (P = .0424). Neither serum TSH nor Tg levels differed between Sort1(-/-)and WT mice, regardless of sex. On the same line, no thyroid histology differences were observed.

CONCLUSION: Our findings seem to exclude a role of sortilin in thyroid hormone secretion, although it is possible that the absence of sortilin may result in a thyroid phenotype if combined with other molecular defects of thyroid hormone synthesis and secretion or under iodine deficiency.

ABBREVIATIONS: T4 = thyroxine Sort1 = Sortilin 1 Tg = thyroglobulin TSH = thyroid-stimulating hormone WT = wild type.

Original languageEnglish
JournalEndocrine Practice
Volume21
Issue9
Pages (from-to)981-985
Number of pages5
ISSN1530-891X
DOIs
Publication statusPublished - Sep 2015

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