Cindrilla Chumduri

Research output

Research output per year 2013 2018 2021 2024

• 18 Journal article
• 4 Preprint
• 2 Book chapter
• 1 Patent

Research output per year

Research output per year

Search results

• 2024

  Culturing and Differentiation of Patient-derived Ectocervical Epithelial Stem Cells using Air-Liquid Interphase and Matrigel Scaffold.

  Kumar Gurumurthy, R., Kumar, N. & Chumduri, C., 2024, Epithelial Cell Culture: methods and protocols. Baratta, M. (ed.). New York: Humana Press, Vol. 2. p. 109-122 (Methods in Molecular Biology).

  Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review

• Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis

  Kumar, N., Prakash, P. G., Wentland, C., Kurian, S. M., Jethva, G., Brinkmann, V., Mollenkopf, H. J., Krammer, T., Toussaint, C., Saliba, A. E., Biebl, M., Jürgensen, C., Wiedenmann, B., Meyer, T. F., Gurumurthy, R. K. & Chumduri, C., Apr 2024, In: Nature Communications. 15, 1, 3064.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Single Cell Analysis 100%
  • Dynamics 100%
  • Fibroblast 100%
  • Gastroesophageal Junction 100%
  • Single-Cell Analysis 100%
• 2023

  γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

  Dong, J., Holthaus, D., Peters, C., Koster, S., Ehsani, M., Quevedo-Olmos, A., Berger, H., Zarobkiewicz, M., Mangler, M., Kumar Gurumurthy, R., Hedemann, N., Chumduri, C., Kabelitz, D. & Meyer, T. F., 26 Jun 2023, 25 p.

  Research output: Working paper/Preprint › Preprint
• 2022

  Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

  Koster, S., Kumar Gurumurthy, R., Kumar, N., Ganish Prakash, P., Dhanraj, J., Bayer, S., Berger, H., Kurian, S. M., Drabkina, M., Mollenkopf, H.-J., Goosmann, C., Brinkmann, V., Nagel, Z., Mangler, M., Meyer, T. F. & Chumduri, C., 24 Feb 2022, In: Nature Communications. 13, 15 p., 1030.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Uterine Cervix Mucosa 100%

• Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection

  Kumar Gurumurthy, R., Koster, S., Kumar, N., Meyer, T. F. & Chumduri, C., 11 May 2022, In: Nature Protocols (Online). 17, p. 1658–1690 33 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Stratified Squamous Epithelium 100%

• Single object profiles regression analysis (SOPRA): a novel method for analyzing high-content cell-based screens

  Kumar Gurumurthy, R., Pleissner, K.-P., Chumduri, C., Meyer, T. F. & Mäurer, A. P., 21 Oct 2022, In: BMC Bioinformatics . 23, 16 p., 440 (2022.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • RNA Interference 100%
  • Small Interfering RNA 100%
  • Population Dynamics 100%
  • Cell Cycle 100%
  • Cell Cycle Progression 100%
• 2021

  Cervical Cancer Organoids

  Kumar Gurumurthy, R. (Inventor), Chumduri, C. (Inventor) & Meyer, T. F. (Inventor), 18 Nov 2021, IPC No. C12N 5/071, G01N 33/50, G01N 33/574, Patent No. US2021355450 (A1), 11 Oct 2019, Priority date 15 Oct 2018, Priority No. EP20180200408

  Research output: Patent

  Open Access

• Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

  Koster, S., Kumar Gurumurthy, R., Berger, H., Drabkina, M., Mollenkopf, H.-J., Goosmann, C., Brinkmann, V., Nagel, Z., Mangler, M., Meyer, T. F. & Chumduri, C., 15 Apr 2021, 46 p.

  Research output: Working paper/Preprint › Preprint

• Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia

  Chumduri, C., Kumar Gurumurthy, R., Berger, H., Dietrich, O., Kumar, N., Koster, S., Brinkmann, V., Hoffmann, K., Drabkina, M., Arampatzi, P., Son, D., Klemm, U., Mollenkopf, H.-J., Herbst, H., Mangler, M., Vogel, J., Saliba, A.-E. & Meyer, T. F., 18 Jan 2021, In: Nature Cell Biology. 23, p. 184–197 14 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Metaplasia 100%
  • Wnt Signaling 100%
  • Homeostasis 100%
  • Stem Cell 50%
  • Columnar Epithelium 33%

• Optimized protocol for isolation of high-quality single cells from the female mouse reproductive tract tissues for single-cell RNA sequencing

  Kumar Gurumurthy, R., Kumar, N. & Chumduri, C., 17 Dec 2021, In: STAR Protocols. 2, 4, 10 p., 100970.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Single-cell RNA Sequencing (scRNA-seq) 100%
  • Reproductive Tract 100%
  • Mouse 100%
  • RNA Sequence 100%
  • High Cell Viability 33%

• Organoids of the Female Reproductive Tract.

  Chumduri, C. & Yayoi Turco, M., Apr 2021, In: Journal of Molecular Medicine. 99, 4, p. 531-553 3 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Organoid 100%
  • Female Reproductive Tract 100%
  • Organoids 100%
  • In Vitro 50%
  • Infection 25%

• Spatial analysis of organ-wide RNA, protein expression, and lineage tracing in the female mouse reproductive tract

  Kumar Gurumurthy, R., Kumar, N. & Chumduri, C., 17 Nov 2021, In: STAR Protocols. 2, 4, 21 p., 100969.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Lineage Tracing 100%
  • Single-molecule RNA 100%
  • Lineages 100%
  • Protein Expression 100%
  • Mouse 100%

• Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironment

  Kumar, N., Kumar Gurumurthy, R., Ganish Prakash, P., Kurian, S. M., Wentland, C., Brinkmann, V., Mollenkopf, H.-J., Krammer, T., Toussaint, C., Saliba, A.-E., Biebl, M., Juergensen, C., Wiedenmann, B., Meyer, T. F. & Chumduri, C., 6 Aug 2021, 43 p.

  Research output: Working paper/Preprint › Preprint
• 2020

  Organoide des weiblichen Reproduktionstraktes

  Chumduri, C. & Yayoi Turco, M., 2020, Organoide: Ihre Bedeutung für Forschung, Medizin und Gesellschaft. Bartfeld, S., Schickl, H., Alev, C., Koo, B.-K., Pichl, A., Osterheider, A. & Marx-Stölting, L. (eds.). Nomos Verlagsgesellschaft mbH und Co. KG, p. 131-138 8 p.

  Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
• 2019

  Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells

  K. Zadora, P., Chumduri, C., Imami, K., Berger, H., Mi, Y., Selbach, M., Meyer, T. F. & Kumar Gurumurthy, R., 29 Jan 2019, In: Cell Reports. 26, 5, p. 1286-1302 17 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
• 2018

  Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling

  Mi, Y., Kumar Gurumurthy, R., K. Zadora, P., Meyer, T. F. & Chumduri, C., 6 Nov 2018, In: mBio (Online). 9, 6, 12 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

• Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection

  Rother, M., Gonzalez, E., Teixeira da Costa, A. R., Wask, L., Gravenstein, I., Pardo, M., Pietzke, M., Kumar Gurumurthy, R., Angermann, J., Laudeley, R., Glage, S., Meyer, M., Chumduri, C., Kempa, S., Dinkel , K., Unger, A., Klebl, B., Klos, A. & Meyer, T. F., 26 Apr 2018, In: Cell Host & Microbe. 23, 5, p. 661-671 11 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

• Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53

  Müller, A., Gillissen, B., Richter, A., Chumduri, C., T. Daniel, P. & W. Scholz, C., 7 Mar 2018, In: Cell Death & Disease. 9, 14 p., 384 (2018).

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

• Transition of Wnt signaling microenvironment delineates the squamo-columnar junction and emergence of squamous metaplasia of the cervix

  Chumduri, C., Kumar Gurumurthy, R., Berger, H., Koster, S., Brinkmann, V., Klemm, U., Mollenkopf, H.-J., Herbst, H., Mangler, M. & Meyer, T. F., 2018, 40 p.

  Research output: Working paper/Preprint › Preprint
• 2016

  Subversion of host genome integrity by bacterial pathogens

  Chumduri, C., Kumar Gurumurthy, R., Zietlow, R. & Meyer, T. F., 18 Aug 2016, In: Nature Reviews Molecular Cell Biology. 17, 19, p. 659-673 15 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
• 2014

  Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.

  Chumduri, C., Gillissen, B., Richter, A., Richter, A., Milojkovic, A., Overkamp, T., Müller, A., Pott, C. & T. Daniel, P., 30 Dec 2014, In: Journal of Molecular Medicine. 93, 5, p. 559–572 14 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

• Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.

  Kumar Gurumurthy, R., Chumduri, C., Karlas, A., Kimmig, S., Gonzalez, E., Machuy, N., Rudel, T. & Meyer, T. F., 13 Aug 2014, In: Molecular Microbiology. 94, 1, p. 186-201 16 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
• 2013

  Chlamydia Infection Promotes Host DNA Damage and Proliferation but Impairs the DNA Damage Response

  Chumduri, C., Kumar Gurumurthy, R., K. Zadora, P. & Meyer, T. F., 12 Jun 2013, In: Cell Host & Microbe. 13, 6, p. 746-758 13 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

• Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.

  Müller, A., Zang, C., Chumduri, C., Dörken, B., T. Daniel, P. & W. Scholz, C., 12 Apr 2013, In: International Journal of Cancer. 133, 8, p. 1813-1824 12 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

• p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop.

  Milojkovic, A., G. Hemmati, P., Müer, A., Overkamp, T., Chumduri, C., U. Jänicke, R., Gillissen, B. & T. Daniel, P., 17 May 2013, In: International Journal of Cancer. 133, 11, p. 2551-2562 12 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review