Christian Stæhr

2025

Exploring the association between familial hemiplegic migraine genes (CACNA1A, ATP1A2 and SCN1A) with migraine and epilepsy: A UK Biobank exome-wide association study

Staehr, C., Nyegaard, M., Bach, F. W., Rohde, P. D. & Matchkov, V. V., Jan 2025, In: Cephalalgia : an international journal of headache. 45, 1, p. 3331024241306103

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Open Access

Hypoxia and ischemic stroke modify cerebrovascular tone by upregulating endothelial BK(Ca) channels—Lessons from rat, pig, mouse, and human

Staehr, C., Hinkley, V., Matchkov, V. V., Rajanathan, R., Hansen, L. M. B., Eiby, Y., Luque, N., Wright, I., Bjorkman, S. T., Miller, S. M., Grimley, R. S., Dettrick, A., Chand, K., Nguyen, H. L., Jones, N. M., Murphy, T. V. & Sandow, S. L., Apr 2025, In: Acta Physiologica (Print). 241, 4, e70030.

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Open Access

Pharmacological Interventions for the Acute Treatment of Hyperkalaemia: A Systematic Review and Meta-analysis

International Liaison Committee on Resuscitation ILCOR Advanced Paediatric Life Support Task Forces, Mar 2025, In: Resuscitation. 208, p. 110489 110489.

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Open Access

1 Citation (Scopus)

Spatial Transcriptomics and Proteomics Profiling After Ischemic Stroke Reperfusion: Insights Into Vascular Alterations

Hansen, L. M. B., Dam, V. S., Guldbrandsen, H. Ø., Staehr, C., Pedersen, T. M., Kalucka, J. M., Beck, H. C., Postnov, D., Lin, L. & Matchkov, V., 1 Apr 2025, In: Stroke. 56, 4, p. 1036-1047 12 p.

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Open Access

Spinal cord blood flow elevation with systemic vasopressor noradrenaline is partly mediated by vasodilation of spinal arteries due to reduced expression of alpha adrenoreceptors

Entezari, S., Thygesen, M. M., Staehr, C., Melnikova, E., Skov, M., Rajanathan, R., Rasmussen, M., Rasmussen, M. M. & Matchkov, V. V., Mar 2025, In: The spine journal : official journal of the North American Spine Society. 25, 3, p. 609-619 11 p.

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Open Access

1 Citation (Scopus)

2024

Targeting Na,K-ATPase-Src signaling to normalize cerebral blood flow in a murine model of familial hemiplegic migraine

Staehr, C., Guldbrandsen, H. Ø., Homilius, C., Johnsen, L. Ø., Postnov, D., Pedersen, T. M., Pierre, S., Sandow, S. L. & Matchkov, V. V., 4 Dec 2024, (E-pub / Early view) In: Journal of Cerebral Blood Flow and Metabolism. p. 271678X241305562

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2023

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na+,K+-ATPase α2-Isoform

Rajanathan, R., Riera, C. V. I., Pedersen, T. M., Staehr, C., Bouzinova, E. V., Nyengaard, J. R., Thomsen, M. B., Bøtker, H. E. & Matchkov, V. V., Apr 2023, In: Cells. 12, 8, 21 p., 1108.

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Open Access

1 Citation (Scopus)

Hypoxia and ischemic stroke induce endothelial BKCa expression in cerebral arteries-a target for therapy?

Hinkley, V., Staehr, C., Matchkov, V., Rajanathan, R., Eiby, Y., Luque, N., Wright, I. J., Chand, K., Nguyen, H., Jones, N., Sandow, S. L. & Murphy, T., 11 Jun 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, S1, p. S84-S197

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Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke

Staehr, C., Giblin, J. T., Gutiérrez-Jiménez, E., Guldbrandsen, H. Ø., Tang, J., Sandow, S. L., Boas, D. A. & Matchkov, V., Jun 2023, In: Journal of the American Heart Association. 12, 11, e029527.

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Open Access

17 Citations (Scopus)

SorCS2 modulates neurovascular coupling via glutamatergic and calcium signaling in astrocytes

Staehr, C., Login, H., Postnov, D., Berenji Ardestani, S., Nolte, S. S., Beck, H. C., Nykjær, A. & Matchkov, V., 16 Feb 2023, bioRxiv.

Research output: Working paper/Preprint › Preprint

Open Access

The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension

Staehr, C., Aalkjær, C. & Matchkov, V., Oct 2023, In: Clinical Science. 137, 20, p. 1595–1618 24 p.

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Open Access

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11 Citations (Scopus)

11 Downloads (Pure)

2022

Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke

Staehr, C., Giblin, J. T., Gutiérrez-Jiménez, E., Guldbrandsen, H. Ø., Tang, J., Sandow, S. L., Boas, D. A. & Matchkov, V., 26 Aug 2022, bioRxiv.

Research output: Working paper/Preprint › Preprint

Open Access

Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function

Staehr, C., Rohde, P. D., Krarup, N. T., Ringgaard, S., Laustsen, C., Johnsen, J., Nielsen, R., Beck, H. C., Morth, J. P., Lykke-Hartmann, K., Jespersen, N. R., Abramochkin, D., Nyegaard, M., Bøtker, H. E., Aalkjaer, C. & Matchkov, V., Apr 2022, In: Journal of the American Heart Association. 11, 7, 47 p., e021814.

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Open Access

12 Citations (Scopus)

Stress adaptation in rats associate with reduced expression of cerebrovascular Kv7.4 channels and biphasic neurovascular responses

Staehr, C., Bouzinova, E., Wiborg, O. & Matchkov, V., 6 Jun 2022, In: Stress: The International Journal on the Biology of Stress . 25, 1, p. 227-234 8 p.

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Open Access

3 Citations (Scopus)

2021

Demand creates its own supply: The Na/K-ATPase controls metabolic reserve and flexibility

Staehr, C. & Matchkov, V., Jul 2021, In: Acta Physiologica. 232, 3, 2 p., e13673.

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Open Access

3 Citations (Scopus)

Does Src Kinase Mediated Vasoconstriction Impair Penumbral Reperfusion?

Guldbrandsen, H. Ø., Staehr, C., Iversen, N. K., Postnov, D. & Matchkov, V., 1 Jun 2021, In: Stroke. 52, 6, p. E250-E258 9 p.

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6 Citations (Scopus)

2020

Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine

Staehr, C., Rajanathan, R., Postnov, D., Hangaard, L., Bouzinova, E., Lykke-Hartmann, K., Bach, F. W., Sandow, S. L., Aalkjær, C. & Matchkov, V., 1 Oct 2020, In: Cardiovascular Research. 116, 12, p. 2009-2020 12 p., cvz306.

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19 Citations (Scopus)

PTPRG is an ischemia risk locus essential for HCO₃^--dependent regulation of endothelial function and tissue perfusion

Berg-Hansen, K., Staehr, C., Rohde, P. D., Homilius, C., Kim, S., Nyegaard, M., Matchkov, V. & Boedtkjer, E., Sept 2020, In: eLife. 9, p. 1-46 26 p., e57553.

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Open Access

15 Citations (Scopus)

2019

[Ca²⁺] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries—Relation to noradrenaline release and contraction

Hansen, T., Tarasova, O. S., Khammy, M. M., Ferreira, A., A. Kennard, J., Andresen, J., Staehr, C., L. Brain, K., Nilsson, H. & Aalkjær, C., Aug 2019, In: Acta Physiologica. 226, 4, 11 p., e13279.

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9 Citations (Scopus)

Abnormal neurovascular signaling in mouse model for familial hemiplegic migraine type 2

Matchkov, V., Staehr, C., Rajanathan, R., Postnov, D., Bouzinova, E. V., Lykke-Hartmann, K. & Aalkjær, C., 1 Apr 2019, In: The FASEB Journal. 33, p. 688.14 - 688.14

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An abundance of the Na,K-ATPase modulates homeostasis of blood glucose.

Matchkov, V. V., Duy, N. T., Rajanathan, R., Jeppesen, P. B., Bouzinova, E. & Staehr, C., 2019, p. 134-134. 1 p.

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Involvement of the Na ⁺ ,K ⁺-ATPase isoforms in control of cerebral perfusion

Staehr, C., Rajanathan, R. & Matchkov, V. V., 2019, In: Experimental Physiology. 104, 7, p. 1023-1028 6 p.

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11 Citations (Scopus)

Migraine-associated mutation in the a2 isoform Na,K-ATPase is associated with cardiomyopathy-like changes in the mouse heart

Bouzinova, E., Lykke-Hartmann, K., Nyengaard, J. R., Beck, H. C., Matchkov, V. & Staehr, C., 1 Nov 2019, In: Acta Physiologica (Print). 227, S721

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Smooth muscle Ca²⁺ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation

Staehr, C., Hangaard, L., Bouzinova, E. V., Kim, S., Rajanathan, R., Boegh Jessen, P., Luque, N., Xie, Z., Lykke-Hartmann, K., Sandow, S. L., Aalkjær, C. & Matchkov, V. V., Aug 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 8, p. 1570-1587 18 p., 0271678X18761712.

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Open Access

26 Citations (Scopus)

The Na,K-ATPase in vascular smooth muscle cells

Zhang, L., Staehr, C., Zeng, F., Bouzinova, E. V. & Matchkov, V. V., Jan 2019, Membrane transporters in the pathogenesis of cardiovascular and lung disorders. Orlov, S. N. (ed.). Cambridge, MA: Academic Press, p. 151-175 (Current Topics in Membranes, Vol. 83).

Research output: Contribution to book/anthology/report/proceeding › Review

11 Citations (Scopus)

Upregulation of Endothelial Kir2. 1 Channel Disturbs Neurovascular Coupling in Familial Hemiplegic Migraine

Staehr, C., Rajanathan, R. & Matchkov, V., 1 Nov 2019, In: Acta Physiologica (Print). 227, S721, p. 121-121 1 p.

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2018

Migraine associated mutation in the α2 isoform Na+,K+-ATPase leads to disturbance in neurovascular coupling

Staehr, C., Rajanathan, R., Bouzinova, E., Aalkjær, C., Bach, F. W. & Matchkov, V., 2018, In: Proc. Physiol. Soc.. 41, SA066

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The α2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc–dependent Ca2+ sensitization

Bouzinova, E., Hangaard, L., Staehr, C., Mazur, A., Chibalin, A. V., Sandow, S. L., Xie, Z., Aalkjær, C. & Matchkov, V., Sept 2018, In: Acta Physiologica. 223, 1, p. e13059 e13059.

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17 Citations (Scopus)

2017

Dysfunctional neurovascular coupling in familial hemiplegic migraine type 2

Staehr, C., Bouzinova, E., Lykke, K., Aalkjær, C. & Matchkov, V., 1 Feb 2017, In: Acta Physiologica (Print). 219, p. 8-9 2 p.

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Intravital investigation of rat mesenteric small artery tone and blood flow

Nyvad, J., Mazur, A., Postnov, D. D., Straarup, M. S., Soendergaard, A. M., Staehr, C., Brøndum, E., Aalkjaer, C. & Matchkov, V. V., 1 Aug 2017, In: The Journal of Physiology. 595, 15, p. 5037-5053 17 p.

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25 Citations (Scopus)

Na,K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase dependent connexin43 phosphorylation.

Hangaard, L., Bouzinova, E., Stæhr, C. A., Dam, V. S., Kim, S., Xie, Z., Aalkjær, C. & Matchkov, V., 7 Apr 2017, In: American Journal of Physiology: Cell Physiology. 4, 312, p. C385-C397 13 p.

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Open Access

21 Citations (Scopus)

2016

An associated with Familial Hemiplegic Migraine Type 2 mutation in the alpha-2 isoform Na,K-ATPase disturbs vascular responses in mouse brain

Staehr, C., Hangaard, L., Lykke-Hartmann, K., Bouzinova, E., Aalkjær, C. & Matchkov, V., 2016, In: Artery Research. 16, 1

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Dysfunctional neurovascular coupling in Familial hemiplegic migraine type 2

Staehr, C., Hangaard, L., Bouzinova, E., Lykke-Hartmann, K., Aalkjær, C. & Matchkov, V., 2016, In: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 23

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2015

Pro-contractile action of the Na,K-ATPase/Src-kinase signaling pathway in the vascular wall.

Bouzinova, E., Hangaard, L., Xie, Z., Staehr, C., Aalkjær, C. & Matchkov, V., 28 Aug 2015. 1 p.

Research output: Contribution to conference › Poster › Research › peer-review

The α2 Isoform of Na,K-ATPase Modulates Vascular Tone via Activation of Src kinase (Src) Signalling Pathway: a Lesion from Mouse Model for Familial Hemiplegic Migraine Type 2 (FHM2)

Matchkov, V., Hangaard, L., Staehr, C., Lykke-Hartmann, K., Xie, Z. & Aalkjær, C., 2015, In: The FASEB Journal. 29, 844.818

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α1-,α2-Na,K-ATPase and Kir 2.1 expression and their implications for cerebral artery function and migraine etiology in a mouse model of Familial Hemiplegic Migraine type 2

Sandow, S. L., Hinkley, V., Lykke-Hartmann, K., Hangaard, L., Staehr, C., Aalkjær, C. & Matchkov, V., 2015, In: Proceedings of the Australian Physiological Society. 46

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Open Access

Christian Stæhr

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