Christina C. Dahm

Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study

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  • Dominique S Michaud, Denmark
  • Valentina Gallo, Denmark
  • Brigitte Schlehofer, Denmark
  • Anne M Tjonneland, Denmark
  • Anja Olsen
  • Kim Overvad
  • Christina C Dahm
  • Rudolf Kaaks, Denmark
  • Annekatrin Lukanova, Denmark
  • Heiner Boeing, Denmark
  • Madlen Schutze, Denmark
  • Antonia Trichopoulou, Denmark
  • Christina Bamia, Denmark
  • Andreas Kyrozis, Denmark
  • Carlotta Sacerdote, Denmark
  • Claudia Agnoli, Denmark
  • Domenico Palli, Denmark
  • Rosario Tumino, Denmark
  • Amalia Mattiello, Denmark
  • Bas Bueno-de-Mesquita, Denmark
  • Martine Ros, Denmark
  • Petra H M Peeters, Denmark
  • Carla van Gils, Denmark
  • Eiliv Lund, Denmark
  • Kjersti Bakken, Denmark
  • Inger Gram, Denmark
  • Aurelio Barricarte, Denmark
  • Carmen Navarro, Denmark
  • Miren Dorronsoro, Denmark
  • Maria Sanchez Perez, Denmark
  • Laudina Rodriguez, Denmark
  • Eric Duell, Denmark
  • Goran Hallmans, Denmark
  • Beatrice Melin, Denmark
  • Jonas Manjer, Denmark
  • Signe Borgquist
  • Kay-Tee Khaw, Denmark
  • Nicholas J Wareham, Denmark
  • Naomi E Allen, Denmark
  • Konstantinos Tsilidis, Denmark
  • Isabelle Romieu, Denmark
  • Sabine Rinaldi, Denmark
  • Paolo Vineis, Denmark
  • Elio Riboli, Denmark
  • Institute of Epidemiology and Social Medicine
  • Klinisk Epidemiologisk Afdeling, Aalborg
BACKGROUND: The aetiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR = 1.62, 95% CI = 1.04-2.54) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR = 3.61, 95% CI = 1.75-7.46). CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, appears to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation.Impact: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.
Original languageEnglish
JournalCancer Epidemiology, Biomarkers & Prevention
Volume19
Issue10
Pages (from-to)2562-9
ISSN1055-9965
DOIs
Publication statusPublished - Oct 2010

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