Christina C. Dahm

Pre-diagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Veronika Fedirko
  • ,
  • Elio Riboli
  • ,
  • Anne Tjonneland
  • ,
  • Pietro Ferrari
  • ,
  • Anja Olsen
  • H Bas Bueno-de-Mesquita
  • ,
  • Franzel van Duijnhoven
  • ,
  • Teresa Norat
  • ,
  • Eugene Jansen
  • ,
  • Christina C Dahm
  • Kim Overvad
  • Marie-Christine Boutron-Ruault
  • ,
  • Francoise Clavel-Chapelon
  • ,
  • Antoine Racine
  • ,
  • Annekatrin Lukanova
  • ,
  • Birgit Teucher
  • ,
  • Heiner Boeing
  • ,
  • Krasimira Aleksandrova
  • ,
  • Antonia Trichopoulou
  • ,
  • Vassiliki Benetou
  • ,
  • Dimitrios Trichopoulos
  • ,
  • Sara Grioni
  • ,
  • Paolo Vineis
  • ,
  • Salvatore Panico
  • ,
  • Domenico Palli
  • ,
  • Rosario Tumino
  • ,
  • Peter D Siersema
  • ,
  • Petra H M Peeters
  • ,
  • Guri Skeie
  • ,
  • Magritt Brustad
  • ,
  • Maria-Dolores Chirlaque
  • ,
  • Aurelio Barricarte Gurrea
  • ,
  • Jose Ramón Quirós Garcia
  • ,
  • Maria-Jose Sanchez
  • ,
  • Miren Dorronsoro
  • ,
  • Catalina Bonet
  • ,
  • Richard Palmqvist
  • ,
  • Goran Hallmans
  • ,
  • Timothy J Key
  • ,
  • Francesca L Crowe
  • ,
  • Kay-Tee Khaw
  • ,
  • Nicholas J Wareham
  • ,
  • Isabelle I Romieu
  • ,
  • James McKay
  • ,
  • Petra A Wark
  • ,
  • Dora Romaguera
  • ,
  • Mazda Jenab
BACKGROUND: Individuals with higher blood 25-hydroxy-vitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D on mortality after CRC diagnosis is unknown. METHODS: The association between pre-diagnostic 25(OH)D levels and CRC-specific (N=444) and overall mortality (N=541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992-2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle and metabolic effect modifiers were also investigated.RESULTS: There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction in CRC-specific (Ptrend=0.04) and overall mortality (Ptrend=0.01). Participants with 25(OH)D levels in the highest quintile had an adjusted HR of 0.69 (95%CI: 0.50-0.93) for CRC-specific and 0.67 (95%CI: 0.50-0.88) for overall mortality, compared to the lowest quintile. Except for a possible interaction by pre-diagnostic dietary calcium intake (Pinteraction=0.01), no other potential modifying factors related to CRC survival were noted. The VDR (FokI and BsmI) and CASR (rs1801725) genotypes were not associated with survival.CONCLUSIONS: High pre-diagnostic 25(OH)D levels are associated with improved survival of patients with CRC. Impact: Our findings may stimulate further research directed at investigating the effects of blood vitamin D levels before, at, and after CRC diagnosis on outcomes in CRC patients.
Original languageEnglish
JournalCancer Epidemiology, Biomarkers & Prevention
Volume21
Issue4
Pages (from-to)582-93
ISSN1055-9965
DOIs
Publication statusPublished - Apr 2012

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