Christina C. Dahm

Plasma cotinine levels and pancreatic cancer in the EPIC cohort study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Max Leenders
  • ,
  • Shu-Chun Chuang
  • ,
  • Christina C Dahm
  • Kim Overvad
  • Per Magne Ueland
  • ,
  • Oivind Midttun
  • ,
  • Stein Emil Vollset
  • ,
  • Anne Tjønneland
  • ,
  • Jytte Halkjaer
  • ,
  • Mazda Jenab
  • ,
  • Françoise Clavel-Chapelon
  • ,
  • Marie-Christine Boutron-Ruault
  • ,
  • Rudolf Kaaks
  • ,
  • Federico Canzian
  • ,
  • Heiner Boeing
  • ,
  • Cornelia Weikert
  • ,
  • Antonia Trichopoulou
  • ,
  • Christina Bamia
  • ,
  • Androniki Naska
  • ,
  • Domenico Palli
  • ,
  • Valeria Pala
  • ,
  • Amalia Mattiello
  • ,
  • Rosario Tumino
  • ,
  • Carlotta Sacerdote
  • ,
  • Fränzel Jb van Duijnhoven
  • ,
  • Petra Hm Peeters
  • ,
  • Carla H van Gils
  • ,
  • Eiliv Lund
  • ,
  • Laudina Rodriguez
  • ,
  • Eric J Duell
  • ,
  • María-José Sánchez Pérez
  • ,
  • Esther Molina-Montes
  • ,
  • José María Huerta Castaño
  • ,
  • Aurelio Barricarte
  • ,
  • Nerea Larrañaga
  • ,
  • Dorthe Johansen
  • ,
  • Björn Lindkvist
  • ,
  • Malin Sund
  • ,
  • Weimin Ye
  • ,
  • Kay-Tee Khaw
  • ,
  • Nicholas J Wareham
  • ,
  • Dominique S Michaud
  • ,
  • Elio Riboli
  • ,
  • Wei W Xun
  • ,
  • Naomi E Allen
  • ,
  • Francesca L Crowe
  • ,
  • H Bas Bueno-de-Mesquita
  • ,
  • Paolo Vineis
Smoking is an established risk factor for pancreatic cancer, previously investigated by the means of questionnaires. Using cotinine as a biomarker for tobacco exposure allows more accurate quantitative analyses to be performed. This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. Using liquid chromatography-mass spectrometry, plasma cotinine levels were analyzed on average 8.0 years before cancer onset (5-95% range: 2.8-12.0 years). The relation between plasma cotinine levels and pancreatic cancer was analyzed with conditional logistic regression for different levels of cotinine in a population of never and current smokers. This was also done for the self-reported number of smoked cigarettes per day at baseline. Every increase of 350 nmol/L of plasma cotinine was found to significantly elevate risk of pancreatic cancer (odds ratio (OR): 1.33, 95% confidence interval (CI): 1.11-1.60). People with a cotinine level over 1187.8 nmol/L, a level comparable to smoking 17 cigarettes per day, have an elevated risk of pancreatic cancer, compared to people with cotinine levels below 55 nmol/L (OR: 3.66, 95% CI: 1.44-9.26). The results for self-reported smoking at baseline also show an increased risk of pancreatic cancer from cigarette smoking based on questionnaire information. People who smoke more than 30 cigarettes per day showed the highest risk compared to never smokers (OR: 4.15, 95% CI: 1.02-16.42). This study is the first to show that plasma cotinine levels are strongly related to pancreatic cancer. © 2011 Wiley-Liss, Inc.
Original languageEnglish
JournalInternational Journal of Cancer
Volume131
Issue4
Pages (from-to)997-1002
ISSN0020-7136
DOIs
Publication statusPublished - 15 Aug 2012

See relations at Aarhus University Citationformats

ID: 40408727