Christina C. Dahm

Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Physical activity, mediating factors and risk of colon cancer : insights into adiposity and circulating biomarkers from the EPIC cohort. / Aleksandrova, Krasimira; Jenab, Mazda; Leitzmann, Michael; Bueno-de-Mesquita, Bas; Kaaks, Rudolf; Trichopoulou, Antonia; Bamia, Christina; Lagiou, Pagona; Rinaldi, Sabina; Freisling, Heinz; Carayol, Marion; Pischon, Tobias; Drogan, Dagmar; Weiderpass, Elisabete; Jakszyn, Paula; Overvad, Kim; Dahm, Christina C; Tjønneland, Anne; Bouton-Ruault, Marie-Christine; Kühn, Tilman; Peppa, Eleni; Valanou, Elissavet; La Vecchia, Carlo; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Agnoli, Claudia; Tumino, Rosario; May, Anne; van Vulpen, Jonna; Benjaminsen Borch, Kristin; Oluwafemi Oyeyemi, Sunday; Quirós, J Ramón; Bonet, Catalina; Sánchez, María-José; Dorronsoro, Miren; Navarro, Carmen; Barricarte, Aurelio; van Guelpen, Bethany; Wennberg, Patrik; Key, Timothy J; Khaw, Kay-Tee; Wareham, Nicholas; Assi, Nada; Ward, Heather A; Aune, Dagfinn; Riboli, Elio; Boeing, Heiner.

In: International Journal of Epidemiology, Vol. 46, No. 6, 01.12.2017, p. 1823-1835.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Aleksandrova, K, Jenab, M, Leitzmann, M, Bueno-de-Mesquita, B, Kaaks, R, Trichopoulou, A, Bamia, C, Lagiou, P, Rinaldi, S, Freisling, H, Carayol, M, Pischon, T, Drogan, D, Weiderpass, E, Jakszyn, P, Overvad, K, Dahm, CC, Tjønneland, A, Bouton-Ruault, M-C, Kühn, T, Peppa, E, Valanou, E, La Vecchia, C, Palli, D, Panico, S, Sacerdote, C, Agnoli, C, Tumino, R, May, A, van Vulpen, J, Benjaminsen Borch, K, Oluwafemi Oyeyemi, S, Quirós, JR, Bonet, C, Sánchez, M-J, Dorronsoro, M, Navarro, C, Barricarte, A, van Guelpen, B, Wennberg, P, Key, TJ, Khaw, K-T, Wareham, N, Assi, N, Ward, HA, Aune, D, Riboli, E & Boeing, H 2017, 'Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort', International Journal of Epidemiology, vol. 46, no. 6, pp. 1823-1835. https://doi.org/10.1093/ije/dyx174

APA

Aleksandrova, K., Jenab, M., Leitzmann, M., Bueno-de-Mesquita, B., Kaaks, R., Trichopoulou, A., Bamia, C., Lagiou, P., Rinaldi, S., Freisling, H., Carayol, M., Pischon, T., Drogan, D., Weiderpass, E., Jakszyn, P., Overvad, K., Dahm, C. C., Tjønneland, A., Bouton-Ruault, M-C., ... Boeing, H. (2017). Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort. International Journal of Epidemiology, 46(6), 1823-1835. https://doi.org/10.1093/ije/dyx174

CBE

Aleksandrova K, Jenab M, Leitzmann M, Bueno-de-Mesquita B, Kaaks R, Trichopoulou A, Bamia C, Lagiou P, Rinaldi S, Freisling H, Carayol M, Pischon T, Drogan D, Weiderpass E, Jakszyn P, Overvad K, Dahm CC, Tjønneland A, Bouton-Ruault M-C, Kühn T, Peppa E, Valanou E, La Vecchia C, Palli D, Panico S, Sacerdote C, Agnoli C, Tumino R, May A, van Vulpen J, Benjaminsen Borch K, Oluwafemi Oyeyemi S, Quirós JR, Bonet C, Sánchez M-J, Dorronsoro M, Navarro C, Barricarte A, van Guelpen B, Wennberg P, Key TJ, Khaw K-T, Wareham N, Assi N, Ward HA, Aune D, Riboli E, Boeing H. 2017. Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort. International Journal of Epidemiology. 46(6):1823-1835. https://doi.org/10.1093/ije/dyx174

MLA

Vancouver

Aleksandrova K, Jenab M, Leitzmann M, Bueno-de-Mesquita B, Kaaks R, Trichopoulou A et al. Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort. International Journal of Epidemiology. 2017 Dec 1;46(6):1823-1835. https://doi.org/10.1093/ije/dyx174

Author

Aleksandrova, Krasimira ; Jenab, Mazda ; Leitzmann, Michael ; Bueno-de-Mesquita, Bas ; Kaaks, Rudolf ; Trichopoulou, Antonia ; Bamia, Christina ; Lagiou, Pagona ; Rinaldi, Sabina ; Freisling, Heinz ; Carayol, Marion ; Pischon, Tobias ; Drogan, Dagmar ; Weiderpass, Elisabete ; Jakszyn, Paula ; Overvad, Kim ; Dahm, Christina C ; Tjønneland, Anne ; Bouton-Ruault, Marie-Christine ; Kühn, Tilman ; Peppa, Eleni ; Valanou, Elissavet ; La Vecchia, Carlo ; Palli, Domenico ; Panico, Salvatore ; Sacerdote, Carlotta ; Agnoli, Claudia ; Tumino, Rosario ; May, Anne ; van Vulpen, Jonna ; Benjaminsen Borch, Kristin ; Oluwafemi Oyeyemi, Sunday ; Quirós, J Ramón ; Bonet, Catalina ; Sánchez, María-José ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte, Aurelio ; van Guelpen, Bethany ; Wennberg, Patrik ; Key, Timothy J ; Khaw, Kay-Tee ; Wareham, Nicholas ; Assi, Nada ; Ward, Heather A ; Aune, Dagfinn ; Riboli, Elio ; Boeing, Heiner. / Physical activity, mediating factors and risk of colon cancer : insights into adiposity and circulating biomarkers from the EPIC cohort. In: International Journal of Epidemiology. 2017 ; Vol. 46, No. 6. pp. 1823-1835.

Bibtex

@article{39d41eb978b945fd9f6bf4f644f82de4,
title = "Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort",
abstract = "Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer.Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline.Results: High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs <91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively.Conclusions: Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.",
keywords = "Journal Article, physical activity, adiposity, biomarkers, colon cancer, mediating factors",
author = "Krasimira Aleksandrova and Mazda Jenab and Michael Leitzmann and Bas Bueno-de-Mesquita and Rudolf Kaaks and Antonia Trichopoulou and Christina Bamia and Pagona Lagiou and Sabina Rinaldi and Heinz Freisling and Marion Carayol and Tobias Pischon and Dagmar Drogan and Elisabete Weiderpass and Paula Jakszyn and Kim Overvad and Dahm, {Christina C} and Anne Tj{\o}nneland and Marie-Christine Bouton-Ruault and Tilman K{\"u}hn and Eleni Peppa and Elissavet Valanou and {La Vecchia}, Carlo and Domenico Palli and Salvatore Panico and Carlotta Sacerdote and Claudia Agnoli and Rosario Tumino and Anne May and {van Vulpen}, Jonna and {Benjaminsen Borch}, Kristin and {Oluwafemi Oyeyemi}, Sunday and Quir{\'o}s, {J Ram{\'o}n} and Catalina Bonet and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Miren Dorronsoro and Carmen Navarro and Aurelio Barricarte and {van Guelpen}, Bethany and Patrik Wennberg and Key, {Timothy J} and Kay-Tee Khaw and Nicholas Wareham and Nada Assi and Ward, {Heather A} and Dagfinn Aune and Elio Riboli and Heiner Boeing",
year = "2017",
month = dec,
day = "1",
doi = "10.1093/ije/dyx174",
language = "English",
volume = "46",
pages = "1823--1835",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Physical activity, mediating factors and risk of colon cancer

T2 - insights into adiposity and circulating biomarkers from the EPIC cohort

AU - Aleksandrova, Krasimira

AU - Jenab, Mazda

AU - Leitzmann, Michael

AU - Bueno-de-Mesquita, Bas

AU - Kaaks, Rudolf

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Lagiou, Pagona

AU - Rinaldi, Sabina

AU - Freisling, Heinz

AU - Carayol, Marion

AU - Pischon, Tobias

AU - Drogan, Dagmar

AU - Weiderpass, Elisabete

AU - Jakszyn, Paula

AU - Overvad, Kim

AU - Dahm, Christina C

AU - Tjønneland, Anne

AU - Bouton-Ruault, Marie-Christine

AU - Kühn, Tilman

AU - Peppa, Eleni

AU - Valanou, Elissavet

AU - La Vecchia, Carlo

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - May, Anne

AU - van Vulpen, Jonna

AU - Benjaminsen Borch, Kristin

AU - Oluwafemi Oyeyemi, Sunday

AU - Quirós, J Ramón

AU - Bonet, Catalina

AU - Sánchez, María-José

AU - Dorronsoro, Miren

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - van Guelpen, Bethany

AU - Wennberg, Patrik

AU - Key, Timothy J

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas

AU - Assi, Nada

AU - Ward, Heather A

AU - Aune, Dagfinn

AU - Riboli, Elio

AU - Boeing, Heiner

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer.Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline.Results: High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs <91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively.Conclusions: Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.

AB - Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer.Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline.Results: High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs <91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively.Conclusions: Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.

KW - Journal Article

KW - physical activity

KW - adiposity

KW - biomarkers

KW - colon cancer

KW - mediating factors

U2 - 10.1093/ije/dyx174

DO - 10.1093/ije/dyx174

M3 - Journal article

C2 - 29025032

VL - 46

SP - 1823

EP - 1835

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 6

ER -