Christina C. Dahm

Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Aurelie Moskal, Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
  • ,
  • Pedro T Pisa, Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France., Denmark
  • Pietro Ferrari, Nutritional Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
  • ,
  • Graham Byrnes, Biostatistics Group, International Agency for Research on Cancer, Lyon, France.
  • ,
  • Heinz Freisling, Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
  • ,
  • Marie-Christine Boutron-Ruault, Center for research in Epidemiology and Population Health, Nutrition, Hormones and Women's Health, INSERM U1018, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France; Institut Gustave-Roussy, Villejuif, France.
  • ,
  • Claire Cadeau, Center for research in Epidemiology and Population Health, Nutrition, Hormones and Women's Health, INSERM U1018, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France; Institut Gustave-Roussy, Villejuif, France.
  • ,
  • Laura Nailler, Center for research in Epidemiology and Population Health, Nutrition, Hormones and Women's Health, INSERM U1018, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France; Institut Gustave-Roussy, Villejuif, France.
  • ,
  • Andrea Wendt, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Denmark
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • ,
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany.
  • ,
  • Brian Buijsse, Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany.
  • ,
  • Anne Tjønneland, Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark.
  • ,
  • Jytte Halkjær, Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark.
  • ,
  • Christina Catherine Dahm
  • Stephanie E Chiuve, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.
  • ,
  • Jose R Quirós, Public Health and Health Planning Directorate, Asturias, Spain.
  • ,
  • Genevieve Buckland, Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain.
  • ,
  • Esther Molina-Montes, Andalusian School of Public Health, Granada, Spain.
  • ,
  • Pilar Amiano, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BIODonostia Research Institute, San Sebastian, Spain.
  • ,
  • José M Huerta Castaño, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain.
  • ,
  • Aurelio Barricarte Gurrea, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Navarre Public Health Institute, Pamplona, Spain.
  • ,
  • Kay-Tee Khaw, University of Cambridge
  • ,
  • Marleen A Lentjes, University of Cambridge
  • ,
  • Timothy J Key, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
  • ,
  • Dora Romaguera, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain.
  • ,
  • Anne-Claire Vergnaud, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • ,
  • Antonia Trichopoulou, WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; Hellenic Health Foundation, Athens, Greece.
  • ,
  • Christina Bamia, WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; Hellenic Health Foundation, Athens, Greece.
  • ,
  • Philippos Orfanos, WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; Hellenic Health Foundation, Athens, Greece.
  • ,
  • Domenico Palli, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.
  • ,
  • Valeria Pala, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • ,
  • Rosario Tumino, Cancer Registry and Histopathology Unit, "Civile - M.P. Arezzo" Hospital, Ragusa, Italy.
  • ,
  • Carlotta Sacerdote, HuGeF Foundation and Center for Cancer Prevention CPO-Piemonte, Torino, Italy.
  • ,
  • Maria Santucci de Magistris, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy., Denmark
  • H Bas Bueno-de-Mesquita, The National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands.
  • ,
  • Marga C Ocké, The National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
  • ,
  • Joline W J Beulens, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
  • ,
  • Ulrika Ericson, Lund University
  • ,
  • Isabel Drake, Lund University
  • ,
  • Lena M Nilsson, Department of Public Health and Clinical Medicine, Nutrition Research, Umeå University, Umeå, Sweden.
  • ,
  • Anna Winkvist, University of Gothenburg
  • ,
  • Elisabete Weiderpass, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Research, Cancer Registry of Norway, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Samfundet Folkhälsan, Helsinki, Finland.
  • ,
  • Anette Hjartåker, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • ,
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • ,
  • Nadia Slimani, Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.

BACKGROUND: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses.

METHODOLOGY/PRINCIPAL FINDINGS: We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores.

CONCLUSION/SIGNIFICANCE: The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and perspectives of using nutrient patterns in future studies particularly at international level.

Original languageEnglish
JournalPLOS ONE
Volume9
Issue6
Pages (from-to)e98647
ISSN1932-6203
DOIs
Publication statusPublished - 2014

See relations at Aarhus University Citationformats

ID: 77430438