Christina C. Dahm

Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Joseph A Rothwell, France. Electronic address: joseph.rothwell@inserm.fr., INSERM, France
  • Neil Murphy, IARC, France
  • Jelena Bešević, Imperial College London, United Kingdom
  • Nathalie Kliemann, 5LPO-BirdLife France, France
  • ,
  • Mazda Jenab, IARC, France
  • Pietro Ferrari, IARC, France
  • David Achaintre, IARC, France
  • Audrey Gicquiau, IARC, France
  • Béatrice Vozar, IARC, France
  • Augustin Scalbert, IARC, France
  • Inge Huybrechts, IARC, France
  • Heinz Freisling, IARC, France
  • Cornelia Prehn, Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany
  • Jerzy Adamski, Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany
  • Amanda J Cross, Imperial College London, United Kingdom
  • Valeria Maria Pala, Imperial College London, United Kingdom
  • Marie-Christine Boutron-Ruault, Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France., France
  • Christina C Dahm
  • Kim Overvad
  • Inger Torhild Gram, University of Tromsø, Tromsø, Norway
  • Torkjel M Sandanger, University of Tromsø, Tromsø, Norway
  • Guri Skeie, University of Tromsø, Tromsø, Norway
  • Paula Jakszyn, Ramon Llull University, Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain., Spain
  • Kostas K Tsilidis, University of Ioannina School of Medicine, Imperial College London, Greece
  • Krasimira Aleksandrova, Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany., Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany., Germany
  • Matthias B Schulze, Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany., Germany
  • David J Hughes, University College Dublin, Dublin, Ireland
  • Bethany van Guelpen, Department of Radiation Sciences, Oncology Unit, Umea University, Sweden
  • Stina Bodén, Department of Radiation Sciences, Oncology Unit, Umea University, Sweden
  • Maria-José Sánchez, Escuela Andaluza de Salud Pública (EASP), Granada, Spain
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., United Kingdom
  • Verena Katzke, Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts, Heidelberg, Germany
  • Tilman Kühn, Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts, Heidelberg, Germany
  • Sandra Colorado-Yohar, University of Antioquia, CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Spain
  • Rosario Tumino, Cancer Registry and Histopathology Department , Provincial Health Authority (ASP), Ragusa, Italy., Italy
  • Bas Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM), Netherlands
  • Paolo Vineis, Imperial College London, Italian Institute of Technology, Genova, United Kingdom
  • Giovanna Masala, Institute for Cancer Research, Italy
  • Salvatore Panico, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy., Italy
  • Anne Kirstine Eriksen, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Denmark
  • Anne Tjønneland, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Denmark
  • Dagfinn Aune, Imperial College London, Bjørknes University College, Oslo University Hospital, United Kingdom
  • Elisabete Weiderpass, IARC, France
  • Gianluca Severi, Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France., France
  • Véronique Chajès, IARC, France
  • Marc J Gunter, International Agency for Research on Cancer, 69008 Lyon, France.

BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer (EPIC) cohort.

METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5,738 cancer-free EPIC participants with metabolomics data. Partial least squares regression was used to derive fatty acid and endogenous metabolite signatures of WCRF/AICR score in this group. In an independent set of 1,608 colorectal cancer cases and matched controls, odds ratios (OR) and 95% confidence intervals (CI) were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.

RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of elevated odd-chain fatty acids, serine, glycine and specific phosphatidylcholines. Signatures were more strongly inversely associated with colorectal cancer risk (fatty acids: OR 0.51 per unit increase, 95% CI 0.29-0.90; endogenous metabolites: OR 0.62 per unit change, 95% CI 0.50-0.78) than the WCRF/AICR score (OR 0.93 per unit change, 95% CI 0.86-1.00) overall. Signature associations were stronger in male compared to female participants.

CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.

Original languageEnglish
JournalClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
ISSN1542-3565
DOIs
Publication statusE-pub ahead of print - 3 Dec 2020

    Research areas

  • colorectal neoplasm, World Cancer Research Fund/American Institute for Cancer Research recommendations, risk factors, targeted metabolomics

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