Christina C. Dahm

Interactions of mitochondrial thiols with nitric oxide

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Nikola J Costa, Denmark
  • Christina C Dahm
  • Fiona Hurrell, Denmark
  • Ellen R Taylor, Denmark
  • Michael P Murphy, Denmark
The interaction of nitric oxide (NO) with mitochondria is of pathological significance and is also a potential mechanism for the regulation of mitochondrial function. Some of the ways in which NO may affect mitochondria are by reacting with low-molecular-weight thiols such as glutathione and with protein thiols. However, the detailed mechanisms and the consequences of these interactions for mitochondria are uncertain. Here we review mitochondrial thiol metabolism, outline how NO and its metabolites interact with thiols, and discuss the implications of these reactions for mitochondrial and cell function.
Original languageEnglish
JournalAntioxidants & Redox Signaling
Volume5
Issue3
Pages (from-to)291-305
Number of pages14
ISSN1523-0864
DOIs
Publication statusPublished - 2003
Externally publishedYes

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