Christina C. Dahm

Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • A J Cooper
  • ,
  • N G Forouhi
  • ,
  • Z Ye
  • ,
  • B Buijsse
  • ,
  • L Arriola
  • ,
  • B Balkau
  • ,
  • A Barricarte
  • ,
  • J W J Beulens
  • ,
  • H Boeing
  • ,
  • F L Büchner
  • ,
  • C C Dahm
  • B de Lauzon-Guillain
  • ,
  • G Fagherazzi
  • ,
  • P W Franks
  • ,
  • C Gonzalez
  • ,
  • S Grioni
  • ,
  • R Kaaks
  • ,
  • T J Key
  • ,
  • G Masala
  • ,
  • C Navarro
  • ,
  • P Nilsson
  • ,
  • K Overvad
  • S Panico
  • ,
  • J Ramón Quirós
  • ,
  • O Rolandsson
  • ,
  • Nina Roswall, Medicinsk Sociologi, Denmark
  • C Sacerdote
  • ,
  • M-J Sánchez
  • ,
  • N Slimani
  • ,
  • I Sluijs
  • ,
  • A M W Spijkerman
  • ,
  • B Teucher
  • ,
  • A Tjonneland
  • ,
  • R Tumino
  • ,
  • S J Sharp
  • ,
  • C Langenberg
  • ,
  • E J M Feskens
  • ,
  • E Riboli
  • ,
  • N J Wareham
  • ,
  • The InterAct Consortium
Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.European Journal of Clinical Nutrition advance online publication, 1 August 2012; doi:10.1038/ejcn.2012.85.
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue10
Pages (from-to)1082-1092
Number of pages11
ISSN0954-3007
DOIs
Publication statusPublished - Oct 2012

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