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Christina C. Dahm

Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study

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  • Mauro Serafini
  • ,
  • Paula Jakszyn
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  • Leila Luján-Barroso
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  • Antonio Agudo
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  • H Bas Bueno-de-Mesquita
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  • Fränzel J B van Duijnhoven
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  • Mazda Jenab
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  • Carmen Navarro
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  • Domenico Palli
  • ,
  • Heiner Boeing
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  • Peter Wallström
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  • Sara Regnér
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  • Mattijs E Numans
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  • Fatima Carneiro
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  • Marie-Christine Boutron-Ruault
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  • Françoise Clavel-Chapelon
  • ,
  • Sophie Morois
  • ,
  • Sara Grioni
  • ,
  • Salvatore Panico
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  • Rosario Tumino
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  • Carlotta Sacerdote
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  • José Ramon Quirós
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  • Esther Molina-Montes
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  • Jose M Huerta Castaño
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  • Aurelio Barricarte
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  • Pilar Amiano
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  • Kay-Tee Khaw
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  • Nicholas Wareham
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  • Naomi E Allen
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  • Timothy J Key
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  • Suzanne M Jeurnink
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  • Petra Hm Peeters
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  • Christina Bamia
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  • Elisabeth Valanou
  • ,
  • Antonia Trichopoulou
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  • Rudolf Kaaks
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  • Annekatrin Lukanova
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  • Manuela M Bergmann
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  • Björn Lindkvist
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  • Roger Stenling
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  • Ingegerd Johansson
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  • Christina C Dahm
  • Kim Overvad
  • Majken Jensen
  • ,
  • Anja Olsen
  • Anne Tjonneland
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  • Eiliv Lund
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  • Sabina Rinaldi
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  • Dominique Michaud
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  • Traci Mouw
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  • Elio Riboli
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  • Carlos A González
A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary Total Antioxidant Capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric Reducing Antioxidant Potential, (FRAP) and Total Radical-Trapping Antioxidant Parameter, (TRAP), measuring reducing and chain breaking antioxidant capacity, were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and non cardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the 5(th) quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend
Original languageEnglish
JournalInternational Journal of Cancer
Volume131
Issue4
Pages (from-to)E544-54
Number of pages11
ISSN0020-7136
DOIs
Publication statusPublished - 2012

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