Christina C. Dahm

Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Antoine Racine, France
  • Franck Carbonnel, France
  • Simon S M Chan, United Kingdom
  • Andrew R Hart, United Kingdom
  • H Bas Bueno-de-Mesquita, Netherlands
  • Bas Oldenburg, Netherlands
  • Fiona D M van Schaik, Netherlands
  • Anne Tjønneland, Denmark
  • Anja Olsen
  • Christina C Dahm
  • Timothy Key, United Kingdom
  • Robert Luben, United Kingdom
  • Kay-Tee Khaw, United Kingdom
  • Elio Riboli, United Kingdom
  • Olof Grip, Sweden
  • Stefan Lindgren, Sweden
  • Göran Hallmans, Sweden
  • Pontus Karling, Sweden
  • Françoise Clavel-Chapelon, France
  • Manuela M Bergman, Germany
  • Heiner Boeing
  • ,
  • Rudolf Kaaks, Germany
  • Verena A Katzke
  • ,
  • Domenico Palli, Italy
  • G Masala, Italy
  • Prevost Jantchou, France
  • Marie-Christine Boutron-Ruault, France

BACKGROUND: Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks.

METHODS: Within the prospective EPIC (European Prospective Investigation into Cancer) study, we set up a nested matched case-control study among 366,351 participants with inflammatory bowel disease data, including 256 incident cases of UC and 117 of CD, and 4 matched controls per case. Dietary intake was recorded at baseline from validated food frequency questionnaires. Incidence rate ratios of developing UC and CD were calculated for quintiles of the Mediterranean diet score and a posteriori dietary patterns produced by factor analysis.

RESULTS: No dietary pattern was associated with either UC or CD risks. However, when excluding cases occurring within the first 2 years after dietary assessment, there was a positive association between a "high sugar and soft drinks" pattern and UC risk (incidence rate ratios for the fifth versus first quintile, 1.68 [1.00-2.82]; Ptrend = 0.02). When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.

CONCLUSIONS: A diet imbalance with high consumption of sugar and soft drinks and low consumption of vegetables was associated with UC risk. Further studies are needed to investigate whether microbiota alterations or other mechanisms mediate this association.

Original languageEnglish
JournalInflammatory Bowel Diseases
Volume22
Issue2
Pages (from-to)345-354
Number of pages10
ISSN1078-0998
DOIs
Publication statusPublished - Feb 2016

    Research areas

  • environmental factors, nutrition, dietary pattern, IBD

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