Christina C. Dahm

Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

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  • Konstantinos K Tsilidis, Cancer Epidemiology Unit, University of Oxford, Oxford, UK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., United Kingdom
  • Naomi E Allen, United Kingdom
  • Paul N Appleby, United Kingdom
  • Sabine Rohrmann, Switzerland
  • Ute Nöthlings, Germany
  • Larraitz Arriola, Spain
  • Marc J Gunter, United Kingdom
  • Veronique Chajes, France
  • Sabina Rinaldi
  • ,
  • Isabelle Romieu, France
  • Neil Murphy, United Kingdom
  • Elio Riboli, United Kingdom
  • Ioanna Tzoulaki, Greece
  • Rudolf Kaaks, Germany
  • Annekatrin Lukanova, Germany
  • Heiner Boeing, Germany
  • Tobias Pischon, Germany
  • Christina C Dahm
  • Kim Overvad
  • J Ramón Quirós, Spain
  • Ana Fonseca-Nunes, Spain
  • Esther Molina-Montes, Spain
  • Diana Gavrila Chervase, Spain
  • Eva Ardanaz, Spain
  • Kay T Khaw, United Kingdom
  • Nick J Wareham, United Kingdom
  • Nina Roswall, Denmark
  • Anne Tjønneland, Denmark
  • Pagona Lagiou, Greece
  • Dimitrios Trichopoulos, United States
  • Antonia Trichopoulou, Greece
  • Domenico Palli, Italy
  • Valeria Pala, Italy
  • Rosario Tumino, Italy
  • Paolo Vineis, United Kingdom
  • H Bas Bueno-de-Mesquita, United Kingdom
  • Johan Malm, Sweden
  • Marju Orho-Melander, Sweden
  • Mattias Johansson, France
  • Pär Stattin, Sweden
  • Ruth C Travis, United Kingdom
  • Timothy J Key, United Kingdom

The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC). Among 139,131 eligible men, 4,531 were diagnosed with prostate cancer over an average follow-up of 12 years. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by EPIC-participating center and age at recruitment, and adjusted for education, smoking status, body mass index, waist circumference, and physical activity. In a subset of men without prostate cancer, the cross-sectional association between circulating concentrations of androgens and insulin-like growth factor proteins with diabetes status was also investigated using linear regression models. Compared to men with no diabetes, men with diabetes had a 26% lower risk of prostate cancer (HR, 0.74; 95% CI, 0.63 - 0.86). There was no evidence that the association differed by stage (P-heterogeneity, 0.19) or grade (P-heterogeneity, 0.48) of the disease, although the numbers were small in some disease subgroups. In a subset of 626 men with hormone measurements, circulating concentrations of androstenedione, total testosterone and insulin-like growth factor binding protein-three were lower in men with diabetes compared to men without diabetes. This large European study has confirmed an inverse association between self-reported diabetes mellitus and subsequent risk of prostate cancer. © 2014 Wiley Periodicals, Inc.

Original languageEnglish
JournalInternational Journal of Cancer
Volume136
Issue2
Pages (from-to)372-81
Number of pages10
ISSN0020-7136
DOIs
Publication statusPublished - 15 Jan 2015

    Research areas

  • type 2 diabetes, prostate cancer, cohort study, androgens, insulin-like growth factor proteins

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