Christina C. Dahm

Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

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  • Dominique S Michaud, Denmark
  • Valentina Gallo, Denmark
  • Brigitte Schlehofer, Denmark
  • Anne Tjønneland, Denmark
  • Anja Olsen
  • Kim Overvad
  • Christina C Dahm
  • Birgit Teucher, Denmark
  • Annekatrin Lukanova, Denmark
  • Heiner Boeing, Denmark
  • Madlen Schütze, Denmark
  • Antonia Trichopoulou, Denmark
  • Pagona Lagiou, Denmark
  • Andreas Kyrozis, Denmark
  • Carlotta Sacerdote, Denmark
  • Vittorio Krogh, Denmark
  • Giovanna Masala, Denmark
  • Rosario Tumino, Denmark
  • Amalia Mattiello, Denmark
  • H Bas Bueno-de-Mesquita, Denmark
  • Martine M Ros, Denmark
  • Petra Hm Peeters, Denmark
  • Carla H van Gils, Denmark
  • Guri Skeie, Denmark
  • Dagrun Engeset, Denmark
  • Christine L Parr, Denmark
  • Eva Ardanaz, Denmark
  • Maria-Dolores Chirlaque, Denmark
  • Miren Dorronsoro, Denmark
  • Maria José Sánchez, Denmark
  • Marcial Argüelles, Denmark
  • Paula Jakszyn, Denmark
  • Lena M Nilsson, Denmark
  • Beatrice S Melin, Denmark
  • Jonas Manjer, Denmark
  • Elisabet Wirfält, Denmark
  • Kay-Tee Khaw, Denmark
  • Nick Wareham, Denmark
  • Naomi E Allen, Denmark
  • Timothy J Key, Denmark
  • Isabelle Romieu, Denmark
  • Paolo Vineis, Denmark
  • Elio Riboli, Denmark
  • Institute of Epidemiology and Social Medicine
  • Klinisk Epidemiologisk Afdeling, Aalborg
BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). DESIGN: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors. RESULTS: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming ≥100 mL coffee and tea per day compared with those consuming <100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant. CONCLUSIONS: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.
Original languageEnglish
JournalAmerican Journal of Clinical Nutrition
Pages (from-to)1145-1150
Publication statusPublished - 2010

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