Christina C. Dahm

Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • J Y Park, Denmark
  • C C Dahm
  • R H Keogh, Denmark
  • P N Mitrou, Denmark
  • B J Cairns, Denmark
  • D C Greenwood, Denmark
  • E A Spencer, Denmark
  • I S Fentiman, Denmark
  • M J Shipley, Denmark
  • E J Brunner, Denmark
  • J E Cade, Denmark
  • V J Burley, Denmark
  • G D Mishra, Denmark
  • D Kuh, Denmark
  • A M Stephen, Denmark
  • I R White, Denmark
  • R N Luben, Denmark
  • A A Mulligan, Denmark
  • K-T Khaw, Denmark
  • S A Rodwell, Denmark
  • Institute of Epidemiology and Social Medicine
Background:Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.Methods:We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).Results:Compared with individuals in the lightest category of drinkers (>0-<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5-<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15-<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30-<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with >/=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.Conclusion:We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.British Journal of Cancer advance online publication, 20 July 2010; doi:10.1038/sj.bjc.6605802 www.bjcancer.com.
Original languageEnglish
JournalBritish Journal of Cancer
Volume103
Issue5
Pages (from-to)747-56
ISSN0007-0920
DOIs
Publication statusPublished - 2010

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