Christina C. Dahm

Abdominal Obesity, Weight Gain during Adulthood and Risk of Liver and Biliary Tract Cancer in a European Cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Sabrina Schlesinger
  • ,
  • Krasimira Aleksandrova
  • ,
  • Tobias Pischon
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  • Veronika Fedirko
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  • Mazda Jenab
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  • Elisabeth Trepo
  • ,
  • Paolo Boffetta
  • ,
  • Christina C Dahm
  • Kim Overvad
  • Anne Tjønneland
  • ,
  • Jytte Halkjaer
  • ,
  • Guy Fagherazzi
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  • Marie-Christine Boutron-Ruault
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  • Franck Carbonnel
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  • Rudolf Kaaks
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  • Annekatrin Lukanova
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  • Heiner Boeing
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  • Antonia Trichopoulou
  • ,
  • Christina Bamia
  • ,
  • Pagona Lagiou
  • ,
  • Domenico Palli
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  • Sara Grioni
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  • Salvatore Panico
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  • Rosario Tumino
  • ,
  • Paolo Vineis
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  • H Bas Bueno-de-Mesquita
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  • Saskia van den Berg
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  • Petra H M Peeters
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  • Tonje Braaten
  • ,
  • Elisabete Weiderpass
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  • J Ramón Quirós
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  • Noémie Travier
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  • María-José Sánchez
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  • Carmen Navarro
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  • Aurelio Barricarte
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  • Miren Dorronsoro
  • ,
  • Björn Lindkvist
  • ,
  • Sara Regner
  • ,
  • Mårten Werner
  • ,
  • Malin Sund
  • ,
  • Kay-Tee Khaw
  • ,
  • Nicholas Wareham
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  • Ruth C Travis
  • ,
  • Teresa Norat
  • ,
  • Petra A Wark
  • ,
  • Elio Riboli
  • ,
  • Ute Nöthlings
General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intra- (IBDC) and extrahepatic bile duct system cancer (EBDSC including gallbladder cancer (GBC)) among 359,525 men and women in the EPIC-study. Hepatitis B and C virus status was measured in a nested case-control sub-set. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC (relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (CI): 2.09-5.87; P(trend)
Original languageEnglish
JournalInternational Journal of Cancer
Volume132
Issue3
Pages (from-to)645-57
Number of pages13
ISSN0020-7136
DOIs
Publication statusPublished - 1 Feb 2013

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