Christina C. Dahm

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Joanna L Clasen, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit
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  • Alicia K Heath, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit
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  • Heleen Van Puyvelde, WHO International Agency for Research on Cancer
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  • Inge Huybrechts, WHO International Agency for Research on Cancer
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  • Jin Young Park, WHO International Agency for Research on Cancer
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  • Pietro Ferrari, WHO International Agency for Research on Cancer
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  • Mattias Johansson, WHO International Agency for Research on Cancer
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  • Ghislaine Scelo, Department of Psychology, University of Turin & Neuroscience Institute of Turin, University of Turin
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  • Arve Ulvik, Department of Biology, University of Bergen, Bergen, Norway; Sars International Centre, Uni Research, University of Bergen, Bergen, Norway.
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  • Øivind Midttun, Bevital AS
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  • Per Magne Ueland, Department of Biology, University of Bergen, Bergen, Norway; Sars International Centre, Uni Research, University of Bergen, Bergen, Norway.
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  • Christina C Dahm
  • Jytte Halkjær, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
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  • Anja Olsen
  • Theron Johnson, German Cancer Research Center (DKFZ)
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  • Verena Katzke, German Cancer Research Center (DKFZ)
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  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
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  • Giovanna Masala, Institute for Cancer Research
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  • Francesco Segrado, Epidemiology and Prevention Unit, Milan, Italy.
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  • Maria Santucci de Magistris, AOU Federico II Naples, Italy.
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  • Carlotta Sacerdote, Division of Gastroenterology and Hepatology, Città della Salute e della Scienza Hospital, University of Turin, Italy.
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  • Marga C Ocké, Center for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
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  • Leila Luján-Barroso, Catalan Institute of Oncology-ICO
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  • Ana Ching-López, Escuela Andaluza de Salud Pública (EASP), Granada
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  • José María Huerta, Department of Epidemiology Research & Department of Infectious Disease Epidemiology and Prevention
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  • Eva Ardanaz, CIBER Epidemiologia y Salud Publica (CIBERESP).
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  • Pilar Amiano, Biodonostia Health Research Institute
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  • Ulrika Ericson, Department of Nephrology in Lund, Clinical Sciences Lund, Skåne University Hospital and Lund University, Lund, Sweden.
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  • Jonas Manjer, Department of Nephrology in Lund, Clinical Sciences Lund, Skåne University Hospital and Lund University, Lund, Sweden.
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  • Björn Gylling, Lund University, Malmö, Sweden; Umeå University, Umeå, Sweden.
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  • Ingegerd Johansson, Lund University, Malmö, Sweden; Umeå University, Umeå, Sweden.
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  • Elisabete Weiderpass, WHO International Agency for Research on Cancer
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  • Elio Riboli, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit
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  • Amanda J Cross, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit
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  • David C Muller, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit

BACKGROUND: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health.

OBJECTIVES: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics.

MEDTHODS: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP.

RESULTS: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.

CONCLUSIONS: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.

Original languageEnglish
JournalThe American Journal of Clinical Nutrition
ISSN0002-9165
DOIs
Publication statusE-pub ahead of print - 7 Apr 2021

Bibliographical note

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

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