Christian Kanstrup Holm

  1. 2023
  2. Published

    The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. / Vierbuchen, Tim; Agarwal, Shiuli; Johnson, John L et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, No. 1, 03.01.2023, p. e2213715120.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. 2022
  4. Published

    Plasmacytoid dendritic cells during COVID-19 : Ally or adversary? / van der Sluis, Renée Marije; Holm, Christian Kanstrup; Jakobsen, Martin Roelsgaard.

    In: Cell Reports, Vol. 40, No. 4, 111148, 07.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  5. Published

    TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. / van der Sluis, Renée M.; Cham, Lamin B.; Gris-Oliver, Albert et al.

    In: EMBO Journal, Vol. 41, No. 10, e109622, 05.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. / He, Wei; Henne, Antonia; Lauterbach, Mario et al.

    In: Nature Metabolism, Vol. 4, 2022, p. 524-533.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. 2021
  8. Published

    Nitro-fatty acids decrease type I interferons and monocyte chemoattractant protein 1 in ex vivo models of inflammatory arthritis. / Hansen, A. L.; Rahbek, L. S. J.; Sørensen, A. S. et al.

    In: BMC Immunology, Vol. 22, 77, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium. / Thyrsted, Jacob; Storgaard, Jacob; Blay-Cadanet, Julia et al.

    In: iScience, Vol. 24, No. 11, 11.2021, p. 103300.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern. / Carter-Timofte, Madalina Elena; Arulanandam, Rozanne; Kurmasheva, Naziia et al.

    In: ACS Infectious Diseases, Vol. 7, No. 11, 10.2021, p. 3034-3051.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Nrf2 in viral infection. / Herengt, Angela; Thyrsted, Jacob; Holm, Christian K.

    In: Antioxidants, Vol. 10, No. 9, 1491, 09.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  12. Published

    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. / Prabakaran, Thaneas; Troldborg, Anne; Kumpunya, Sarinya et al.

    In: EBioMedicine, Vol. 66, 103314, 06.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Virus-induced metabolic reprogramming and innate sensing hereof by the infected host. / Thyrsted, Jacob; Holm, Christian Kanstrup.

    In: Current Opinion in Biotechnology, Vol. 68, 04.2021, p. 44-50.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  14. Published

    Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways. / Blay-Cadanet, Julia; Pedersen, Alice; Holm, Christian Kanstrup.

    In: Frontiers in Immunology, Vol. 12, 635738, 02.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  15. Published

    Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro. / Svenningsen, Esben B; Thyrsted, Jacob; Blay-Cadanet, Julia et al.

    In: Antiviral Research, Vol. 185, 104988, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. 2020
  17. Published

    SARS-CoV-2 evades immune detection in alveolar macrophages. / Dalskov, Louise; Møhlenberg, Michelle; Thyrsted, Jacob et al.

    In: EMBO Reports, Vol. 21, No. 12, e51252, 12.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Slimhindeimmunitet i fordøjelseskanalen. / Vorup-Jensen, Thomas; Praetorius, Jeppe; Dige, Anders Kirch et al.

    Immunologi. ed. / Christian Kanstrup Holm. 2. ed. Roskilde : FADL's Forlag, 2020. p. 213-224.

    Research output: Contribution to book/anthology/report/proceedingBook chapterEducationpeer-review

  19. Published

    Author Correction : SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob et al.

    In: Nature Communications, Vol. 11, No. 1, 5419, 21.10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

  20. Published

    SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob et al.

    In: Nature Communications, Vol. 11, No. 1, 4938, 10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. 2019
  22. Published

    Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice. / Gunderstofte, Camilla; Iversen, Marie Beck; Peri, Suraj et al.

    In: Frontiers in Immunology, Vol. 10, 2101, 09.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    The uric acid crystal receptor Clec12A potentiates type I interferon responses. / Li, Kai; Neumann, Konstantin ; Duhan, Vikas et al.

    In: PNAS (Proceedings of the National Academy of Sciences of the United States of America), Vol. 116, No. 37, 09.2019, p. 18544-18549.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling. / Nandakumar, Ramya; Tschismarov, Roland; Meissner, Felix et al.

    In: Nature Microbiology, Vol. 4, 04.2019, p. 701-713.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    STING palmitoylation as a therapeutic target. / Hansen, Anne Louise; Mukai, Kojiro; Schopfer, Francisco J et al.

    In: Cellular & molecular immunology, Vol. 16, No. 3, 03.2019, p. 236-241.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  26. 2018
  27. Published

    Global transcriptional changes in response to cGAMP depend on STING in human THP-1 cells. / Hansen, Anne Louise; Brandtoft, Aske M; Nyegaard, Mette et al.

    In: Cellular & molecular immunology, Vol. 15, 11.2018, p. 983-985.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. / Olagnier, David; Brandtoft, Aske M; Gunderstofte, Camilla et al.

    In: Nature Communications, Vol. 9, No. 1, 3506, 29.08.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling. / Hansen, Anne Louise; Buchan, Gregory J; Rühl, Michael et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 33, 14.08.2018, p. E7768-E7775.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. 2017
  31. Published

    2017 Keystone Symposia at the Fairmont Banff Springs : Exploring new concepts in innate immunity and interferon signaling at the haunted castle. / Gunderstofte, Camilla; Holm, Christian K.; Olagnier, David.

    In: Cytokine & Growth Factor Reviews, Vol. 35, 06.2017, p. 1-6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  32. Published

    IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. / Jønsson, K L; Laustsen, A; Krapp, C et al.

    In: Nature Communications, Vol. 8, 14391, 10.02.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Slimhindeimmunitet. / Vorup-Jensen, Thomas; Dige, Anders Kirch; Holm, Christian Kanstrup.

    Immunologi. ed. / Christian K. Holm. 1. ed. København, 2017. p. 213-222.

    Research output: Contribution to book/anthology/report/proceedingBook chapterEducation

  34. 2016
  35. Published

    Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik et al.

    In: Nature Communications, Vol. 7, 10680, 19.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. 2015
  37. Published

    An innate antiviral pathway acting before interferons at epithelial surfaces. / Iversen, Marie B; Reinert, Line S; Thomsen, Martin K et al.

    In: Nature Immunology, 30.11.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Overexpression of MicroRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. / Rasmussen, Tue Kruse; Andersen, Thomas; Bak, Rasmus Otkjær et al.

    In: Arthritis research & therapy, Vol. 17, No. 1, 154, 09.06.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Toll-like receptor 2 and 4 induced IL-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity. / Kragstrup, Tue Wenzel; Andersen, Thomas; Holm, Christian et al.

    In: Clinical and Experimental Immunology, Vol. 180, No. 2, 05.2015, p. 233-242.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    NKT cell activation by local α-galactosylceramide administration decreases susceptibility to HSV-2 infection. / Iversen, Marie Beck; Jensen, Simon Kok; Hansen, Anne Louise et al.

    In: Immunobiology, 21.01.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. 2014
  42. Published

    Use of Immune Supressive Domains as Medicaments. / Laska, Magdalena Janina (Inventor); Bahrami, Shervin (Inventor); Holm, Christian Kanstrup (Inventor) et al.

    Patent No.: PCT/DK2014/050091. Apr 10, 2014.

    Research output: Patent

  43. Published

    T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses : Implications for Restriction of HIV Replication. / Berg, Randi K; Rahbek, Stine Hess; Kofod-Olsen, Emil et al.

    In: PLOS ONE, Vol. 9, No. 1, 2014, p. e84513.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. 2013
  45. Published

    Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors. / Horan, Kristy A; Hansen, Kathrine; Jakobsen, Martin Roelsgaard et al.

    In: Journal of Immunology, Vol. 190, No. 5, 01.03.2013, p. 2311-2329.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    DNA recognition in immunity and disease. / Holm, Christian K; Paludan, Søren R; Fitzgerald, Katherine A.

    In: Current Opinion in Immunology, Vol. 25, No. 1, 02.2013, p. 13-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections. / Kratholm, Sine K; Iversen, Marie B; Reinert, Line et al.

    In: PLOS ONE, Vol. 8, No. 12, 2013, p. e81790.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. 2012
  49. Published

    TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. / Reinert, Line S; Harder, Louis; Holm, Christian K et al.

    In: Journal of Clinical Investigation, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. / Holm, Christian K; Jensen, Søren B; Jakobsen, Martin Roelsgaard et al.

    In: Nature Immunology, Vol. 13, No. 8, 2012, p. 737-43.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. 2011
  52. Published

    Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes. / Rasmussen, Simon B; Horan, Kristy A; Holm, Christian K et al.

    In: Journal of Immunology, Vol. 187, No. 10, 2011, p. 5268-76.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  53. 2010
  54. Published

    Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings. / Andersen, Thomas; Rasmussen, Tue Kruse; Hvid, Malene et al.

    In: Rheumatology International, 30.11.2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  55. Published

    Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. / Rasmussen, Tue Kruse; Andersen, Thomas; Hvid, Malene et al.

    In: Journal of Rheumatology, Vol. 37, No. 10, 2010, p. 2014-20.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  56. 2009
  57. Published

    Selected Toll-like Receptors induce IL-21 synthesis by CD4+ T cells. / Holm, Christian.

    Aarhus Universitet, 2009.

    Research output: Book/anthology/dissertation/reportPh.D. thesis

  58. Published

    TLR3 Ligand Polyinosinic:Polycytidylic Acid Induces IL-17A and IL-21 Synthesis in Human Th Cells. / Holm, Christian; Petersen, Charlotte C; Hvid, Malene et al.

    In: Journal of Immunology, Vol. 183, 2009, p. 4422-31.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  59. 2008
  60. Published

    Increased expression of IL-22 and IL-22BP in rheumatoid arthritis and spondyloarthropathies. / Lindgreen, Esther; Kragstrup, Tue Wenzel; Holm, Christian et al.

    In: Arthritis & Rheumatism, Vol. 58, No. 9, 09.2008, p. S663-S664.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  61. Published

    The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy. / Kragstrup, Tue Wenzel; Otkjaer, Kristian; Holm, Christian et al.

    In: Cytokine, Vol. 41, No. 1, 2008, p. 16-23.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  62. 2006
  63. Published

    Interleukin-21 mRNA expression during virus infections. / Holm, Christian; Nyvold, C.G.; Paludan, Søren Riis et al.

    In: Cytokine, Vol. 33, 2006, p. 41-45.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  64. Published

    Interleukin-21 mRNA expression during virus infections. / Holm, Christian; Nyvold, Charlotte G; Paludan, Søren R et al.

    In: Cytokine, Vol. 33, No. 1, 2006, p. 41-5.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review