Department of Biomedicine

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Christian Brix Folsted Andersen

CD163 binding to haptoglobin-hemoglobin complexes involves a dual-point electrostatic receptor-ligand pairing

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

DOI

Formation of the haptoglobin (Hp)-hemoglobin (Hb) complex in human plasma leads to a high affinity recognition by the endocytic macrophage receptor CD163. A fast segregation of Hp-Hb from CD163 occurs at endosomal conditions (pH
Original languageEnglish
JournalJournal of Biological Chemistry
Volume288
Issue26
Pages (from-to)18834-41
Number of pages8
ISSN0021-9258
DOIs
Publication statusPublished - 28 Jun 2013

    Research areas

  • Amino Acid Sequence, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Binding Sites, Calcium, HEK293 Cells, Haptoglobins, Hemoglobins, Hemolysis, Humans, Ions, Ligands, Metals, Molecular Sequence Data, Mutagenesis, Site-Directed, Protein Binding, Receptors, Cell Surface, Recombinant Proteins, Sequence Homology, Amino Acid, Static Electricity, Surface Plasmon Resonance

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