Carmela Matrone

  1. 2019
  2. Published

    The Y 682 ENPTY 687 motif of APP : Progress and insights toward a targeted therapy for Alzheimer's disease patients. / Matrone, Carmela; Iannuzzi, Filomena; Annunziato, Lucio.

    In: Ageing Research Reviews, Vol. 52, 01.07.2019, p. 120-128.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. 2018
  4. Published

    Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells. / Kühn, Benjamin; Brat, Camilla; Fettel, Jasmin; Hellmuth, Nadine; Maucher, Isabelle V; Bulut, Ufuk; Hock, Katharina J; Grimmer, Jennifer; Manolikakes, Georg; Rühl, Michael; Kühn, Alessa; Zacharowski, Kai; Matrone, Carmela; Urbschat, Anja; Roos, Jessica; Steinhilber, Dieter; Maier, Thorsten J.

    In: Biochemical Pharmacology, Vol. 155, 09.2018, p. 48-60.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase : a possible key to future anti-leukotriene therapy. / Roos, Jessica; Peters, Marcus; Maucher, Isabelle V; Kühn, Benjamin; Fettel, Jasmin; Hellmuth, Nadine; Brat, Camilla; Sommer, Benita; Urbschat, Anja; Piesche, Matthias; Vogel, Anja; Proschak, Ewgenij; Blöcher, René; Buscato, Estel la; Häfner, Ann-Kathrin; Matrone, Carmela; Werz, Oliver; Heidler, Juliana; Wittig, Ilka; Angioni, Carlo; Geisslinger, Gerd; Parnham, Michael J; Zacharowski, Kai; Steinhilber, Dieter; Maier, Thorsten Jürgen.

    In: Antioxidants & Redox Signaling, Vol. 28, No. 14, 10.05.2018, p. 1265-1285.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2017
  7. Published

    Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418. / Maucher, Isabelle V; Rühl, Michael; Bm Kretschmer, Simon; Hofmann, Bettina; Kühn, Benjamin; Fettel, Jasmin; Vogel, Anja; Flügel, Karsten T; Manolikakes, Georg; Hellmuth, Nadine; Häfner, Ann-Kathrin; Golghalyani, Vahid; Ball, Ann-Katrin; Piesche, Matthias; Matrone, Carmela; Geisslinger, Gerd; Parnham, Michael J; Karas, Michael; Steinhilber, Dieter; Roos, Jessica; Maier, Thorsten J.

    In: Biochemical Pharmacology, Vol. 125, No. 1, 02.2017, p. 55–74.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. / Poulsen, Ebbe T; Iannuzzi, Filomena; Rasmussen, Helle F; Maier, Thorsten J; Enghild, Jan J; Jørgensen, Arne L; Matrone, Carmela.

    In: Frontiers in Molecular Neuroscience, Vol. 10, 2017, p. 59.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele. / Zollo, Alen; Allen, Zoe; Rasmussen, Helle F; Iannuzzi, Filomena; Shi, Yichen; Larsen, Agnete; Maier, Thorsten J; Matrone, Carmela.

    In: Neural Plasticity, Vol. 2017, 2017, p. 1892612.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. 2016
  11. Published

    Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease. / Matrone, Carmela; Dzamko, Nicolas; Madsen, Peder; Nyegaard, Mette; Pohlmann, Regina; Søndergaard, Rikke V; Lassen, Louise B; Andresen, Thomas L; Halliday, Glenda M; Jensen, Poul Henning; Nielsen, Morten S.

    In: PLOS ONE, Vol. 11, No. 8, 10.08.2016, p. e0160501.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs. / Jakobsen, Jannik E; Johansen, Marianne G; Schmidt, Mette; Liu, Ying; Li, Rong; Callesen, Henrik; Melnikova, Margarita; Habekost, Mette; Matrone, Carmela; Bouter, Yvonne; Bayer, Thomas A; Nielsen, Anders Lade; Duthie, Monika; Fraser, Paul E; Holm, Ida E; Jørgensen, Arne Lund.

    In: Journal of Alzheimer's Disease, Vol. 53, No. 4, 14.07.2016, p. 1617-30.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors : A basis for novel drugs targeting cancer cells? / Roos, Jessica; Grösch, Sabine; Werz, Oliver; Schröder, Peter; Ziegler, Slava; Fulda, Simone; Paulus, Patrick; Urbschat, Anja; Kühn, Benjamin; Maucher, Isabelle; Fettel, Jasmin; Vorup-Jensen, Thomas; Piesche, Matthias; Matrone, Carmela; Steinhilber, Dieter; Parnham, Michael J; Maier, Thorsten J.

    In: Pharmacology & Therapeutics, Vol. 157, 01.2016, p. 43-64.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    On the role of lipoxygenases in pathogenesis of cancer. / Roos, Jessica; Vorup-Jensen, Thomas; Matrone, Carmela; Maier, Thorsten J.; et al.

    In: Progress in inflammation research (submitted after invitation), Vol. Lipoxygenases in Inflammation, Progress in Inflammation Research, DOI 10.1007/978-3-319-27766-0_7, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. 2015
  16. Published

    New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies. / Poulsen, Ebbe Toftgaard; Larsen, Agnete; Zollo, Alen; Jørgensen, Arne Lund; Sanggaard, Kristian Wejse; Enghild, Jan J.; Matrone, Carmela.

    In: International Journal of Molecular Sciences (Online), 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    The Power of music on Alzheimer ’s Disease and the need to understand the underlying molecular mechanisms. / Matrone, Carmela; Brattico, Elvira.

    In: Journal of Alzheimer's disease and parkinsonism, Vol. 5, No. 3, 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction. / La Rosa, Luca Rosario; Perrone, Lorena; Nielsen, Morten Schallburg; Calissano, Pietro; Andersen, Olav Michael; Matrone, Carmela.

    In: Frontiers in Cellular Neuroscience, Vol. 9, 2015, p. 109.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. 2014
  20. Published

    Inflammatory risk factors and pathologies promoting Alzheimer`s disease progression : is RAGE the key? / Matrone, Carmela; Djelloul, Mehdi; Taglialatela, Giulio; Perrone, Lorena.

    In: Histology and Histopathology, 11.07.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    MiR-21 is an Ngf-Modulated MicroRNA That Supports Ngf Signaling and Regulates Neuronal Degeneration in PC12 Cells. / Montalban, Enrica; Mattugini, Nicola; Ciarapica, Roberta; Provenzano, Claudia; Savino, Mauro; Scagnoli, Fiorella; Prosperini, Gianluca; Carissimi, Claudia; Fulci, Valerio; Matrone, Carmela; Calissano, Pietro; Nasi, Sergio.

    In: NeuroMolecular Medicine, Vol. 16, No. 2, 06.2014, p. 415-30.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    Epigenetic modifications and potential new treatment targets in diabetic retinopathy. / Perrone, Lorena; Matrone, Carmela; Singh, Lalit P.

    In: Journal of Ophthalmology, Vol. 2014, 2014, p. 789120.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Erratum to "epigenetic modifications and potential new treatment targets in diabetic retinopathy". / Perrone, Lorena; Matrone, Carmela; Singh, Lalit P.

    In: Journal of Ophthalmology, Vol. 2014, 2014, p. 836450.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. 2013
  25. Published

    NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue. / Basso, Elisa; Matrone, Carmela.

    In: Cell Biology: Research & Therapy, 19.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    A new molecular explanation for age-related neurodegeneration : The Tyr682 residue of amyloid precursor protein. / Matrone, Carmela.

    In: BioEssays, 14.08.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Age-Related Changes of Hippocampal Synaptic Plasticity in AβPP-Null Mice are Restored by NGF through p75NTR. / La Rosa, Luca Rosario; Matrone, Carmela; Ferraina, Caterina; Panico, Maria Beatrice; Piccirilli, Silvia; Di Certo, Maria Grazia; Strimpakos, Georgios; Mercuri, Nicola Biagio; Calissano, Pietro; D'Amelio, Marcello; Nisticò, Robert.

    In: Journal of Alzheimer's Disease, 2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    Transcriptional Regulation of ncx1 Gene in the Brain. / Valsecchi, Valeria; Pignataro, Giuseppe; Sirabella, Rossana; Matrone, Carmela; Boscia, Francesca; Scorziello, Antonella; Sisalli, Maria Josè; Esposito, Elga; Zambrano, Nicola; Cataldi, Mauro; Di Renzo, Gianfranco; Annunziato, Lucio.

    Transcriptional Regulation of ncx1 Gene in the Brain. Vol. 961 2013. p. 137-45 (Advances in Experimental Medicine and Biology).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  29. 2012
  30. Published

    Erratum : Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity (Cell Death and Disease (2012) 3 (e339) Doi: 10.1038/cddis.2012.80). / Scarpi, D.; Cirelli, D.; Matrone, C.; Castronovo, G.; Rosini, P.; Occhiato, E. G.; RomanoF.; Bartali, L.; Clemente, A. M.; Bottegoni, G.; Cavalli, A.; De Chiara, G.; Bonini, P.; Calissano, P.; Palamara, A. T.; Garaci, E.; Torcia, M. G.; Guarna, A.; Cozzolino, F.

    In: Cell Death and Disease, Vol. 3, No. 9, e389, 01.09.2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debateResearchpeer-review

  31. Published

    Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. / Scarpi, D; Cirelli, D; Matrone, Carmela; Castronovo, G; Rosini, P; Occhiato, E G; Romano, F; Bartali, L; Clemente, A M; Bottegoni, G; Cavalli, Andrea; De Chiara, G; Bonini, P; Calissano, P; Palamara, A T; Garaci, E; Torcia, M G; Guarna, A; Cozzolino, F.

    In: Cell Death & Disease, Vol. 3, 2012, p. e389.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage. / Marolda, R; Ciotti, M T; Matrone, Carmela; Possenti, R; Calissano, P; Cavallaro, S; Severini, C.

    In: Neuropharmacology, Vol. 62, No. 5-6, 2012, p. 1954-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. / Matrone, Carmela; Luvisetto, Siro; La Rosa, Luca R; Tamayev, Robert; Pignataro, Annabella; Canu, Nadia; Yang, Li; Barbagallo, Alessia P M; Biundo, Fabrizio; Lombino, Franco; Zheng, Hui; Ammassari-Teule, Martine; D'Adamio, Luciano.

    In: Aging Cell, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2011
  35. Published

    APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. / Matrone, Carmela; Barbagallo, Alessia P M; La Rosa, Luca R; Florenzano, Fulvio; Ciotti, Maria T; Mercanti, Delio; Chao, Moses V; Calissano, Pietro; D'Adamio, Luciano.

    In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, No. 33, 2011, p. 11756-61.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. / Valsecchi, Valeria; Pignataro, Giuseppe; Del Prete, Annalisa; Sirabella, Rossana; Matrone, Carmela; Boscia, Francesca; Scorziello, Antonella; Sisalli, Maria Josè; Esposito, Elga; Zambrano, Nicola; Di Renzo, Gianfranco; Annunziato, Lucio.

    In: Stroke; a journal of cerebral circulation, Vol. 42, No. 3, 2011, p. 754-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. 2010
  38. Published

    Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF. / Calissano, P; Amadoro, G; Matrone, Carmela; Ciafrè, S; Marolda, R; Corsetti, V; Ciotti, M T; Mercanti, D; Di Luzio, A; Severini, C; Provenzano, C; Canu, N.

    In: Cell Death and Differentiation, Vol. 17, No. 7, 2010, p. 1126-33.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease. / Calissano, P; Matrone, Carmela; Amadoro, G.

    In: Developmental Neurobiology, Vol. 70, No. 5, 2010, p. 372-83.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. 2009
  41. Published

    Apoptosis and in vitro Alzheimer disease neuronal models. / Calissano, P; Matrone, Carmela; Amadoro, G.

    In: Communicative & Integrative Biology, Vol. 2, No. 2, 2009, p. 163-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. Published

    Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. / Matrone, Carmela; Marolda, R; Ciafrè, S; Ciotti, M T; Mercanti, D; Calissano, P.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 27, 2009, p. 11358-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. 2008
  44. Published

    Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells. / Matrone, Carmela; Di Luzio, Anna; Meli, Giovanni; D'Aguanno, Simona; Severini, Cinzia; Ciotti, Maria Teresa; Cattaneo, Antonino; Calissano, Pietro.

    In: Journal of Alzheimer's Disease, Vol. 13, No. 1, 2008, p. 81-96.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. / Matrone, Carmela; Ciotti, Maria Teresa; Mercanti, Delio; Marolda, Roberta; Calissano, Pietro.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 35, 2008, p. 13139-44.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. 2005
  47. Published

    Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors : Comparison with the effectiveness of cabergoline treatment. / Pivonello, Rosario; Matrone, Carmela; Filippella, Mariagiovanna; Cavallo, Luigi M.; Di Somma, Carolina; Cappabianca, Paolo; Colao, Annamaria; Annuziato, Lucio; Lombardi, Gaetano.

    In: Obstetrical and Gynecological Survey, Vol. 60, No. 1, 01.01.2005, p. 33-34.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debateResearchpeer-review

  48. Published

    Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurones and glial cells. / Irace, Carlo; Scorziello, Antonella; Maffettone, Carmen; Pignataro, Giuseppe; Matrone, Carmela; Adornetto, Annagrazia; Santamaria, Rita; Annunziato, Lucio; Colonna, Alfredo.

    In: Journal of Neurochemistry, Vol. 95, No. 5, 2005, p. 1321-31.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. 2004
  50. Published

    Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors : comparison with the effectiveness of cabergoline treatment. / Pivonello, Rosario; Matrone, Carmela; Filippella, Mariagiovanna; Cavallo, Luigi M; Di Somma, Carolina; Cappabianca, Paolo; Colao, Annamaria; Annunziato, Lucio; Lombardi, Gaetano.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 4, 2004, p. 1674-83.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. Published

    Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs. / Matrone, Carmela; Pivonello, R; Colao, A; Cappabianca, P; Cavallo, L M; Del Basso De Caro, M L; Taylor, John E.; Culler, M D; Lombardi, Gabriele; Di Renzo, G F; Annunziato, L.

    In: Neuroendocrinology, Vol. 79, No. 3, 2004, p. 142-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. Published

    HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion. / Matrone, Carmela; Pignataro, G; Molinaro, P; Irace, C; Scorziello, A; Di Renzo, G F; Annunziato, L.

    In: Journal of Neurochemistry, Vol. 90, No. 2, 2004, p. 368-78.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  53. Published

    Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. / Pignataro, Giuseppe; Gala, Rosaria; Cuomo, Ornella; Tortiglione, Anna; Giaccio, Lucia; Castaldo, Pasqualina; Sirabella, Rossana; Matrone, Carmela; Canitano, Adriana; Amoroso, Salvatore; Di Renzo, Gianfranco; Annunziato, Lucio.

    In: Stroke; a journal of cerebral circulation, Vol. 35, No. 11, 2004, p. 2566-70.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review