Bo Martin Bibby

Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Ulrik Dalgas
  • Martin Langeskov Christensen
  • A Skjerbæk, The Danish MS Hospitals in Ry and Haslev, Denmark., Denmark
  • E Jensen, The Danish MS Hospitals in Ry and Haslev, Denmark., Denmark
  • I Baert, REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences,Hasselt University, Diepenbeek, Belgium., Belgium
  • A Romberg, Masku Neurological Rehabilitation Center, Masku, Finland., Finland
  • C Santoyo Medina, Hospital de Dia de Barcelona CEMCat, Spain or MS Center of Catalonia (Cemcat), Vall Hebron University Hospital, Universitat Autònoma de Barcelona, Spain., Spain
  • B Gebara, National MS Center, Melsbroek, Belgium., Belgium
  • B Maertens de Noordhout, Center Neurologique et de Réadaptation Fonctionelle, Fraiture-en-Condroz, Belgium., Belgium
  • K Knuts, Rehabilitation and MS Center Overpelt, Belgium., Belgium
  • F Béthoux, The Mellen Center for Multiple Sclerosis Treatment and Research, The Cleveland Clinic, Cleveland, OH, USA., United States
  • K Rasova, Department of Rehabilitation, Third Faculty of Medicine, Charles University, Czech Republic., Czech Republic
  • D Severijns, REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences,Hasselt University, Diepenbeek, Belgium., Belgium
  • Bo Martin Bibby
  • A Kalron, Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Israel
  • B Norman, Department of Health and Care Sciences, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway; Department of Physiotherapy, Nordland Hospital Trust, Bodø, Norway., Norway
  • F Van Geel, REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences,Hasselt University, Diepenbeek, Belgium., Belgium
  • I Wens, REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences,Hasselt University, Diepenbeek, Belgium., Belgium
  • P Feys, REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences,Hasselt University, Diepenbeek, Belgium., Belgium

BACKGROUND: The relationship between fatigue impact and walking capacity and perceived ability in patients with multiple sclerosis (MS) is inconclusive in the existing literature. A better understanding might guide new treatment avenues for fatigue and/or walking capacity in patients with MS.

OBJECTIVE: To investigate the relationship between the subjective impact of fatigue and objective walking capacity as well as subjective walking ability in MS patients.

METHODS: A cross-sectional multicenter study design was applied. Ambulatory MS patients (n = 189, age: 47.6 ± 10.5 years; gender: 115/74 women/men; Expanded Disability Status Scale (EDSS): 4.1 ± 1.8 [range: 0-6.5]) were tested at 11 sites. Objective tests of walking capacity included short walking tests (Timed 25-Foot Walk (T25FW), 10-Metre Walk Test (10mWT) at usual and fastest speed and the timed up and go (TUG)), and long walking tests (2- and 6-Minute Walk Tests (MWT). Subjective walking ability was tested applying the Multiple Sclerosis Walking Scale-12 (MSWS-12). Fatigue impact was measured by the self-reported modified fatigue impact scale (MFIS) consisting of a total score (MFIStotal) and three subscales (MFISphysical, MFIScognitiveand MFISpsychosocial). Uni- and multivariate regression analysis were performed to evaluate the relation between walking and fatigue impact.

RESULTS: MFIStotalwas negatively related with long (6MWT, r = -0.14, p = 0.05) and short composite (TUG, r = -0.22, p = 0.003) walking measures. MFISphysicalshowed a significant albeit weak relationship to walking speed in all walking capacity tests (r = -0.22 to -0.33, p < .0001), which persisted in the multivariate linear regression analysis. Subjective walking ability (MSWS-12) was related to MFIStotal(r = 0.49, p < 0.0001), as well as to all other subscales of MFIS (r = 0.24-0.63, p < 0.001), showing stronger relationships than objective measures of walking.

CONCLUSIONS: The physical impact of fatigue is weakly related to objective walking capacity, while general, physical, cognitive and psychosocial fatigue impact are weakly to moderately related to subjective walking ability, when analysed in a large heterogeneous sample of MS patients.

Original languageEnglish
JournalJournal of the Neurological Sciences
Volume387
Pages (from-to)179-186
Number of pages8
ISSN0022-510X
DOIs
Publication statusPublished - 15 Apr 2018

    Research areas

  • fatigue, multiple sclerosis, walking capacity

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