Bo Bergholt

The influence of the input function on quantitative rCBF by the Xe/CT method

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • G von Oettingen, Dept. of Neurosurgery, Aarhus University Hospital, Denmark.
  • ,
  • B Bergholt
  • L Ostergaard
  • ,
  • M Rasmussen
  • C Gyldensted
  • ,
  • J Astrup

Measurements of rCBF by the Xe/CT method are based on the assumption of identity between the end-tidal xenon curve which is applied as input function, and the arterial xenon curve being the true input function to the brain. In this study corresponding end-tidal and arterial xenon curves were measured in an experimental animal model (part 1) and in 5 patients with traumatic brain injury (part 2) and used for rCBF calculation. In both studies rCBF was underestimated by using the end-tidal xenon concentration curve as brain input function. In part 1 rCBF underestimation was depended on pulmonary gas exchange; high or low levels of rCBF; tissue type; and xenon inhalation protocols. In part 2 the mean rCBF underestimation was 18.8 +/- 8.3%. In conclusion, non-invasive estimate of the input function should be considered as a source of error when defining quantitative blood flow values e.g. the flow thresholds of ischaemic infarction.

Original languageEnglish
JournalKeio Journal of Medicine
Volume49 Suppl 1
Pages (from-to)A11-5
ISSN0022-9717
Publication statusPublished - Feb 2000

    Research areas

  • Animals, Brain Injuries, Cerebrovascular Circulation, Humans, Lung Injury, Male, Swine, Tomography, X-Ray Computed, Xenon, Journal Article, Research Support, Non-U.S. Gov't

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