Bo Bergholt

The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis

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The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis. / Jensen, Thorbjørn Søren Rønn; Andersen-Ranberg, Nina; Poulsen, Frantz Rom; Bergholt, Bo; Hundsholt, Torben; Fugleholm, Kåre.

In: Acta Neurochirurgica, Vol. 162, No. 9, 09.2020, p. 2007-2013.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jensen, TSR, Andersen-Ranberg, N, Poulsen, FR, Bergholt, B, Hundsholt, T & Fugleholm, K 2020, 'The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis', Acta Neurochirurgica, vol. 162, no. 9, pp. 2007-2013. https://doi.org/10.1007/s00701-020-04472-w

APA

Jensen, T. S. R., Andersen-Ranberg, N., Poulsen, F. R., Bergholt, B., Hundsholt, T., & Fugleholm, K. (2020). The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis. Acta Neurochirurgica, 162(9), 2007-2013. https://doi.org/10.1007/s00701-020-04472-w

CBE

Jensen TSR, Andersen-Ranberg N, Poulsen FR, Bergholt B, Hundsholt T, Fugleholm K. 2020. The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis. Acta Neurochirurgica. 162(9):2007-2013. https://doi.org/10.1007/s00701-020-04472-w

MLA

Vancouver

Jensen TSR, Andersen-Ranberg N, Poulsen FR, Bergholt B, Hundsholt T, Fugleholm K. The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis. Acta Neurochirurgica. 2020 Sep;162(9):2007-2013. https://doi.org/10.1007/s00701-020-04472-w

Author

Jensen, Thorbjørn Søren Rønn ; Andersen-Ranberg, Nina ; Poulsen, Frantz Rom ; Bergholt, Bo ; Hundsholt, Torben ; Fugleholm, Kåre. / The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis. In: Acta Neurochirurgica. 2020 ; Vol. 162, No. 9. pp. 2007-2013.

Bibtex

@article{30c5ed5d169c4e94be858114d9a65dee,
title = "The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis",
abstract = "INTRODUCTION: Chronic subdural hematomas (CSDH) show different radiological characteristics on CT scans at the time of diagnosis. The reason for this is largely unknown. We hypothesize that the imaging characteristics reflect a time-linked pathophysiological evolution. We therefore conducted a retrospective study to examine a possible relation between the hematoma age and the radiological subtype of a CSDH.METHODS: Demographic data on patients with CSDH were retrieved from a Danish national cohort from 2010 to 2012. CT scans obtained on admission to a neurosurgical department were categorized as homogenous, separated, mixed, or membranous hematoma subtypes. The time from a known date of head injury to time of diagnostic CT was defined as hematoma age. The hematoma age was correlated to radiological hematoma subtype at the time of diagnosis by analysis of variance testing.RESULTS: In total, 543 patients were analyzed for hematoma age and classified in the following hematoma subtypes: 231 homogenous, 44 separated, 119 mixed, and 149 membranous. Patients with homogenous, separated, mixed, and membranous hematoma subtypes had a median interval of 37, 36, 40, and 60 days from head injury to diagnostic CT. We found that membranous hematoma is significantly older than other subtypes. Comparison between the other radiological subtypes showed no statistical hematoma age difference. The distribution of radiological subtypes in 590 patients without a known head injury was similar to that of patients with a known head injury. Additionally, we found that hematoma age was significantly younger for patients on antiplatelet medication.CONCLUSION: In this large national cohort, patients with membranous CSDH had a significantly longer interval between head injury and diagnosis compared to other radiological subtypes. This indicates that the radiological appearance of CSDH evolves over time, causing an alteration from different early radiological subtypes to a radiological subtype with membranes.CLINICAL TRIAL REGISTRATION NUMBER: The study was approved by the Danish Data Protection Agency (journal no.30-1145).",
author = "Jensen, {Thorbj{\o}rn S{\o}ren R{\o}nn} and Nina Andersen-Ranberg and Poulsen, {Frantz Rom} and Bo Bergholt and Torben Hundsholt and K{\aa}re Fugleholm",
year = "2020",
month = sep,
doi = "10.1007/s00701-020-04472-w",
language = "English",
volume = "162",
pages = "2007--2013",
journal = "Acta Neurochirurgica",
issn = "0001-6268",
publisher = "Springer Wien",
number = "9",

}

RIS

TY - JOUR

T1 - The Danish Chronic Subdural Hematoma Study-comparison of hematoma age to the radiological appearance at time of diagnosis

AU - Jensen, Thorbjørn Søren Rønn

AU - Andersen-Ranberg, Nina

AU - Poulsen, Frantz Rom

AU - Bergholt, Bo

AU - Hundsholt, Torben

AU - Fugleholm, Kåre

PY - 2020/9

Y1 - 2020/9

N2 - INTRODUCTION: Chronic subdural hematomas (CSDH) show different radiological characteristics on CT scans at the time of diagnosis. The reason for this is largely unknown. We hypothesize that the imaging characteristics reflect a time-linked pathophysiological evolution. We therefore conducted a retrospective study to examine a possible relation between the hematoma age and the radiological subtype of a CSDH.METHODS: Demographic data on patients with CSDH were retrieved from a Danish national cohort from 2010 to 2012. CT scans obtained on admission to a neurosurgical department were categorized as homogenous, separated, mixed, or membranous hematoma subtypes. The time from a known date of head injury to time of diagnostic CT was defined as hematoma age. The hematoma age was correlated to radiological hematoma subtype at the time of diagnosis by analysis of variance testing.RESULTS: In total, 543 patients were analyzed for hematoma age and classified in the following hematoma subtypes: 231 homogenous, 44 separated, 119 mixed, and 149 membranous. Patients with homogenous, separated, mixed, and membranous hematoma subtypes had a median interval of 37, 36, 40, and 60 days from head injury to diagnostic CT. We found that membranous hematoma is significantly older than other subtypes. Comparison between the other radiological subtypes showed no statistical hematoma age difference. The distribution of radiological subtypes in 590 patients without a known head injury was similar to that of patients with a known head injury. Additionally, we found that hematoma age was significantly younger for patients on antiplatelet medication.CONCLUSION: In this large national cohort, patients with membranous CSDH had a significantly longer interval between head injury and diagnosis compared to other radiological subtypes. This indicates that the radiological appearance of CSDH evolves over time, causing an alteration from different early radiological subtypes to a radiological subtype with membranes.CLINICAL TRIAL REGISTRATION NUMBER: The study was approved by the Danish Data Protection Agency (journal no.30-1145).

AB - INTRODUCTION: Chronic subdural hematomas (CSDH) show different radiological characteristics on CT scans at the time of diagnosis. The reason for this is largely unknown. We hypothesize that the imaging characteristics reflect a time-linked pathophysiological evolution. We therefore conducted a retrospective study to examine a possible relation between the hematoma age and the radiological subtype of a CSDH.METHODS: Demographic data on patients with CSDH were retrieved from a Danish national cohort from 2010 to 2012. CT scans obtained on admission to a neurosurgical department were categorized as homogenous, separated, mixed, or membranous hematoma subtypes. The time from a known date of head injury to time of diagnostic CT was defined as hematoma age. The hematoma age was correlated to radiological hematoma subtype at the time of diagnosis by analysis of variance testing.RESULTS: In total, 543 patients were analyzed for hematoma age and classified in the following hematoma subtypes: 231 homogenous, 44 separated, 119 mixed, and 149 membranous. Patients with homogenous, separated, mixed, and membranous hematoma subtypes had a median interval of 37, 36, 40, and 60 days from head injury to diagnostic CT. We found that membranous hematoma is significantly older than other subtypes. Comparison between the other radiological subtypes showed no statistical hematoma age difference. The distribution of radiological subtypes in 590 patients without a known head injury was similar to that of patients with a known head injury. Additionally, we found that hematoma age was significantly younger for patients on antiplatelet medication.CONCLUSION: In this large national cohort, patients with membranous CSDH had a significantly longer interval between head injury and diagnosis compared to other radiological subtypes. This indicates that the radiological appearance of CSDH evolves over time, causing an alteration from different early radiological subtypes to a radiological subtype with membranes.CLINICAL TRIAL REGISTRATION NUMBER: The study was approved by the Danish Data Protection Agency (journal no.30-1145).

U2 - 10.1007/s00701-020-04472-w

DO - 10.1007/s00701-020-04472-w

M3 - Journal article

C2 - 32594246

VL - 162

SP - 2007

EP - 2013

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

IS - 9

ER -