Projects per year
Personal profile
Research
Our research focus is to investigate how the genetic composition of cancer cells affect anti-cancer treatment. In addition, we study the genetic changes occurring in cancer cells when they become resistant to treatment. To achieve this goal, we investigate circulating tumor DNA (ctDNA), which are small fragments of DNA released from tumor cells to the blood stream. Our aim is to use ctDNA to identify the patients that will respond to different anti-cancer treatments. In addition, we investigate if ctDNA can be used to monitor the treatment of patients, and in particular to identify resistance to treatment at an earlier time point than is normally possible.
The main research focus is lung cancer and benefits from a long-lasting collaboration with ass. prof. Peter Meldgaard, Dept. of Oncology, Aarhus University Hospital. We investigate the potential of ctDNA to monitor the effect of several anti-cancer treatments targeting oncogenes present in lung cancer. We have already demonstrated that ctDNA can identify lung cancer patients that will respond to EGFR and ALK directed treatment, and shown that ctDNA can give information on when resistance to treatment has developed. This has now been extended to immunotherapy of lung cancer where we have demonstrated the potential of ctDNA to identify patients responding to treatment.
We are now extending our studies to several national and international clinical studies where we investigate the potential of ctDNA to predict treatment effect. In addition, we are investigating if the ctDNA present at the time of resistance to treatment hold information that can be used to suggest new treatments overcoming resistance. In these trials lung cancer patients are treated at several oncological centers, and ctDNA is analyzed in our research group.
A new avenue of our research is the new method cfCHIP developed in collaboration with ass. prof. Anders Lade Nielsen, Aarhus University. Based on studies of ctDNA in a blood sample this technique can give information on the transcriptional activity of genes in the lung tumor.
Areas of expertise
- Cancer research
- Circulating tumor DNA
- Epigenetics of tumor DNA
- Targeted cancer treatment
- Lung cancer
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Circulating tumor cells and tumor DNA - patient-specific biomarkers for clinical decision support and tailored relapse diagnostics in neuroendocrine tumors and hepatocellular carcinoma
Oversø, S. K. (Participant), Kelsen, J. (Participant), Sørensen, B. S. (Participant), Weber, B. (Participant), Grønbæk, H. (Participant) & Tabaksblat, E. M. (Participant)
01/11/2016 → …
Project: Research
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ctDNA as marker for response to treatment of lungcancer
Sørensen, B. S. (PI) & Meldgaard, P. (PI)
24/01/2012 → 01/01/2027
Project: Research
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ctDNA as marker of residual disease in lung cancer
Sørensen, B. S. (PI) & Meldgaard, P. (PI)
24/01/2012 → 24/06/2027
Project: Research
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Virology in Cancer
Lindved, S. B. (Project manager), Steiniche, T. (Participant), Blaakær, J. (Participant), Fuglsang, K. (Participant), Høgdall, E. (Participant), Lenz, S. (Participant), Strube, M. L. (Participant), Lindegaard, J. C. (Participant), Sørensen, B. S. (Participant) & Stougaard, M. (Participant)
01/02/2018 → 30/06/2023
Project: Research
Research output
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Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
Al Bakir, M., Reading, J. L., Gamble, S., Rosenthal, R., Uddin, I., Rowan, A., Przewrocka, J., Rogers, A., Wong, Y. N. S., Bentzen, A. K., Veeriah, S., Ward, S., Garnett, A. T., Kalavakur, P., Martínez-Ruiz, C., Puttick, C., Huebner, A., Cook, D. E., Moore, D. A. & Abbosh, C. & 21 others, , 27 Mar 2025, In: Nature. 639, p. 1052-1059 8 p., 216.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
ctDNA can detect minimal residual disease in curative treated non-small cell lung cancer patients using a tumor agnostic approach
Rosenlund, L., Guldbrandsen, K., Ahlborn, L. B., Bloch, M., Skougaard, K., Albrecht-Beste, E., Nellemann, H. M., Krakauer, M., Gørtz, P. M., Fledelius, J., Nielsen, A. L., Holdgaard, P. C., Nielsen, S. S., Grüner, J. M., Højsgaard, A., Petersen, R. H., Møller, L. B., Dahl, M., Frank, M. S. & Ehlers, J. H. & 23 others, , May 2025, In: Lung Cancer. 203, 108528.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Development and validation of an LC-MS/MS method for quantification of Osimertinib and its two metabolites AZ7550 and AZ5104 in human plasma including long-time storage
Greibe, E., Sorensen, B., Meldgaard, P. & Hoffmann-Lücke, E., 15 Mar 2025, In: Journal of Pharmaceutical and Biomedical Analysis. 255, 116662.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
1 Citation (Scopus) -
In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade
Antonsen, K. W., Jensen, A. G., Sorensen, B., Etzerodt, A., Moestrup, S. K. & Møller, H. J., 1 Mar 2025, In: Cellular Immunology. 409-410, 104932.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
A five-gene qPCR signature can classify type 2 asthma comparably to microscopy of induced sputum from severe asthma patients
Toennesen, B., Schmid, J. M., Sørensen, B. S., Fricker, M. & Hoffmann, H. J. H., 2024, In: European Clinical Respiratory Journal. 11, 1, 2293318.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Activities
- 3 Participation in or organisation af a conference
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Molekylær profilering - targeteret kræftbehandling
Sørensen, B. S. (Participant)
24 Nov 2005 → 25 Nov 2005Activity: Participating in or organising an event types › Participation in or organisation af a conference
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Growth Factor Receptor Tyrosine Kinases in Mitogenesis Morphogenesis & Tumorigenesis
Sørensen, B. S. (Participant)
6 Aug 2005 → 11 Aug 2005Activity: Participating in or organising an event types › Participation in or organisation af a conference
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Dansk Selskab for Cancerforskning, 18. årsmøde
Sørensen, B. S. (Participant)
4 May 2005Activity: Participating in or organising an event types › Participation in or organisation af a conference