Anne-Mette Lange

Treatment of ADHD in adults–prevalence of discontinuation and associated factors–results from a cross-sectional analysis of Danish register data

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Treatment of ADHD in adults–prevalence of discontinuation and associated factors–results from a cross-sectional analysis of Danish register data. / Mohr-Jensen, Christina; Lange, Anne Mette; Thomsen, Per Hove; Daley, David.

In: Nordic Journal of Psychiatry, Vol. 74, No. 7, 2020, p. 479-488.

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@article{16f7ffcff56340c08eab98b6abb54784,
title = "Treatment of ADHD in adults–prevalence of discontinuation and associated factors–results from a cross-sectional analysis of Danish register data",
abstract = "Background: A growing number of adults are receiving pharmacological treatment for ADHD but a sizable proportion also discontinues or have gaps in treatment. The primary aims of this study were to identify how many patients treated for ADHD in adulthood, have at least one event of discontinuation in treatment and to identify possible associated variables. Methods: Within the Danish population aged 18–60 years on the 1st of January 2013, we identified the number of individuals who had been prescribed ADHD-medication at least once during the 1st of January 2002–31st of December 2013 using Danish register data. Among those who filed more than one prescription, treatment discontinuation was defined as having more than 211 days between two prescriptions. In crude and adjusted logistic regression analysis, we explored potential associations to discontinuation for variables such as gender and age at treatment initiation. Results: In a population, if N = 3,165,844 individuals, n = 42,892 had received at least one prescription for ADHD medication. Among those with more than one prescription (N = 38,289), 29.4% had discontinued their treatment at least once, according to our definition of treatment discontinuation. ADHD treatment discontinuation was associated with being male, unemployment, lower educational attainment, receiving incapacity benefits and younger age at treatment initiation (p < 0.001). Conclusions: A large proportion of individuals treated for ADHD had at least one discontinuation of treatment according to our definition. Although the present study does not allow for investigating the direction of these effects, nor whether some patients later resumed treatment, having at least one discontinuation was associated with a range of variables relating to e.g. age and gender, and provides an emerging profile for clinicians of patients more likely to discontinue.",
keywords = "ADHD, compliance, discontinuation, stability, treatment",
author = "Christina Mohr-Jensen and Lange, {Anne Mette} and Thomsen, {Per Hove} and David Daley",
year = "2020",
doi = "10.1080/08039488.2020.1740781",
language = "English",
volume = "74",
pages = "479--488",
journal = "Nordic Journal of Psychiatry. Supplement",
issn = "0803-9496",
publisher = "Taylor & Francis A B",
number = "7",

}

RIS

TY - JOUR

T1 - Treatment of ADHD in adults–prevalence of discontinuation and associated factors–results from a cross-sectional analysis of Danish register data

AU - Mohr-Jensen, Christina

AU - Lange, Anne Mette

AU - Thomsen, Per Hove

AU - Daley, David

PY - 2020

Y1 - 2020

N2 - Background: A growing number of adults are receiving pharmacological treatment for ADHD but a sizable proportion also discontinues or have gaps in treatment. The primary aims of this study were to identify how many patients treated for ADHD in adulthood, have at least one event of discontinuation in treatment and to identify possible associated variables. Methods: Within the Danish population aged 18–60 years on the 1st of January 2013, we identified the number of individuals who had been prescribed ADHD-medication at least once during the 1st of January 2002–31st of December 2013 using Danish register data. Among those who filed more than one prescription, treatment discontinuation was defined as having more than 211 days between two prescriptions. In crude and adjusted logistic regression analysis, we explored potential associations to discontinuation for variables such as gender and age at treatment initiation. Results: In a population, if N = 3,165,844 individuals, n = 42,892 had received at least one prescription for ADHD medication. Among those with more than one prescription (N = 38,289), 29.4% had discontinued their treatment at least once, according to our definition of treatment discontinuation. ADHD treatment discontinuation was associated with being male, unemployment, lower educational attainment, receiving incapacity benefits and younger age at treatment initiation (p < 0.001). Conclusions: A large proportion of individuals treated for ADHD had at least one discontinuation of treatment according to our definition. Although the present study does not allow for investigating the direction of these effects, nor whether some patients later resumed treatment, having at least one discontinuation was associated with a range of variables relating to e.g. age and gender, and provides an emerging profile for clinicians of patients more likely to discontinue.

AB - Background: A growing number of adults are receiving pharmacological treatment for ADHD but a sizable proportion also discontinues or have gaps in treatment. The primary aims of this study were to identify how many patients treated for ADHD in adulthood, have at least one event of discontinuation in treatment and to identify possible associated variables. Methods: Within the Danish population aged 18–60 years on the 1st of January 2013, we identified the number of individuals who had been prescribed ADHD-medication at least once during the 1st of January 2002–31st of December 2013 using Danish register data. Among those who filed more than one prescription, treatment discontinuation was defined as having more than 211 days between two prescriptions. In crude and adjusted logistic regression analysis, we explored potential associations to discontinuation for variables such as gender and age at treatment initiation. Results: In a population, if N = 3,165,844 individuals, n = 42,892 had received at least one prescription for ADHD medication. Among those with more than one prescription (N = 38,289), 29.4% had discontinued their treatment at least once, according to our definition of treatment discontinuation. ADHD treatment discontinuation was associated with being male, unemployment, lower educational attainment, receiving incapacity benefits and younger age at treatment initiation (p < 0.001). Conclusions: A large proportion of individuals treated for ADHD had at least one discontinuation of treatment according to our definition. Although the present study does not allow for investigating the direction of these effects, nor whether some patients later resumed treatment, having at least one discontinuation was associated with a range of variables relating to e.g. age and gender, and provides an emerging profile for clinicians of patients more likely to discontinue.

KW - ADHD

KW - compliance

KW - discontinuation

KW - stability

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=85088038481&partnerID=8YFLogxK

U2 - 10.1080/08039488.2020.1740781

DO - 10.1080/08039488.2020.1740781

M3 - Journal article

C2 - 32664781

AN - SCOPUS:85088038481

VL - 74

SP - 479

EP - 488

JO - Nordic Journal of Psychiatry. Supplement

JF - Nordic Journal of Psychiatry. Supplement

SN - 0803-9496

IS - 7

ER -