Anne Gitte Rasmussen Loft

Type I and III collagen turnover is increased in axial spondyloarthritis and psoriatic arthritis. Associations with disease activity and diagnostic capacity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Natasja Stæhr Gudmann, Nord Biosci, Biomarkers & Res
  • ,
  • Anne Sofie Siebuhr, Nord Biosci, Biomarkers & Res
  • ,
  • Anne Friesgaard Christensen, Vejle Hosp, Dept Rheumatol
  • ,
  • Leif Ejstrup, Esbjerg Cent Hosp, Dept Rheumatol
  • ,
  • Grith Lykke Sørensen, Univ Southern Denmark, University of Southern Denmark, Inst Mol Med
  • ,
  • Anne Gitte Loft
  • Morten Asser Karsdal, Nord Biosci, Biomarkers & Res
  • ,
  • Anne-Christine Bay-Jensen, Nord Biosci, Biomarkers & Res
  • ,
  • Heidi Lausten Munk, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol
  • ,
  • Peter Junker, Odense Univ Hosp, Odense University Hospital, Dept Rheumatol

Objective

To investigate the turnover of type I and III collagen by neo-epitope markers in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA).

Methods

Patients with PsA (n=101) or axSpA (n=110) and healthy subjects (n=120) were included. Demographic and clinical data were recorded. Markers of type I and III collagen were quantified by RIA (ICTP) or ELISA (C1M and C3M). Non-parametric statistics were applied for intergroup comparisons and correlation studies. The diagnostic potential of these marker molecules was assessed by ROC analysis.

Results

C1M and C3M, which originate from soft connective tissues, were significantly higher in axSpA and PsA as compared with healthy control subjects. CIM and C3M correlated with ASDAS and DAS28. Overall, ICTP, which arises from bone degradation, did not differ between disease versus healthy. However, ICTP was lower in HLA-B27 positive than in HLA-B27 negative patients with axSpA. There was no association between bone and soft connective tissue collagen I markers (ICTP and C1M), while C1M and C3M were highly correlated (p

Conclusion

Type I and III collagen remodelling in soft connective tissue is increased in axSpA and PsA and associates with disease activity. Bone collagen degradation is lower in HLA-B27 positive compared with HLA-B27 negative axSpA, which may represent an aspect of enhanced enthesopathic bone proliferation in HLA-B27 carriers. C1M and C3M distinguish well between healthy and diseased individuals.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume35
Issue4
Pages (from-to)653-659
Number of pages7
ISSN0392-856X
Publication statusPublished - 28 Feb 2017

    Research areas

  • spondyloarthropathies, axial spondyloarthritis, psoriatic arthritis, biomarkers, collagens, SOCIETY CLASSIFICATION CRITERIA, CARBOXY-TERMINAL TELOPEPTIDE, EARLY ANKYLOSING-SPONDYLITIS, BONE-FORMATION, RHEUMATOID-ARTHRITIS, TISSUE TURNOVER, JOINT TISSUE, OSTEOARTHRITIS, BIOMARKERS, CARTILAGE

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