Anne Gitte Rasmussen Loft

Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic postmenopausal women: a dose response study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • K Brixen, Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
  • ,
  • M Kassem
  • ,
  • H K Nielsen
  • ,
  • A G Loft
  • A Flyvbjerg
  • ,
  • L Mosekilde

To investigate the potential use of growth hormone (GH) in Activate-Depress-Free-Repeat treatment of postmenopausal osteoporosis, we measured changes in serum levels of biochemical markers of bone turnover, insulin-like growth factor-I (IGF-I), calciotropic hormones, and bone mineral density in 40 postmenopausal women with osteopenia (ages 52-73 years) in response to 7 days of treatment with either placebo or GH (0.05, 0.10, or 0.20 IU/kg/day) administered subcutaneously in the evening. GH treatment increased serum osteocalcin (p < 0.01) and C-terminal type-I procollagen propeptide (p < 0.01) and also serum levels of type-I collagen telopeptide (p < 0.001), fasting urinary hydroxyproline/creatinine (p < 0.05), pyridinoline/creatinine (p < 0.05), and deoxypyridinoline/creatinine (p < 0.01) in a dose-dependent fashion. Even the lowest dose of GH tested induced a significant increase in these parameters; however, the effects were transient lasting only 1-2 weeks. In the highest dose group, however, a somewhat prolonged effect (30 days) on serum osteocalcin was observed. Furthermore, GH increased serum levels of IGF-I, insulin, and tri-iodothyronin. No effect on serum 1,25-dihydroxyvitamin D3 or parathyroid hormone could be demonstrated. Adverse effects were mainly related to fluid retention. They were clearly dose-dependent and rapidly reversible. In conclusion, short-term GH treatment stimulates bone formation and bone resorption in postmenopausal women with osteopenia.

Original languageEnglish
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume10
Issue12
Pages (from-to)1865-74
Number of pages10
ISSN0884-0431
DOIs
Publication statusPublished - Dec 1995

    Research areas

  • Aged, Biomarkers/blood, Bone Density/drug effects, Bone Development/drug effects, Bone Diseases, Metabolic/drug therapy, Bone Resorption/drug therapy, Calcitriol/blood, Dose-Response Relationship, Drug, Female, Growth Hormone/administration & dosage, Humans, Injections, Subcutaneous, Insulin/blood, Insulin-Like Growth Factor I/metabolism, Middle Aged, Osteoblasts/cytology, Osteocalcin/blood, Osteoclasts/cytology, Osteoporosis, Postmenopausal/drug therapy, Peptide Fragments/blood, Procollagen/blood, Thyroid Hormones/blood

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