Anne Gitte Rasmussen Loft

Determination of maternal serum acetylcholinesterase in pregnancies with fetal neural tube defects

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

We have investigated the occurrence of acetylcholinesterase (AChE) (E.C. 3.1.1.7) in fetal serum, amniotic fluid and maternal serum using an immuno-chemical assay-technique employing both polyclonal and monoclonal antibodies. Fetal serum had increased amounts of AChE, which is due to an increase in the 10.5S form of the enzyme. This form was also found in amniotic fluids of pregnancies with a fetal neural tube defect (NTD), but not in normal amniotic fluid. The increase in amniotic fluid AChE was however, not reflected in the maternal serum.

Original languageEnglish
JournalPrenatal Diagnosis
Volume7
Issue2
Pages (from-to)75-9
Number of pages5
ISSN0197-3851
Publication statusPublished - Feb 1987

    Research areas

  • Acetylcholinesterase/blood, Amniotic Fluid/enzymology, Antibodies, Monoclonal, Female, Fetal Blood/enzymology, Gestational Age, Humans, Immunoassay, Neural Tube Defects/enzymology, Pregnancy

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