Anne Gitte Rasmussen Loft

Cartilage collagen type II seromarker patterns in axial spondyloarthritis and psoriatic arthritis: associations with disease activity, smoking and HLA-B27

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Heidi Lausten Munk, Department of Rheumatology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark. heidi.munk@rsyd.dk.
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  • Natasja Staehr Gudmann, Rheumatology Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.
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  • Anne Friesgaard Christensen, l Department of Rheumatology , Vejle Hospital , Vejle , Denmark.
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  • Leif Ejstrup, Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark.
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  • Grith Lykke Sorensen, Institute of Molecular Medicine, University of Southern Denmark, Odense
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  • Anne Gitte Loft
  • Anne C Bay-Jensen, Rheumatology Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.
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  • Anne Sofie Siebuhr, Rheumatology Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.
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  • Peter Junker, Department of Rheumatology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.

The aim of the study was to assess the possible association between type II collagen turnover seromarkers and disease profile in patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). Outpatients with axial SpA (n = 110) or PsA (n = 101) underwent clinical examination including disease activity measures and HLA-B27 typing. The procollagen IIA N-terminal peptide (PIIANP) and a matrix metalloproteinase-generated type II collagen fragment (C2M) were quantified in serum by ELISA. C2M was higher in SpA than in controls, 0.41 versus 0.36 ng/ml (p = 0.004), while PIIANP did not differ between patients and healthy subjects, 2252 versus 2142 ng/ml (p = 0.13). However, DMARD-naïve SpA patients had higher PIIANP, 2461 ng/ml (p = 0.01) and C2M, 0.44 ng/ml (p = 0.0007) levels than controls, and PIIANP correlated with CRP (ρ = 0.34). C2M was lower in SpA smokers, 0.36 ng/ml versus non-smokers, 0.43 ng/ml (p = 0.02), while PIIANP was higher in HLA-B27 positive, 2312 ng/ml versus negative patients, 2021 ng/ml (p = 0.03). In PsA, PIIANP and C2M did not differ between patients and controls, but PIIANP was elevated in patients not receiving DMARDs, 2726 ng/ml. In PsA, PIIANP and C2M did not differ according to smoking and HLA-B27. Cartilage degradation assessed by C2M is increased in SpA irrespective of treatment but not in PsA. Cartilage synthesis reflected by PIIANP is increased in untreated SpA and PsA. PIIANP correlates with CRP in SpA while not in PsA. In DMARD-naïve SpA but not in PsA, HLA-B27 positivity and smoking are associated with a chondro-proliferative metabolic pattern.

Original languageEnglish
JournalRheumatology International
Volume36
Issue4
Pages (from-to)541-9
Number of pages9
ISSN0172-8172
DOIs
Publication statusPublished - Apr 2016
Externally publishedYes

    Research areas

  • Adolescent, Adult, Arthritis, Psoriatic/blood, Biomarkers/blood, Cartilage/diagnostic imaging, Case-Control Studies, Collagen Type II/blood, Cross-Sectional Studies, Denmark/epidemiology, Enzyme-Linked Immunosorbent Assay, Female, HLA-B27 Antigen/immunology, Humans, Male, Middle Aged, Peptide Fragments/blood, Phenotype, Predictive Value of Tests, Procollagen/blood, Risk Factors, Severity of Illness Index, Smoking/adverse effects, Spondylarthritis/blood, Young Adult

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