Anja P. Einholm

  1. 2017
  2. Published

    Arginine replacement of Cys932 converts Na,K-ATPase to an electroneutral pump. / Jensen, Rikke Holm; Khandelwal, Jaanki; Einholm, Anja P.; Andersen, Jens Peter; Artigas, Pablo; Vilsen, Bente.

    2017. Poster session presented at The 15th International Conference on Na,K-ATPase and related transport ATPases, Japan.

    Research output: Contribution to conferencePosterResearch

  3. Published
  4. Published

    Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase. / Holm, Rikke ; Khandelwal, J; Einholm, Anja P.; Andersen, Jens Peter; Artigas, Pablo; Vilsen, Bente.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 2, 10.01.2017, p. 316-321.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. 2016
  6. Published

    Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function. / Holm, Rikke ; Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Andersen, Jens Peter; Vilsen, Bente.

    In: B B A - Bioenergetics, Vol. 1857, No. 11, 11.2016, p. 1807–1828.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  7. Published

    Importance of a potential protein kinase A phosphorylation site of Na+,K+-ATPase and its interaction network for Na+ binding. / Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 291, No. 20, 13.05.2016, p. 10934-47.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published
  9. 2015
  10. Published
  11. Published

    Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314. / Holm, Rikke; Einholm, Anja P; Andersen, Jens P; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 290, No. 15, 10.04.2015, p. 9801-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. 2014
  13. Published

    Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Nielsen, Hang Nguyen; Holm, Rikke; Sobrido, Maria-Jesus; Andersen, Jens Peter; Clausen, Torben; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  14. Published

    Rescue of Na+ and H+ binding in Na+,K+-ATPase M8 aspartate mutants by secondary mutation. / Holm, Rikke; Einholm, Anja P.; Andersen, Jens Peter; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  15. Published

    Distinct neurological disorders with ATP1A3 mutations. / Heinzen, Erin L; Arzimanoglou, Alexis; Brashear, Allison; Clapcote, Steven J; Gurrieri, Fiorella; Goldstein, David B; Jóhannesson, Sigurður H; Mikati, Mohamad A; Neville, Brian; Nicole, Sophie; Ozelius, Laurie J; Poulsen, Hanne; Schyns, Tsveta; Sweadner, Kathleen J; van den Maagdenberg, Arn; Vilsen, Bente; for the ATP1A3 Working Group: .

    In: Lancet Neurology, Vol. 13, No. 5, 05.2014, p. 503-514.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien; Nielsen, Hang Nguyen; Holm, Rikke; Sobrido, María-Jesús; Andersen, Jens Peter; Clausen, Torben; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 289(6), 07.02.2014, p. 3186-3197.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Consequences of mutation to Gln923 for Na+ and K+ binding in Na+/K+-ATPase. / Nielsen, Hang Nguyen; Einholm, Anja P.; Vilsen, Bente.

    2014. Poster session presented at 14th International Conference Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  18. Published

    Elucidation of the functional role of a potential PKA site in Na+,K+-ATPase: Importance of Ser938 in binding of intracellular Na+. / Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Toustrup-Jensen, Mads Schak; Vilsen, Bente.

    2014. Poster session presented at 14th International Conference Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  19. Published

    Importance of Residues Outside the Cation Binding Pocket for Na+ and K+ Binding to the Na+/K+-ATPase. / Christiansen, Line; Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Vilsen, Bente.

    2014. Poster session presented at 14th International ATPase Conference “Na,K‐ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease”, Lunteren, Netherlands.

    Research output: Contribution to conferencePosterResearch

  20. 2013
  21. Published

    Molecular Cloning and Characterization of Porcine Na+/K+-ATPase Isoforms α1, α2, α3 and the ATP1A3 Promoter. / Henriksen, Carina; Kjaer-Sorensen, Kasper; Einholm, Anja Pernille; Madsen, Lone Bruhn; Momeni, Jamal; Bendixen, Christian; Oxvig, Claus; Vilsen, Bente; Larsen, Knud .

    In: P L o S One, Vol. 8, No. 11, e79127, 13.11.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. 2012
  23. Published

    Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion. / Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2012. Poster session presented at 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  24. Published
  25. Published
  26. 2011
  27. Published

    Na+,K+-ATPase amino acids involved in transport of the 3rd sodium ion. / Holm, Rikke; Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  28. Published

    The rapid-onset dystonia parkinsonism mutation D923N of the Na+,K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site and leads to a rise in intracellular Na+ in cell cultur. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  29. Published

    Two neurological disease mutations in the C-terminus of the Na+,K+-ATPase change the intracellular Na+ and K+ content in transfected mammalian COS-1 cell lines. / Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Nielsen, Hang Nguyen; Holm, Rikke; Clausen, Torben; Vilsen, Bente.

    2011. Poster session presented at 13th international ATPase conference Na,K-ATPase and related ATPases, Asilomar, Pacific Grove, CA, United States.

    Research output: Contribution to conferencePosterResearch

  30. 2010
  31. Published

    The rapid-onset dystonia Parkinsonism mutation D923N of the Na+,K+-ATPase alpha-3 isoform disrupts Na+interaction at the third Na+ site. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 285, No. 34, 20.08.2010, p. 26245-26254.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. 2009
  33. Published

    A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism. / Blanco-Arias, Patricia; Einholm, Anja P.; Mamsa, Hafsa; Concheiro, Carla; Gutiérrez-de-Terán, Hugo; Romero, Jesús; Toustrup-Jensen, Mads Schak; Carracedo, Ángel; Jen, Joanna; Vilsen, Bente; Sobrido, María-Jesús.

    In: Human Molecular Genetics, Vol. 18, No. 13, 2009, p. 2370-2377.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. Published

    A new RDP mutation of ATP1A3 with an in-frame insertion of a tyrosine at the very C-terminus of the protein provides further evidence for a key regulatory role of the C-terminal tail of Na+,K+-ATPase. / Einholm, Anja P.; Toustrup-Jensen, Mads Schak; Holm, Rikke; Blanco-Arias, Patricia; Mamsa, Hafsa; Concheiro, Carla; Gutiérrez-Terán, Hugo; Romero, Jesús; Carracedo, Ángel; Jen, Joanna; Sorbrido, María-Jesús; Vilsen, Bente.

    2009. Poster session presented at 2nd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy.

    Research output: Contribution to conferencePosterResearch

  35. Published

    The C Terminus of Na+,K+-ATPase Controls Na+ Affinity on Both Sides of the Membrane through Arg935. / Toustrup-Jensen, Mads Schak; Holm, Rikke; Einholm, Anja P.; Schack, Vivien Rodacker; Morth, Jens Preben; Nissen, Poul; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 284, No. 28, 2009, p. 18715-18725.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. 2008
  37. Published

    Importance of Ser938 for Na+ binding to Na+,K+-ATPase. / Einholm, Anja P.; Jensen, Rikke Holm; Toustrup-Jensen, Mads Schak; Andersen, Jens Peter; Vilsen, Bente.

    2008. Poster session presented at 12th International ATPase Conference: Na,K-ATPase and Related Transport ATPases of P-type: Structures, Mechanisms, and Roles in Health and Disease., Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  38. 2007
  39. Published

    Importance of Leu99 in transmembrane segment M1 of the Na+, K+ -ATPase in the binding and occlusion of K+. / Einholm, Anja P.; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Biological Chemistry, Vol. 282, No. 33, 2007, p. 23854-23866.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Mutational analysis of structure-function relationship of transmembrane segment M1 of the Ca2+-ATPase and the Na+,K+-ATPase. / Einholm, Anja P.

    Faculty of Health Sciences, University of Aarhus, 2007. 152 p.

    Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  41. Published

    Roles of transmembrane segment M1 of Na(+),K (+)-ATPase and Ca (2+)-ATPase, the gatekeeper and the pivot. / Einholm, Anja P.; Andersen, Jens Peter; Vilsen, Bente.

    In: Journal of Bioenergetics and Biomembranes, Vol. 39, No. 5-6, 2007, p. 357-366.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  42. 2005
  43. Published

    Mutation of Gly-94 in transmembrane segment M1 of Na+, K+-ATPase interferes with Na+ and K+ binding in E2P conformation. / Einholm, Anja P.; Jensen, Mads Toustrup; Andersen, Jens Peter; Vilsen, Bente.

    In: Proceedings of the National Academy of Science, USA, Vol. 102, 2005, p. 11254-11259.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. 2004
  45. Published

    Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca2+-ATPase assists in catalysis of E2/E2P partial reactions. / Clausen, J.D.; Vilsen, B.; McIntosh, D.B.; Einholm, A.P.; Andersen, J.P.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, 2004, p. 2776-2781.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    Importance of transmembrane segment M1 of the sarcoplasmic reticulum Ca2+-ATPase in Ca2+ occlusion and phosphoenzyme processing. / Einholm, A.P.; Vilsen, B.; Andersen, J.P.

    In: Journal of Biological Chemistry, Vol. 279, 2004, p. 15888-15896.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. 2003
  48. Published

    Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. / Einholm, Anja P; Pedersen, Katrine E; Wind, Troels; Kulig, Paulina; Overgaard, Michael T; Jensen, Jan K; Bødker, Julie S; Christensen, Anni; Charlton, Peter; Andreasen, Peter A.

    In: Biochemical Journal, Vol. 373, No. Pt 3, 2003, p. 723-32.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    Functional consequences of charge reversals of acidic residues in M1 of the Ca-ATPase. / Einholm, A.P.; Vilsen, B.; Andersen, J.P.

    In: New York Academy of Sciences. Annals, Vol. 986, 2003, p. 310-311.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  50. Published

    Mutagenesis of residues involved in control of the Ca2+ entry pathway and conformational changes associated with Ca2+ binding in the SR Ca2+-ATPase. / Andersen, J.P.; Clausen, J.D.; Einholm, A.P.; Vilsen, B.

    In: New York Academy of Sciences. Annals, Vol. 986, 2003, p. 72-81.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearch

  51. Published

    Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands. / Pedersen, Katrine E; Einholm, Anja P; Christensen, Anni; Schack, Lotte; Wind, Troels; Kenney, John M; Andreasen, Peter A.

    In: Biochemical Journal, Vol. 372, No. Pt 3, 2003, p. 747-55.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. 2001
  53. Published

    A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization. / Egelund, R; Einholm, A P; Pedersen, K E; Nielsen, R W; Christensen, A; Deinum, J; Andreasen, Peter A.

    In: Journal of Biological Chemistry, Vol. 276, No. 16, 2001, p. 13077-86.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. Published

    Structural and functional aspects of plaminogen activator inhibitor-1 neutralisation. / Einholm, Anja P.

    Faculty of Science, University of Aarhus, 2001. 103 p.

    Research output: Book/anthology/dissertation/reportBookResearch