Angela Fago

2024

Assessing metabolic rates in zebrafish using a 3D-printed intermittent-flow respirometer and swim tunnel system

Hejlesen, R., Scheffler, F. B., Byrge, C. G., Kjær-Sørensen, K., Oxvig, C., Fago, A. & Malte, H., Jun 2024, In: Biology Open. 13, 6, 6 p., bio060375.

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Open Access

The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM

Takahashi, K., Lee, Y., Fago, A., Bautista, N. M., Storz, J. F., Kawamoto, A., Kurisu, G., Nishizawa, T. & Tame, J. R. H., 2 Aug 2024, In: Nature Communications. 15, 1, 6505.

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2 Citations (Scopus)

2023

Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin

Natarajan, C., Signore, A. V., M. Bautista, N., Hoffmann, F. G., Tame, J. R. H., Fago, A. & Storz, J. F., Jan 2023, In: Current Biology. 33, 1, p. 98-108.e4

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6 Citations (Scopus)

2 Downloads (Pure)

Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller's sea cows

Signori, A. V., Morrison, P. R., Brauner, C. J., Fago, A., Weber, R. E. & Campbell, K. L., 1 Jun 2023, In: eLife. 12, e85414.

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Open Access

1 Citation (Scopus)

Generation and validation of a myoglobin knockout zebrafish model

Hejlesen, R., Kjær-Sørensen, K., Fago, A. & Oxvig, C., Dec 2023, In: Transgenic Research. 32, 6, p. 537-546 10 p.

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Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts

Bundgaard, A., Gruszczyk, A. V., Prag, H. A., Williams, C., McIntyre, A., Ruhr, I. M., James, A. M., Galli, G. L. J., Murphy, M. P. & Fago, A., May 2023, In: Journal of Experimental Biology. 226, 9, 11 p., jeb245516.

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6 Citations (Scopus)

Structural and oxidative investigation of a recombinant high-yielding fetal hemoglobin mutant

Kettisen, K., Nyblom, M., Smeds, E., Fago, A. & Bülow, L., Mar 2023, In: Frontiers in Molecular Biosciences. 10, 1133985.

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Open Access

2 Citations (Scopus)

2022

Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice

Ivy, C. M., Wearing, O. H., Natarajan, C., Schweizer, R. M., Gutiérrez-Pinto, N., Velotta, J. P., Campbell-Staton, S. C., Petersen, E. E., Fago, A., Cheviron, Z. A., Storz, J. F. & Scott, G. R., Jan 2022, In: Journal of Experimental Biology. 225, 2, 12 p., jeb243595.

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Open Access

7 Citations (Scopus)

New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates

Fago, A., Jul 2022, In: Acta Physiologica (Print). 235, 3, p. e13841 e13841.

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18 Citations (Scopus)

32 Downloads (Pure)

Ontogeny of hemoglobin‑oxygen binding and multiplicity in the obligate air-breathing fish Arapaima gigas

Weber, R. E., Damsgaard, C., Fago, A., Val, A. L. & Moens, L., Jun 2022, In: Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 268, 111190.

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2 Citations (Scopus)

27 Downloads (Pure)

2021

Carbon dioxide and bicarbonate accumulation in caiman erythrocytes during diving

Bautista, N. M., Damsgaard, C., Fago, A. & Wang, T., May 2021, In: Journal of Experimental Biology. 224, 9, 6 p., 242435.

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5 Citations (Scopus)

79 Downloads (Pure)

Changes in hemoglobin function and isoform expression during embryonic development in the American alligator, Alligator mississippiensis

M. Bautista, N., Petersen, E. E., Jensen, R. J., Natarajan, C., Storz, J. F., Crossley, II, D. A. & Fago, A., 2021, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 321, 6, p. R869-R878

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4 Citations (Scopus)

Evolution of hemoglobin function in tropical air-breathing catfishes

Andersen, N. C. M., Fago, A. & Damsgaard, C., Nov 2021, In: Journal of Experimental Zoology. Part A: Ecological and Integrative Physiology . 335, 9-10, p. 814-819 6 p.

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2 Citations (Scopus)

Exploring pathways of NO and H₂S signaling in metabolic depression: The case of anoxic turtles

Bundgaard, A., Jensen, B. S., Jensen, F. B. & Fago, A., Mar 2021, In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 253, 6 p., 110857.

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7 Citations (Scopus)

High temperature impairs mitochondrial function in rainbow trout cardiac mitochondria

Michaelsen, J., Fago, A. & Bundgaard, A., Apr 2021, In: Journal of Experimental Biology. 224, 9, 7 p., jeb242382.

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27 Citations (Scopus)

148 Downloads (Pure)

Intrinsic Mechanisms Underlying Hypoxia-Tolerant Mitochondrial Phenotype During Hypoxia-Reoxygenation Stress in a Marine Facultative Anaerobe, the Blue Mussel Mytilus edulis

Sokolov, E. P., Adzigbli, L., Markert, S., Bundgaard, A., Fago, A., Becher, D., Hirschfeld, C. & Sokolova, I. M., Nov 2021, In: Frontiers in Marine Science. 8, 15 p., 773734.

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Open Access

13 Citations (Scopus)

New insights into the allosteric effects of CO₂ and Bicarbonate on Crocodilian Hemoglobin

Bautista, N. M., Malte, H., Natarajan, C., Wang, T., Storz, J. F. & Fago, A., Aug 2021, In: Journal of Experimental Biology. 224, 15, 242615.

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4 Citations (Scopus)

65 Downloads (Pure)

Sulfide metabolism and the mechanism of torpor

Jensen, B. S. & Fago, A., Sept 2021, In: Journal of Experimental Biology. 224, 17, 215764.

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6 Citations (Scopus)

53 Downloads (Pure)

Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels

Jensen, B. S., Pardue, S., Duffy, B., Kevil, C. G., Staples, J. F. & Fago, A., Jun 2021, In: Free Radical Biology and Medicine. 169, p. 181-186 6 p.

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11 Citations (Scopus)

69 Downloads (Pure)

2020

A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood

Jensen, B. & Fago, A., 2020, In: Antioxidants & Redox Signaling. 32, 4, p. 258-265 8 p.

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18 Citations (Scopus)

Effect of NH₂-terminal acetylation on the oxygenation properties of vertebrate haemoglobin

Natarajan, C., Signore, A. V., Kumar, V., Weber, R. E., Fago, A. & Storz, J. F., Oct 2020, In: The Biochemical journal. 477, 19, p. 3839-3850 12 p.

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5 Citations (Scopus)

Genetic and functional diversity of the multiple lungfish myoglobins

Lüdemann, J., Fago, A., Falke, S., Wisniewsky, M., Schneider, I., Fabrizius, A. & Burmester, T., 2020, In: FEBS journal. 287, 8, p. 1598-1611 14 p.

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6 Citations (Scopus)

36 Downloads (Pure)

Metabolic adaptations to anoxia and reoxygenation: New lessons from freshwater turtles and crucian carp

Bundgaard, A., Ruhr, I. M., Fago, A. & Galli, G. L. J., 2020, In: Current Opinion in Endocrine and Metabolic Research. 11, April, p. 55-64 10 p.

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32 Citations (Scopus)

Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (Boleophthalmus pectinirostris)

Storz, J. F., Natarajan, C., Grouleff, M. K., Vandewege, M., Hoffmann, F. G., You, X., Venkatesh, B. & Fago, A., Jan 2020, In: Journal of Experimental Biology. 223, 2, 9 p., jeb217307.

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Open Access

11 Citations (Scopus)

Stable mitochondrial CICIII2 supercomplex interactions in reptiles versus homeothermic vertebrates

Bundgaard, A., James, A. M., Harbour, M. E., Murphy, M. P. & Fago, A., Jun 2020, In: Journal of Experimental Biology. 223, 12, 9 p., jeb223776.

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17 Citations (Scopus)

Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP, and CO₂

Fago, A., Natarajan, C., Pettinati, M., Hoffmann, F. G., Wang, T., Weber, R. E., Drusin, S. I., Issoglio, F., Martí, M. A., Estrin, D. & Storz, J. F., Mar 2020, In: American journal of physiology. Regulatory, integrative and comparative physiology. 318, 3, p. R657-R667 11 p.

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Open Access

10 Citations (Scopus)

2019

Emergence of a Chimeric Globin Pseudogene and Increased Hemoglobin Oxygen Affinity Underlie the Evolution of Aquatic Specializations in Sirenia

Signore, A. V., Paijmans, J. L. A., Hofreiter, M., Fago, A., Weber, R. E., Springer, M. S. & Campbell, K. L., 2019, In: Molecular Biology and Evolution. 36, 6, p. 1134-1147 14 p.

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2 Citations (Scopus)

81 Downloads (Pure)

Globin E is a myoglobin-related, respiratory protein highly expressed in lungfish oocytes

Lüdemann, J., Verissimo, K. M., Dreger, K., Fago, A., Schneider, I. & Burmester, T., Jan 2019, In: Scientific Reports. 9, 1, 11 p., 280.

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Open Access

11 Citations (Scopus)

Hypoxia enhances blood O ₂ affinity and depresses skeletal muscle O ₂ consumption in zebrafish (Danio rerio)

Cadiz, L., Bundgaard, A., Malte, H. & Fago, A., 2019, In: Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology. 234, p. 18-25 8 p.

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15 Citations (Scopus)

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury

Bundgård, A. M., James, A. M., Gruszczyk, A. V., Martin, J., Murphy, M. P. & Fago, A., Feb 2019, In: Scientific Reports. 9, 1, 10 p., 2850.

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Open Access

58 Citations (Scopus)

The Zebrafish Cytochrome b(5)/Cytochrome b(5) Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b(5)/Cytochrome b(5) Reductases during Vertebrate Evolution

Amdahl, M. B., Petersen, E. E., Bocian, K., Kaliszuk, S. J., DeMartino, A. W., Tiwari, S., Sparacino-Watkins, C. E., Corti, P., Rose, J. J., Gladwin, M. T., Fago, A. & Tejero, J., 1 Jul 2019, In: Biochemistry. 58, 29, p. 3212-3223 12 p.

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15 Citations (Scopus)

Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles

Jensen, B., Pardue, S., Kevil, C. G. & Fago, A., Jun 2019, In: Journal of Experimental Biology. 222, 12, jeb203976.

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5 Citations (Scopus)

95 Downloads (Pure)

Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

Bundgaard, A., Qvortrup, K., Rasmussen, L. J. & Fago, A., 10 Jun 2019, In: Journal of Experimental Biology. 222, 11, 9 p., jeb200410.

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30 Citations (Scopus)

128 Downloads (Pure)

2018

Allosteric mechanisms underlying the adaptive increase in hemoglobin-oxygen affinity of the bar-headed goose

Jendroszek, A., Malte, H., Overgaard, C. B., Beedholm, K., Natarajan, C., Weber, R. E., Storz, J. F. & Fago, A., Sept 2018, In: Journal of Experimental Biology. 221, 18, 10 p., 185470.

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29 Citations (Scopus)

121 Downloads (Pure)

Ancestral protein resurrection reveals mutational pathways and functional mechanisms of hemoglobin adaption

Storz, J. F., Natarajan, C., Signore, A. V., Hoffmann, F. G., Tame, J. R. H., Weber, R. E. & Fago, A., 2018, p. Session 5.

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392 Downloads (Pure)

Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau

Zhu, X., Guan, Y., Signore, A. V., Natarajan, C., DuBay, S. G., Cheng, Y., Han, N., Song, G., Qu, Y., Moriyama, H., Hoffmann, F. G., Fago, A., Lei, F. & Storz, J. F., 20 Feb 2018, In: Proceedings of the National Academy of Sciences (PNAS). 115, 8, p. 1865-1870 6 p.

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73 Citations (Scopus)

Functional diversification of sea lamprey globins in evolution and development

Fago, A., Rohlfing, K., Petersen, E. E., Jendroszek, A. & Burmester, T., Feb 2018, In: B B A - Proteins and Proteomics. 1866, 2, p. 283-291 9 p.

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10 Citations (Scopus)

Hemoglobin polymerization via disulfide bond formation in the hypoxia-tolerant turtle Trachemys scripta: implications for antioxidant defense and O-2 transport

Petersen, A. G., Petersen, S. V., Frische, S., Drakulic, S., Golas, M. M., Sander, B. & Fago, A., Jan 2018, In: A J P: Regulatory, Integrative and Comparative Physiology (Online). 314, 1, p. R84-R93 10 p.

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9 Citations (Scopus)

Investigating the molecular basis of a unique mode of allosteric regulatory control: bicarbonate sensitivity of crocodilian hemoglobin

Natarajan, C., Hoffmann, F. G., Signore, A. V., Weber, R. E., Fago, A. & Storz, J., 2018, p. P27.

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317 Downloads (Pure)

Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose

Natarajan, C., Jendroszek, A., Kumar, A., Weber, R. E., Tame, J. R. H., Fago, A. & Storz, J. F., Apr 2018, In: P L o S Genetics. 14, 4, 19 p., e1007331.

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56 Citations (Scopus)

380 Downloads (Pure)

Reactions of ferric hemoglobin and myoglobin with hydrogen sulfide under physiological conditions

Jensen, B. & Fago, A., 1 May 2018, In: Journal of Inorganic Biochemistry. 182, p. 133-140 8 p.

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55 Citations (Scopus)

Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex I S-nitrosation

Bundgaard, A., James, A. M., Joyce, W., Murphy, M. P. & Fago, A., Apr 2018, In: Journal of Experimental Biology. 221, 8, 10 p., 174391.

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41 Citations (Scopus)

198 Downloads (Pure)

The 2018 lake louise acute mountain sickness score

Roach, R. C., Hackett, P. H., Oelz, O., Bärtsch, P., Luks, A. M., Macinnis, M. J., Baillie, J. K. & Lake Louise AMS Score Consensus Committee, 1 Mar 2018, In: High Altitude Medicine and Biology. 19, 1, p. 4-6 3 p.

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Open Access

369 Citations (Scopus)

2017

A comparison of blood nitric oxide metabolites and hemoglobin functional properties among diving mammals

Fago, A., Parraga, D. G., Petersen, E. E., Kristensen, N., Giouri, L. & Jensen, F. B., 1 Mar 2017, In: Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 205, p. 35-40 6 p.

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13 Citations (Scopus)

Functional characterization of hemoglobin isoforms from high and low altitude geese species. SEB 2017 Conference, Gothenburg, Sweden

Jendroszek, A., Malte, H., Weber, R. E., Storz, J. F. & Fago, A., 2017, p. 249. 1 p.

Research output: Contribution to conference › Poster › Research

Functional roles of globin proteins in hypoxia-tolerant ectothermic vertebrates

Fago, A., Oct 2017, In: Journal of Applied Physiology. 123, 4, p. 926-934 9 p.

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16 Citations (Scopus)

Interactions of zebrafish Cytoglobins with oxygen and nitric oxide

Amdahl, M. B., Petersen, E., Corti, P., Sparacino-Watkins, C., Fago, A., Gladwin, M. T. & Tejero, J., Nov 2017, In: Free Radical Biology & Medicine. 112, Supplement 1, p. 19-19 1 p.

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O₂ binding and CO₂ sensitivity in haemoglobins of subterranean African mole rats

Weber, R. E., Jarvis, J. U. M., Fago, A. & Bennett, N. C., 1 Nov 2017, In: Journal of Experimental Biology. 220, 21, p. 3939-3948 10 p.

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Open Access

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18 Citations (Scopus)

154 Downloads (Pure)

Oryx leucoryx hemoglobin subunit alpha (HBA) gene, complete cds. GenBank Accession No. MF688769.

Andreasen, J. (Producer), Fago, A. (Producer), Larsen, K. E. (Producer) & Thomsen, B. (Producer), 2017

Research output: Non-textual form › Dataset › Research › peer-review

Oryx leucoryx hemoglobin subunit beta (HBB) gene, complete cds. GenBank Accession No.MG594287.

Andreasen, J. (Producer), Fago, A. (Producer), Larsen, K. E. (Producer) & Thomsen, B. (Producer), 2017

Research output: Non-textual form › Dataset › Research › peer-review

Angela Fago

Research output

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