Projects per year
Personal profile
Research
My research interest is to understand molecular mechanisms underlying hypoxia tolerance in animals, particularly in vertebrate species able to cope with little or no oxygen in the environment. We integrate classic whole animal physiology, biochemistry and molecular biology to unravel how processes related to oxygen transport and oxygen consumption are regulated at the biochemical and mitochondrial level, including the effect of gaseous signaling molecules H2S, NO and CO2. By studying how animals respond to oxygen limitations in the environment, we provide fundamental mechanistic knowledge to better understand human mitochondrial disfunction and ischemia/reperfusion injury from stroke and heart attack.
Keywords
- Animal physiology
- blood,
- oxygen transport, respiration
- gasotransmitters
- Animal adaptation to the environment
- hypoxia,
- hibernation, metabolic depression
- mitochondria
- Molecular ecophysiology
- protein function,
- globin proteins
Areas of expertise
- animal physiology
- mitochondrial function
- oxygen transport and respiration
- hypoxia
- biochemistry and metabolism
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CO2 as a metabolic signaling molecule
Fago, A. (PI), Palmfeldt, J. (Participant), Bundgård, A. M. (Participant) & Bross, P. (Participant)
01/04/2024 → 31/12/2027
Project: Research
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The importance of myoglobin for mitochondrial function in vivo
Fago, A. (PI), Oxvig, C. (Collaborator), Bakkeren, C. (Participant) & Lefevre, S. (Collaborator)
01/08/2023 → 30/11/2026
Project: Research
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Assessing the role of myoglobin in sulfide signaling by means of genetically modified zebrafish
Fago, A. (PI), Oxvig, C. (CoPI), Hejlesen, R. (Participant), Kjær-Sørensen, K. (Participant) & Jensen, B. S. (PI)
01/08/2020 → 30/06/2025
Project: Research
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Mitochondrial adaptations to environmental change
Fago, A. (PI), Overgaard, J. (CoPI) & Wang, T. (Participant)
01/01/2021 → 31/12/2023
Project: Research
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Hydrogen sulfide signalling and transport in vertebrates
Fago, A. (PI), Bundgård, A. M. (Participant) & Jensen, B. S. (Participant)
01/01/2017 → 01/01/2020
Project: Research
Research output
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Assessing metabolic rates in zebrafish using a 3D-printed intermittent-flow respirometer and swim tunnel system
Hejlesen, R., Scheffler, F. B., Byrge, C. G., Kjær-Sørensen, K., Oxvig, C., Fago, A. & Malte, H., Jun 2024, In: Biology Open. 13, 6, 6 p., bio060375.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM
Takahashi, K., Lee, Y., Fago, A., Bautista, N. M., Storz, J. F., Kawamoto, A., Kurisu, G., Nishizawa, T. & Tame, J. R. H., 2 Aug 2024, In: Nature Communications. 15, 1, 6505.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access4 Citations (Scopus) -
Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin
Natarajan, C., Signore, A. V., M. Bautista, N., Hoffmann, F. G., Tame, J. R. H., Fago, A. & Storz, J. F., Jan 2023, In: Current Biology. 33, 1, p. 98-108.e4Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)8 Downloads (Pure) -
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller's sea cows
Signori, A. V., Morrison, P. R., Brauner, C. J., Fago, A., Weber, R. E. & Campbell, K. L., 1 Jun 2023, In: eLife. 12, e85414.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
Generation and validation of a myoglobin knockout zebrafish model
Hejlesen, R., Kjær-Sørensen, K., Fago, A. & Oxvig, C., Dec 2023, In: Transgenic Research. 32, 6, p. 537-546 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile3 Downloads (Pure)
Activities
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Sulfide metabolism and the mechanism of torpor
Fago, A. (Lecturer)
2023Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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How vertebrates regulate oxygen transport and consumption to survive oxygen lack
Fago, A. (Lecturer)
2022Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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Suppression of mitochondrial respiration by H2S in hibernating 13-lined ground squirrels
Fago, A. (Lecturer)
2021Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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International Mini-symposium on Mitochondrial and Metabolic Responses to Low Oxygen
Fago, A. (Organizer)
2019Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
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APS Intersociety meeting in Comparative Physiology
Fago, A. (Speaker)
2018Activity: Participating in or organising an event types › Participation in or organisation af a conference
Prizes
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Skou-stipendium (FNU). Defense against oxidative stress. The role of globin proteins.
Fago, Angela (Recipient), 1 Sept 2006
Prize: Prizes, scholarships, distinctions