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Andreas Roepstorff

Socially Learned Attitude Change is Not Reduced In Medicated Patients with Schizophrenia

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Socially Learned Attitude Change is Not Reduced In Medicated Patients with Schizophrenia. / Simonsen, Arndis; Fusaroli, Riccardo; Skewes, Joshua Charles; Roepstorff, Andreas; Mors, Ole; Bliksted, Vibeke Fuglsang; Campbell-Meiklejohn, Daniel.

In: Scientific Reports, Vol. 9, 992, 2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{be7c4151e5294ca4bbc750f1efc1634c,
title = "Socially Learned Attitude Change is Not Reduced In Medicated Patients with Schizophrenia",
abstract = "Schizophrenia is often associated with distinctive or odd social behaviours. Previous work suggests this could be due to a general reduction in conformity; however, this work only assessed the tendency to publicly agree with others, which may involve a number of different mechanisms. In this study, we specifically investigated whether patients display a reduced tendency to adopt other people{\textquoteright}s opinions (socially learned attitude change). We administered a computerized conformity task, assumed to rely on reinforcement learning circuits, to 32 patients with schizophrenia or schizo-affective disorder and 39 matched controls. Each participant rated 153 faces for trustworthiness. After each rating, they were immediately shown the opinion of a group. After approximately 1 hour, participants were unexpectedly asked to rate all the faces again. We compared the degree of attitude change towards group opinion in patients and controls. Patients presented equal or more social influence on attitudes than controls. This effect may have been medication induced, as increased conformity was seen with higher antipsychotic dose. The results suggest that there is not a general decline in conformity in medicated patients with schizophrenia and that previous findings of reduced conformity are likely related to mechanisms other than reinforcement based social influence on attitudes.",
keywords = "ANTIPSYCHOTIC-DRUGS, CONFORMITY, DOPAMINE, FEEDBACK, IN-GROUP, INDEPENDENCE, METAANALYSIS, MODULATION, OXYTOCIN, RECEPTOR",
author = "Arndis Simonsen and Riccardo Fusaroli and Skewes, {Joshua Charles} and Andreas Roepstorff and Ole Mors and Bliksted, {Vibeke Fuglsang} and Daniel Campbell-Meiklejohn",
year = "2019",
doi = "10.1038/s41598-018-37250-x",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Socially Learned Attitude Change is Not Reduced In Medicated Patients with Schizophrenia

AU - Simonsen, Arndis

AU - Fusaroli, Riccardo

AU - Skewes, Joshua Charles

AU - Roepstorff, Andreas

AU - Mors, Ole

AU - Bliksted, Vibeke Fuglsang

AU - Campbell-Meiklejohn, Daniel

PY - 2019

Y1 - 2019

N2 - Schizophrenia is often associated with distinctive or odd social behaviours. Previous work suggests this could be due to a general reduction in conformity; however, this work only assessed the tendency to publicly agree with others, which may involve a number of different mechanisms. In this study, we specifically investigated whether patients display a reduced tendency to adopt other people’s opinions (socially learned attitude change). We administered a computerized conformity task, assumed to rely on reinforcement learning circuits, to 32 patients with schizophrenia or schizo-affective disorder and 39 matched controls. Each participant rated 153 faces for trustworthiness. After each rating, they were immediately shown the opinion of a group. After approximately 1 hour, participants were unexpectedly asked to rate all the faces again. We compared the degree of attitude change towards group opinion in patients and controls. Patients presented equal or more social influence on attitudes than controls. This effect may have been medication induced, as increased conformity was seen with higher antipsychotic dose. The results suggest that there is not a general decline in conformity in medicated patients with schizophrenia and that previous findings of reduced conformity are likely related to mechanisms other than reinforcement based social influence on attitudes.

AB - Schizophrenia is often associated with distinctive or odd social behaviours. Previous work suggests this could be due to a general reduction in conformity; however, this work only assessed the tendency to publicly agree with others, which may involve a number of different mechanisms. In this study, we specifically investigated whether patients display a reduced tendency to adopt other people’s opinions (socially learned attitude change). We administered a computerized conformity task, assumed to rely on reinforcement learning circuits, to 32 patients with schizophrenia or schizo-affective disorder and 39 matched controls. Each participant rated 153 faces for trustworthiness. After each rating, they were immediately shown the opinion of a group. After approximately 1 hour, participants were unexpectedly asked to rate all the faces again. We compared the degree of attitude change towards group opinion in patients and controls. Patients presented equal or more social influence on attitudes than controls. This effect may have been medication induced, as increased conformity was seen with higher antipsychotic dose. The results suggest that there is not a general decline in conformity in medicated patients with schizophrenia and that previous findings of reduced conformity are likely related to mechanisms other than reinforcement based social influence on attitudes.

KW - ANTIPSYCHOTIC-DRUGS

KW - CONFORMITY

KW - DOPAMINE

KW - FEEDBACK

KW - IN-GROUP

KW - INDEPENDENCE

KW - METAANALYSIS

KW - MODULATION

KW - OXYTOCIN

KW - RECEPTOR

UR - http://www.scopus.com/inward/record.url?scp=85060942246&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-37250-x

DO - 10.1038/s41598-018-37250-x

M3 - Journal article

C2 - 30700729

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 992

ER -