Andreas Roepstorff

Serotoninergic effects on judgments and social learning of trustworthiness

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Serotoninergic effects on judgments and social learning of trustworthiness. / Simonsen, Arndis; Scheel-Krüger, Jørgen; Jensen, Mads; Roepstorff, Andreas; Møller, Arne; Frith, Chris D; Campbell-Meiklejohn, Daniel.

In: Psychopharmacology, 25.01.2014.

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@article{646dc4d94ea445e3960ee60af25506dd,
title = "Serotoninergic effects on judgments and social learning of trustworthiness",
abstract = "RationaleCertain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as reduced apparent trustworthiness of others. Trustworthiness judgments can emerge from either direct observation or references provided by third parties.ObjectiveWe assessed whether explicit judgments of trustworthiness and social influences on those judgments are altered by changes within serotonergic systems.MethodsWe implemented a double-blind between-subject design where 20 healthy female volunteers received a single dose of the selective serotonin reuptake inhibitor (SSRI) citalopram (2 × 20 mg), while 20 control subjects (matched on age, intelligence, and years of education) received a placebo. Subjects performed a face-rating task assessing how trustworthy they found 153 unfamiliar others (targets). After each rating, the subjects were told how other subjects, on average, rated the same target. The subjects then performed 30 min of distractor tasks before, unexpectedly, being asked to rate all 153 faces again, in a random order.ResultsCompared to subjects receiving a placebo, subjects receiving citalopram rated targets as less trustworthy. They also conformed more to opinions of others, when others rated targets to be even less trustworthy than subjects had initially indicated. The two effects were independent of negative effects of citalopram on subjective state.ConclusionsThis is evidence that serotonin systems can mediate explicit assessment and social learning of the trustworthiness of others.",
author = "Arndis Simonsen and J{\o}rgen Scheel-Kr{\"u}ger and Mads Jensen and Andreas Roepstorff and Arne M{\o}ller and Frith, {Chris D} and Daniel Campbell-Meiklejohn",
year = "2014",
month = jan,
day = "25",
doi = "10.1007/s00213-014-3444-2",
language = "English",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Serotoninergic effects on judgments and social learning of trustworthiness

AU - Simonsen, Arndis

AU - Scheel-Krüger, Jørgen

AU - Jensen, Mads

AU - Roepstorff, Andreas

AU - Møller, Arne

AU - Frith, Chris D

AU - Campbell-Meiklejohn, Daniel

PY - 2014/1/25

Y1 - 2014/1/25

N2 - RationaleCertain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as reduced apparent trustworthiness of others. Trustworthiness judgments can emerge from either direct observation or references provided by third parties.ObjectiveWe assessed whether explicit judgments of trustworthiness and social influences on those judgments are altered by changes within serotonergic systems.MethodsWe implemented a double-blind between-subject design where 20 healthy female volunteers received a single dose of the selective serotonin reuptake inhibitor (SSRI) citalopram (2 × 20 mg), while 20 control subjects (matched on age, intelligence, and years of education) received a placebo. Subjects performed a face-rating task assessing how trustworthy they found 153 unfamiliar others (targets). After each rating, the subjects were told how other subjects, on average, rated the same target. The subjects then performed 30 min of distractor tasks before, unexpectedly, being asked to rate all 153 faces again, in a random order.ResultsCompared to subjects receiving a placebo, subjects receiving citalopram rated targets as less trustworthy. They also conformed more to opinions of others, when others rated targets to be even less trustworthy than subjects had initially indicated. The two effects were independent of negative effects of citalopram on subjective state.ConclusionsThis is evidence that serotonin systems can mediate explicit assessment and social learning of the trustworthiness of others.

AB - RationaleCertain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as reduced apparent trustworthiness of others. Trustworthiness judgments can emerge from either direct observation or references provided by third parties.ObjectiveWe assessed whether explicit judgments of trustworthiness and social influences on those judgments are altered by changes within serotonergic systems.MethodsWe implemented a double-blind between-subject design where 20 healthy female volunteers received a single dose of the selective serotonin reuptake inhibitor (SSRI) citalopram (2 × 20 mg), while 20 control subjects (matched on age, intelligence, and years of education) received a placebo. Subjects performed a face-rating task assessing how trustworthy they found 153 unfamiliar others (targets). After each rating, the subjects were told how other subjects, on average, rated the same target. The subjects then performed 30 min of distractor tasks before, unexpectedly, being asked to rate all 153 faces again, in a random order.ResultsCompared to subjects receiving a placebo, subjects receiving citalopram rated targets as less trustworthy. They also conformed more to opinions of others, when others rated targets to be even less trustworthy than subjects had initially indicated. The two effects were independent of negative effects of citalopram on subjective state.ConclusionsThis is evidence that serotonin systems can mediate explicit assessment and social learning of the trustworthiness of others.

U2 - 10.1007/s00213-014-3444-2

DO - 10.1007/s00213-014-3444-2

M3 - Journal article

C2 - 24464530

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

ER -