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Anders Hammerich Riis

Statin use and risk of amyotrophic lateral sclerosis and other motor neuron disorders

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Statin use and risk of amyotrophic lateral sclerosis and other motor neuron disorders. / Sørensen, Henrik Toft; Riis, Anders; Lash, Timothy L; Pedersen, Lars.

In: Circulation: Cardiovascular Quality and Outcomes, Vol. 3, No. 4, 2010, p. 413-7.

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@article{f97b15b0f24611dfa891000ea68e967b,
title = "Statin use and risk of amyotrophic lateral sclerosis and other motor neuron disorders",
abstract = "BACKGROUND: Use of statins has been associated with an amyotrophic lateral sclerosis-like syndrome in 2 analyses of overlapping surveillance databases that record adverse events potentially related to prescription drug use. We assessed whether statin use is associated with the occurrence of amyotrophic lateral sclerosis and other motor neuron disorders. METHODS AND RESULTS: We conducted a population-based case-control study in Northern Denmark, with a population of 1.8 million. From the Danish National Registry of Patients, we identified incident cases coded with amyotrophic lateral sclerosis or other motor neuron syndromes during the period from 1999 to 2008. We selected 10 population control subjects matched to cases on sex, birth year, and calendar time. Statin use was ascertained in the prescription database in the region--and so recorded before diagnosis--and associated with disease occurrence by conditional logistic regression adjusting for covariates. We identified 556 cases of amyotrophic lateral sclerosis or other motor neuron syndromes and 5560 population control subjects. The odds ratio associating disease occurrence with statin use was 0.96 (95% confidence interval, 0.73 to 1.28). Recent users of statins, former users, and users of short or long duration had similarly near-null associations. CONCLUSIONS: Any risk of amyotrophic lateral sclerosis associated with statin use probably is small, so outweighed by the important clinical advantages of statin medications to prevent and treat cardiovascular diseases.",
author = "S{\o}rensen, {Henrik Toft} and Anders Riis and Lash, {Timothy L} and Lars Pedersen",
year = "2010",
doi = "10.1161/CIRCOUTCOMES.110.936278",
language = "English",
volume = "3",
pages = "413--7",
journal = "Circulation: Cardiovascular Quality and Outcomes",
issn = "1941-7705",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "4",

}

RIS

TY - JOUR

T1 - Statin use and risk of amyotrophic lateral sclerosis and other motor neuron disorders

AU - Sørensen, Henrik Toft

AU - Riis, Anders

AU - Lash, Timothy L

AU - Pedersen, Lars

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Use of statins has been associated with an amyotrophic lateral sclerosis-like syndrome in 2 analyses of overlapping surveillance databases that record adverse events potentially related to prescription drug use. We assessed whether statin use is associated with the occurrence of amyotrophic lateral sclerosis and other motor neuron disorders. METHODS AND RESULTS: We conducted a population-based case-control study in Northern Denmark, with a population of 1.8 million. From the Danish National Registry of Patients, we identified incident cases coded with amyotrophic lateral sclerosis or other motor neuron syndromes during the period from 1999 to 2008. We selected 10 population control subjects matched to cases on sex, birth year, and calendar time. Statin use was ascertained in the prescription database in the region--and so recorded before diagnosis--and associated with disease occurrence by conditional logistic regression adjusting for covariates. We identified 556 cases of amyotrophic lateral sclerosis or other motor neuron syndromes and 5560 population control subjects. The odds ratio associating disease occurrence with statin use was 0.96 (95% confidence interval, 0.73 to 1.28). Recent users of statins, former users, and users of short or long duration had similarly near-null associations. CONCLUSIONS: Any risk of amyotrophic lateral sclerosis associated with statin use probably is small, so outweighed by the important clinical advantages of statin medications to prevent and treat cardiovascular diseases.

AB - BACKGROUND: Use of statins has been associated with an amyotrophic lateral sclerosis-like syndrome in 2 analyses of overlapping surveillance databases that record adverse events potentially related to prescription drug use. We assessed whether statin use is associated with the occurrence of amyotrophic lateral sclerosis and other motor neuron disorders. METHODS AND RESULTS: We conducted a population-based case-control study in Northern Denmark, with a population of 1.8 million. From the Danish National Registry of Patients, we identified incident cases coded with amyotrophic lateral sclerosis or other motor neuron syndromes during the period from 1999 to 2008. We selected 10 population control subjects matched to cases on sex, birth year, and calendar time. Statin use was ascertained in the prescription database in the region--and so recorded before diagnosis--and associated with disease occurrence by conditional logistic regression adjusting for covariates. We identified 556 cases of amyotrophic lateral sclerosis or other motor neuron syndromes and 5560 population control subjects. The odds ratio associating disease occurrence with statin use was 0.96 (95% confidence interval, 0.73 to 1.28). Recent users of statins, former users, and users of short or long duration had similarly near-null associations. CONCLUSIONS: Any risk of amyotrophic lateral sclerosis associated with statin use probably is small, so outweighed by the important clinical advantages of statin medications to prevent and treat cardiovascular diseases.

U2 - 10.1161/CIRCOUTCOMES.110.936278

DO - 10.1161/CIRCOUTCOMES.110.936278

M3 - Journal article

C2 - 20530788

VL - 3

SP - 413

EP - 417

JO - Circulation: Cardiovascular Quality and Outcomes

JF - Circulation: Cardiovascular Quality and Outcomes

SN - 1941-7705

IS - 4

ER -