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Anders Hammerich Riis

Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry

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Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry. / Pedersen, Alma B; Svendsson, Jens E; Johnsen, Søren P; Riis, Anders; Overgaard, Søren.

In: Acta Orthopaedica (Print Edition), Vol. 81, No. 5, 2010, p. 542-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Pedersen, Alma B ; Svendsson, Jens E ; Johnsen, Søren P ; Riis, Anders ; Overgaard, Søren. / Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry. In: Acta Orthopaedica (Print Edition). 2010 ; Vol. 81, No. 5. pp. 542-7.

Bibtex

@article{83eb9fa001f411e083f5000ea68e967b,
title = "Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry",
abstract = "BACKGROUND AND PURPOSE: There has been a limited amount of research on risk factors for revision due to infection following total hip arthroplasty (THA), probably due to low absolute numbers of revisions. We therefore studied patient- and surgery-related risk factors for revision due to infection after primary THA in a population-based setting. MATERIALS AND METHODS: Using the Danish Hip Arthroplasty Registry, we identified 80,756 primary THAs performed in Denmark between Jan 1, 1995 and Dec 31, 2008. We used Cox regression analysis to compute crude and adjusted relative risk (RR) of revision due to infection. Revision was defined as extraction or exchange of any component due to infection. The median follow-up time was 5 (0–14) years. RESULTS: 597 primary THAs (0.7%) were revised due to infection. Males, patients with any co-morbidity, patients operated due to non-traumatic avascular femoral head necrosis, and patients with long duration of surgery had an increased RR of revision due to infection within the total follow-up time. A tendency of increased RR of revision was found for patients who had received cemented THA without antibiotic and hybrid THA relative to patients with cementless implants. Hip diagnosis and fixation technique were not associated with risk of revision due to infection within 1 year of surgery (short-term risk). INTERPRETATION: We identified several categories of THA patients who had a higher risk of revision due to infection. Further research is required to explain the mechanism underlying this increased risk. More attention should be paid by clinicians to infection prevention strategies in patients with THA, particularly those with increased risk.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, Child, Preschool, Denmark, Female, Follow-Up Studies, Hip Prosthesis, Humans, Male, Middle Aged, Prosthesis Design, Prosthesis-Related Infections, Registries, Reoperation, Risk Factors, Treatment Outcome, Young Adult",
author = "Pedersen, {Alma B} and Svendsson, {Jens E} and Johnsen, {S{\o}ren P} and Anders Riis and S{\o}ren Overgaard",
year = "2010",
doi = "10.3109/17453674.2010.519908",
language = "English",
volume = "81",
pages = "542--7",
journal = "Acta Orthopaedica (Print Edition)",
issn = "1745-3674",
publisher = "TAYLOR & FRANCIS LTD",
number = "5",

}

RIS

TY - JOUR

T1 - Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry

AU - Pedersen, Alma B

AU - Svendsson, Jens E

AU - Johnsen, Søren P

AU - Riis, Anders

AU - Overgaard, Søren

PY - 2010

Y1 - 2010

N2 - BACKGROUND AND PURPOSE: There has been a limited amount of research on risk factors for revision due to infection following total hip arthroplasty (THA), probably due to low absolute numbers of revisions. We therefore studied patient- and surgery-related risk factors for revision due to infection after primary THA in a population-based setting. MATERIALS AND METHODS: Using the Danish Hip Arthroplasty Registry, we identified 80,756 primary THAs performed in Denmark between Jan 1, 1995 and Dec 31, 2008. We used Cox regression analysis to compute crude and adjusted relative risk (RR) of revision due to infection. Revision was defined as extraction or exchange of any component due to infection. The median follow-up time was 5 (0–14) years. RESULTS: 597 primary THAs (0.7%) were revised due to infection. Males, patients with any co-morbidity, patients operated due to non-traumatic avascular femoral head necrosis, and patients with long duration of surgery had an increased RR of revision due to infection within the total follow-up time. A tendency of increased RR of revision was found for patients who had received cemented THA without antibiotic and hybrid THA relative to patients with cementless implants. Hip diagnosis and fixation technique were not associated with risk of revision due to infection within 1 year of surgery (short-term risk). INTERPRETATION: We identified several categories of THA patients who had a higher risk of revision due to infection. Further research is required to explain the mechanism underlying this increased risk. More attention should be paid by clinicians to infection prevention strategies in patients with THA, particularly those with increased risk.

AB - BACKGROUND AND PURPOSE: There has been a limited amount of research on risk factors for revision due to infection following total hip arthroplasty (THA), probably due to low absolute numbers of revisions. We therefore studied patient- and surgery-related risk factors for revision due to infection after primary THA in a population-based setting. MATERIALS AND METHODS: Using the Danish Hip Arthroplasty Registry, we identified 80,756 primary THAs performed in Denmark between Jan 1, 1995 and Dec 31, 2008. We used Cox regression analysis to compute crude and adjusted relative risk (RR) of revision due to infection. Revision was defined as extraction or exchange of any component due to infection. The median follow-up time was 5 (0–14) years. RESULTS: 597 primary THAs (0.7%) were revised due to infection. Males, patients with any co-morbidity, patients operated due to non-traumatic avascular femoral head necrosis, and patients with long duration of surgery had an increased RR of revision due to infection within the total follow-up time. A tendency of increased RR of revision was found for patients who had received cemented THA without antibiotic and hybrid THA relative to patients with cementless implants. Hip diagnosis and fixation technique were not associated with risk of revision due to infection within 1 year of surgery (short-term risk). INTERPRETATION: We identified several categories of THA patients who had a higher risk of revision due to infection. Further research is required to explain the mechanism underlying this increased risk. More attention should be paid by clinicians to infection prevention strategies in patients with THA, particularly those with increased risk.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Arthroplasty, Replacement, Hip

KW - Child, Preschool

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Hip Prosthesis

KW - Humans

KW - Male

KW - Middle Aged

KW - Prosthesis Design

KW - Prosthesis-Related Infections

KW - Registries

KW - Reoperation

KW - Risk Factors

KW - Treatment Outcome

KW - Young Adult

U2 - 10.3109/17453674.2010.519908

DO - 10.3109/17453674.2010.519908

M3 - Journal article

C2 - 20860453

VL - 81

SP - 542

EP - 547

JO - Acta Orthopaedica (Print Edition)

JF - Acta Orthopaedica (Print Edition)

SN - 1745-3674

IS - 5

ER -