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Anders Hammerich Riis

Prospective study of time to pregnancy and adverse birth outcomes

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Standard

Prospective study of time to pregnancy and adverse birth outcomes. / Wise, Lauren A; Mikkelsen, Ellen M; Sørensen, Henrik Toft et al.

In: Fertility and Sterility, Vol. 103, No. 4, 04.2015, p. 1065-1073.e2.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Wise, LA, Mikkelsen, EM, Sørensen, HT, Rothman, KJ, Hahn, KA, Riis, AH & Hatch, EE 2015, 'Prospective study of time to pregnancy and adverse birth outcomes', Fertility and Sterility, vol. 103, no. 4, pp. 1065-1073.e2. https://doi.org/10.1016/j.fertnstert.2015.01.024

APA

Wise, L. A., Mikkelsen, E. M., Sørensen, H. T., Rothman, K. J., Hahn, K. A., Riis, A. H., & Hatch, E. E. (2015). Prospective study of time to pregnancy and adverse birth outcomes. Fertility and Sterility, 103(4), 1065-1073.e2. https://doi.org/10.1016/j.fertnstert.2015.01.024

CBE

MLA

Wise, Lauren A et al. "Prospective study of time to pregnancy and adverse birth outcomes". Fertility and Sterility. 2015, 103(4). 1065-1073.e2. https://doi.org/10.1016/j.fertnstert.2015.01.024

Vancouver

Wise LA, Mikkelsen EM, Sørensen HT, Rothman KJ, Hahn KA, Riis AH et al. Prospective study of time to pregnancy and adverse birth outcomes. Fertility and Sterility. 2015 Apr;103(4):1065-1073.e2. doi: 10.1016/j.fertnstert.2015.01.024

Author

Wise, Lauren A ; Mikkelsen, Ellen M ; Sørensen, Henrik Toft et al. / Prospective study of time to pregnancy and adverse birth outcomes. In: Fertility and Sterility. 2015 ; Vol. 103, No. 4. pp. 1065-1073.e2.

Bibtex

@article{4596c5d3f1284efc9dc4842753042716,
title = "Prospective study of time to pregnancy and adverse birth outcomes",
abstract = "OBJECTIVE: To investigate the association between time to pregnancy (TTP) and adverse birth outcomes.DESIGN: Prospective cohort study.SETTING: Not applicable.PATIENT(S): A total of 3,521 singletons born to women aged 18-40 years at cohort entry.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Selected birth outcomes, including preterm birth (PTB, <37 weeks' gestation), low birth weight (<2,500 g), small for gestational age, large for gestational age, and placental disorders, ascertained from the Danish Medical Birth Registry and Danish National Registry of Patients. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using log-binomial regression, with adjustment for potential confounders and fertility treatment.RESULT(S): Multivariable RRs for PTB in relation to TTP of 3-5, 6-11, and ≥12 vs. <3 cycles were 1.59 (95% CI 0.94-2.69), 0.85 (95% CI 0.48-1.50), and 1.57 (95% CI 0.93-2.65). The association was slightly stronger for spontaneous PTB (TTP ≥12 vs. <3 cycles: RR 1.69, 95% CI 0.84-3.42) than for medically indicated PTB (RR 1.39, 95% CI 0.62-3.12). Longer TTPs (≥12 cycles) were associated with increased risks of low birth weight (RR 1.80, 95% CI 0.97-3.35), cesarean delivery (RR 1.64, 95% CI 1.27-2.12), placental disorders (RR 2.21, 95% CI 1.07-4.56), ischemic placental disease (RR 1.56, 95% CI 0.99-2.44), pre-eclampsia (RR 1.45, 95% CI 0.79-2.65), and postpartum hemorrhage (RR 1.58, CI 1.14-2.19), and decreased risks of macrosomia (≥4,500 g; RR 0.63, 95% CI 0.35-1.13) and large for gestational age (RR 0.76, 95% CI 0.58-1.00). Longer TTP showed little association with small for gestational age.CONCLUSION(S): In a prospective cohort study of Danish pregnancy planners, delayed conception was a marker for adverse birth outcomes, after accounting for fertility treatment.",
keywords = "Adolescent, Adult, Cohort Studies, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Placenta Diseases, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Premature Birth, Time-to-Pregnancy, Young Adult",
author = "Wise, {Lauren A} and Mikkelsen, {Ellen M} and S{\o}rensen, {Henrik Toft} and Rothman, {Kenneth J} and Hahn, {Kristen A} and Riis, {Anders H} and Hatch, {Elizabeth E}",
note = "Copyright {\textcopyright} 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.",
year = "2015",
month = apr,
doi = "10.1016/j.fertnstert.2015.01.024",
language = "English",
volume = "103",
pages = "1065--1073.e2",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Prospective study of time to pregnancy and adverse birth outcomes

AU - Wise, Lauren A

AU - Mikkelsen, Ellen M

AU - Sørensen, Henrik Toft

AU - Rothman, Kenneth J

AU - Hahn, Kristen A

AU - Riis, Anders H

AU - Hatch, Elizabeth E

N1 - Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PY - 2015/4

Y1 - 2015/4

N2 - OBJECTIVE: To investigate the association between time to pregnancy (TTP) and adverse birth outcomes.DESIGN: Prospective cohort study.SETTING: Not applicable.PATIENT(S): A total of 3,521 singletons born to women aged 18-40 years at cohort entry.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Selected birth outcomes, including preterm birth (PTB, <37 weeks' gestation), low birth weight (<2,500 g), small for gestational age, large for gestational age, and placental disorders, ascertained from the Danish Medical Birth Registry and Danish National Registry of Patients. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using log-binomial regression, with adjustment for potential confounders and fertility treatment.RESULT(S): Multivariable RRs for PTB in relation to TTP of 3-5, 6-11, and ≥12 vs. <3 cycles were 1.59 (95% CI 0.94-2.69), 0.85 (95% CI 0.48-1.50), and 1.57 (95% CI 0.93-2.65). The association was slightly stronger for spontaneous PTB (TTP ≥12 vs. <3 cycles: RR 1.69, 95% CI 0.84-3.42) than for medically indicated PTB (RR 1.39, 95% CI 0.62-3.12). Longer TTPs (≥12 cycles) were associated with increased risks of low birth weight (RR 1.80, 95% CI 0.97-3.35), cesarean delivery (RR 1.64, 95% CI 1.27-2.12), placental disorders (RR 2.21, 95% CI 1.07-4.56), ischemic placental disease (RR 1.56, 95% CI 0.99-2.44), pre-eclampsia (RR 1.45, 95% CI 0.79-2.65), and postpartum hemorrhage (RR 1.58, CI 1.14-2.19), and decreased risks of macrosomia (≥4,500 g; RR 0.63, 95% CI 0.35-1.13) and large for gestational age (RR 0.76, 95% CI 0.58-1.00). Longer TTP showed little association with small for gestational age.CONCLUSION(S): In a prospective cohort study of Danish pregnancy planners, delayed conception was a marker for adverse birth outcomes, after accounting for fertility treatment.

AB - OBJECTIVE: To investigate the association between time to pregnancy (TTP) and adverse birth outcomes.DESIGN: Prospective cohort study.SETTING: Not applicable.PATIENT(S): A total of 3,521 singletons born to women aged 18-40 years at cohort entry.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Selected birth outcomes, including preterm birth (PTB, <37 weeks' gestation), low birth weight (<2,500 g), small for gestational age, large for gestational age, and placental disorders, ascertained from the Danish Medical Birth Registry and Danish National Registry of Patients. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using log-binomial regression, with adjustment for potential confounders and fertility treatment.RESULT(S): Multivariable RRs for PTB in relation to TTP of 3-5, 6-11, and ≥12 vs. <3 cycles were 1.59 (95% CI 0.94-2.69), 0.85 (95% CI 0.48-1.50), and 1.57 (95% CI 0.93-2.65). The association was slightly stronger for spontaneous PTB (TTP ≥12 vs. <3 cycles: RR 1.69, 95% CI 0.84-3.42) than for medically indicated PTB (RR 1.39, 95% CI 0.62-3.12). Longer TTPs (≥12 cycles) were associated with increased risks of low birth weight (RR 1.80, 95% CI 0.97-3.35), cesarean delivery (RR 1.64, 95% CI 1.27-2.12), placental disorders (RR 2.21, 95% CI 1.07-4.56), ischemic placental disease (RR 1.56, 95% CI 0.99-2.44), pre-eclampsia (RR 1.45, 95% CI 0.79-2.65), and postpartum hemorrhage (RR 1.58, CI 1.14-2.19), and decreased risks of macrosomia (≥4,500 g; RR 0.63, 95% CI 0.35-1.13) and large for gestational age (RR 0.76, 95% CI 0.58-1.00). Longer TTP showed little association with small for gestational age.CONCLUSION(S): In a prospective cohort study of Danish pregnancy planners, delayed conception was a marker for adverse birth outcomes, after accounting for fertility treatment.

KW - Adolescent

KW - Adult

KW - Cohort Studies

KW - Female

KW - Humans

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Infant, Small for Gestational Age

KW - Placenta Diseases

KW - Pregnancy

KW - Pregnancy Complications

KW - Pregnancy Outcome

KW - Premature Birth

KW - Time-to-Pregnancy

KW - Young Adult

U2 - 10.1016/j.fertnstert.2015.01.024

DO - 10.1016/j.fertnstert.2015.01.024

M3 - Journal article

C2 - 25707334

VL - 103

SP - 1065-1073.e2

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 4

ER -