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Anders Hammerich Riis

Impact of diabetes and poor glycaemic control on risk of bacteraemia with haemolytic streptococci groups A, B, and G

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  • Klinisk Epidemiologisk Afdeling, Aalborg
  • Department of Clinical Epidemiology
  • Klinisk Mikrobiologisk Afdeling, Aalborg
BACKGROUND: Diabetes has been associated with bacteraemia due to haemolytic streptococci but epidemiological evidence is limited. METHODS: We conducted a 15-year population-based case-control study of all adults with first-time bacteraemia with groups A, B, and G haemolytic streptococci and matched population controls. The study setting was Northern Denmark between 1992 and 2006. We computed odds ratios (ORs) for streptococcal bacteraemia according to diabetes and glycaemic control, using regression analysis for confounder adjustment. RESULTS: We identified 397 adult patients with bacteraemia due to haemolytic streptococci (median age 67 years, 51% women), of which 63 (17%) had diabetes. Persons with diabetes had a 2.1-fold increased risk of streptococcal bacteraemia compared with population controls (adjusted odds ratio (OR) 2.1; 95% confidence interval (CI), 1.5-2.9). For persons with type 1 diabetes, the adjusted OR was 14.8 (2.4-91.2). Longer diabetes duration and poor glycaemic control conferred higher risk estimates: adjusted OR 1.5 (0.8-3.0) for HbA(1c) level
Original languageEnglish
JournalJournal of Infection
Pages (from-to)8-16
Number of pages9
Publication statusPublished - 2011

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