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Anders Hammerich Riis

Folic acid supplementation and fecundability: a Danish prospective cohort study

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DOI

  • H T Cueto, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus Nord, Denmark.
  • ,
  • A H Riis
  • E E Hatch, Department of Epidemiology, Boston University School of Public Health, Boston, MA, 617857, USA.
  • ,
  • L A Wise, Department of Epidemiology, Boston University School of Public Health, Boston, MA, 617857, USA.
  • ,
  • K J Rothman, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus Nord, Denmark.
  • ,
  • Henrik Toft Sørensen
  • Ellen Margrethe Mikkelsen

BACKGROUND/OBJECTIVES: Periconceptional folic acid (FA) supplementation reduces the risk of neural tube defects and has been associated with ovulatory function. However, only two studies have associated supplementation with multivitamins (MVs) that contained FA with increased pregnancy rates. We aimed to examine the association between FA supplementation (obtained either through single FA tablets or through MVs) and fecundability.

SUBJECTS/METHODS: A prospective cohort study of 3895 Danish women who were planning a pregnancy between 2007 and 2011. We estimated fecundability ratios (FRs) and 95% confidence intervals (CIs) in relation to FA supplementation (either through single FA tablets or MV) using a proportional probabilities regression model, with adjustment for potential socio-demographic, reproductive and lifestyle confounders. In stratified analyses, we also estimated FR with 95% CI in relation to FA supplementation for women with regular and irregular cycles, respectively, and for women with short (<27 days), medium (27-29 days) and long cycles (⩾30 days), respectively.

RESULTS: FA supplementation was associated with increased fecundability (FR=1.15, 95% CI=1.06-1.25), compared with non-use. The adjusted FRs for FA supplement use relative to non-use were 1.35 (95% CI=1.12-1.65) and 1.11 (95% CI=1.01-1.22) for women with irregular and regular cycles, respectively, and 1.36 (95% CI=0.95-1.95), 1.10 (95% CI=0.98-1.22) and 1.24 (95% CI=1.10-1.41) for women with short (<27 days), medium (27-29 days) and long cycles (⩾30 days), respectively.

CONCLUSIONS: FA supplementation was associated with increased fecundability, and this association appeared to be stronger among women with irregular cycles and among women with either short or long cycle length.

Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume70
Issue1
Pages (from-to)66-71
Number of pages6
ISSN0954-3007
DOIs
Publication statusPublished - Jan 2016

    Research areas

  • Adult, Denmark, Dietary Supplements, Female, Fertility, Folic Acid, Humans, Menstrual Cycle, Pregnancy, Pregnancy Rate, Prospective Studies, Reproduction, Vitamins, Journal Article

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