Anders Hammerich Riis

Antipsychotic drugs and short-term mortality after peptic ulcer perforation: A population-based cohort study.

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Antipsychotic drugs and short-term mortality after peptic ulcer perforation: A population-based cohort study. / Christiansen, Christian; Christensen, Steffen; Riis, Anders et al.

In: Alimentary Pharmacology and Therapeutics, Vol. 28, No. 7, 2008, p. 895-902.

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@article{a0eeb7d074fd11ddb7fc000ea68e967b,
title = "Antipsychotic drugs and short-term mortality after peptic ulcer perforation: A population-based cohort study.",
abstract = "Background Peptic ulcer perforation is a serious surgical emergency with a substantial short-term mortality, but the influence of antipsychotic drug use on the prognosis remains unknown. Aim To examine the association between antipsychotic drug use and 30-day mortality following peptic ulcer perforation. Methods This cohort study comprised 2,033 patients with a first-time hospitalization with peptic ulcer perforation, in Northern Denmark, between 1991 and 2004. Data on preadmission use of antipsychotics and other medications, psychiatric disease, other comorbidities, and mortality were obtained through population-based medical databases. We used Cox regression analyses to compute adjusted mortality rate ratios (MRRs). Results 116 (5.7%) patients with peptic ulcer perforation were current users of antipsychotic drugs at the time of hospital admission and 205 (10.1%) were former users. The overall 30-day mortality was 27%. Among current users of antipsychotics 30-day mortality was 39%. The adjusted 30-day MRR for current users of antipsychotic drugs compared with non-users was 1.7 (95%CI 1.2-2.3). Former use was not a predictor of mortality. The increase in mortality was equal in users of conventional and atypical antipsychotics. Conclusion Use of antipsychotic drugs is associated with substantially increased mortality following peptic ulcer perforation.",
author = "Christian Christiansen and Steffen Christensen and Anders Riis and Thomsen, {Reimar Niels Wernich} and Johnsen, {S{\o}ren Paaske} and T{\o}nnesen, {Else Kirstine} and S{\o}rensen, {Henrik Toft}",
year = "2008",
doi = "10.1111/j.1365-2036.2008.03803.x",
language = "English",
volume = "28",
pages = "895--902",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "7",

}

RIS

TY - JOUR

T1 - Antipsychotic drugs and short-term mortality after peptic ulcer perforation: A population-based cohort study.

AU - Christiansen, Christian

AU - Christensen, Steffen

AU - Riis, Anders

AU - Thomsen, Reimar Niels Wernich

AU - Johnsen, Søren Paaske

AU - Tønnesen, Else Kirstine

AU - Sørensen, Henrik Toft

PY - 2008

Y1 - 2008

N2 - Background Peptic ulcer perforation is a serious surgical emergency with a substantial short-term mortality, but the influence of antipsychotic drug use on the prognosis remains unknown. Aim To examine the association between antipsychotic drug use and 30-day mortality following peptic ulcer perforation. Methods This cohort study comprised 2,033 patients with a first-time hospitalization with peptic ulcer perforation, in Northern Denmark, between 1991 and 2004. Data on preadmission use of antipsychotics and other medications, psychiatric disease, other comorbidities, and mortality were obtained through population-based medical databases. We used Cox regression analyses to compute adjusted mortality rate ratios (MRRs). Results 116 (5.7%) patients with peptic ulcer perforation were current users of antipsychotic drugs at the time of hospital admission and 205 (10.1%) were former users. The overall 30-day mortality was 27%. Among current users of antipsychotics 30-day mortality was 39%. The adjusted 30-day MRR for current users of antipsychotic drugs compared with non-users was 1.7 (95%CI 1.2-2.3). Former use was not a predictor of mortality. The increase in mortality was equal in users of conventional and atypical antipsychotics. Conclusion Use of antipsychotic drugs is associated with substantially increased mortality following peptic ulcer perforation.

AB - Background Peptic ulcer perforation is a serious surgical emergency with a substantial short-term mortality, but the influence of antipsychotic drug use on the prognosis remains unknown. Aim To examine the association between antipsychotic drug use and 30-day mortality following peptic ulcer perforation. Methods This cohort study comprised 2,033 patients with a first-time hospitalization with peptic ulcer perforation, in Northern Denmark, between 1991 and 2004. Data on preadmission use of antipsychotics and other medications, psychiatric disease, other comorbidities, and mortality were obtained through population-based medical databases. We used Cox regression analyses to compute adjusted mortality rate ratios (MRRs). Results 116 (5.7%) patients with peptic ulcer perforation were current users of antipsychotic drugs at the time of hospital admission and 205 (10.1%) were former users. The overall 30-day mortality was 27%. Among current users of antipsychotics 30-day mortality was 39%. The adjusted 30-day MRR for current users of antipsychotic drugs compared with non-users was 1.7 (95%CI 1.2-2.3). Former use was not a predictor of mortality. The increase in mortality was equal in users of conventional and atypical antipsychotics. Conclusion Use of antipsychotic drugs is associated with substantially increased mortality following peptic ulcer perforation.

U2 - 10.1111/j.1365-2036.2008.03803.x

DO - 10.1111/j.1365-2036.2008.03803.x

M3 - Journal article

C2 - 18637098

VL - 28

SP - 895

EP - 902

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 7

ER -