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Anders Hammerich Riis

Alcohol consumption and fecundability: prospective Danish cohort study

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Alcohol consumption and fecundability : prospective Danish cohort study. / Mikkelsen, Ellen M; Hammerich Riis, Anders; Wise, Lauren A et al.

In: B M J (Online), Vol. 354, 2016, p. i4262.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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APA

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Mikkelsen EM, Hammerich Riis A, Wise LA, Hatch EE, Rothman KJ, Cueto HT, Sørensen HT. 2016. Alcohol consumption and fecundability: prospective Danish cohort study. B M J (Online). 354:i4262.

MLA

Vancouver

Mikkelsen EM, Hammerich Riis A, Wise LA, Hatch EE, Rothman KJ, Cueto HT et al. Alcohol consumption and fecundability: prospective Danish cohort study. B M J (Online). 2016;354:i4262.

Author

Mikkelsen, Ellen M ; Hammerich Riis, Anders ; Wise, Lauren A et al. / Alcohol consumption and fecundability : prospective Danish cohort study. In: B M J (Online). 2016 ; Vol. 354. pp. i4262.

Bibtex

@article{dba3b62bcb1e4613a75ee707624836f0,
title = "Alcohol consumption and fecundability: prospective Danish cohort study",
abstract = "OBJECTIVE: To investigate to what extent alcohol consumption affects female fecundability.DESIGN: Prospective cohort study.SETTING: Denmark, 1 June 2007 to 5 January 2016.PARTICIPANTS: 6120 female Danish residents, aged 21-45 years, in a stable relationship with a male partner, who were trying to conceive and not receiving fertility treatment.MAIN OUTCOME MEASURES: Alcohol consumption was self reported as beer (330 mL bottles), red or white wine (120 mL glasses), dessert wine (50 mL glasses), and spirits (20 mL) and categorized in standard servings per week (none, 1-3, 4-7, 8-13, and ≥14). Participants contributed menstrual cycles at risk until the report of pregnancy, start of fertility treatment, loss to follow-up, or end of observation (maximum 12 menstrual cycles). A proportional probability regression model was used to estimate fecundability ratios (cycle specific probability of conception among exposed women divided by that among unexposed women).RESULTS: 4210 (69%) participants achieved a pregnancy during follow-up. Median alcohol intake was 2.0 (interquartile range 0-3.5) servings per week. Compared with no alcohol consumption, the adjusted fecundability ratios for alcohol consumption of 1-3, 4-7, 8-13, and 14 or more servings per week were 0.97 (95% confidence interval 0.91 to 1.03), 1.01 (0.93 to 1.10), 1.01 (0.87 to 1.16) and 0.82 (0.60 to 1.12), respectively. Compared with no alcohol intake, the adjusted fecundability ratios for women who consumed only wine (≥3 servings), beer (≥3 servings), or spirits (≥2 servings) were 1.05 (0.91 to1.21), 0.92 (0.65 to 1.29), and 0.85 (0.61 to 1.17), respectively. The data did not distinguish between regular and binge drinking, which may be important if large amounts of alcohol are consumed during the fertile window.CONCLUSION: Consumption of less than 14 servings of alcohol per week seemed to have no discernible effect on fertility. No appreciable difference in fecundability was observed by level of consumption of beer and wine.",
keywords = "Journal Article",
author = "Mikkelsen, {Ellen M} and {Hammerich Riis}, Anders and Wise, {Lauren A} and Hatch, {Elizabeth E} and Rothman, {Kenneth J} and Cueto, {Heidi Theresa} and S{\o}rensen, {Henrik Toft}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2016",
language = "English",
volume = "354",
pages = "i4262",
journal = "B M J (Online)",
issn = "1756-1833",
publisher = "B M J Group",

}

RIS

TY - JOUR

T1 - Alcohol consumption and fecundability

T2 - prospective Danish cohort study

AU - Mikkelsen, Ellen M

AU - Hammerich Riis, Anders

AU - Wise, Lauren A

AU - Hatch, Elizabeth E

AU - Rothman, Kenneth J

AU - Cueto, Heidi Theresa

AU - Sørensen, Henrik Toft

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: To investigate to what extent alcohol consumption affects female fecundability.DESIGN: Prospective cohort study.SETTING: Denmark, 1 June 2007 to 5 January 2016.PARTICIPANTS: 6120 female Danish residents, aged 21-45 years, in a stable relationship with a male partner, who were trying to conceive and not receiving fertility treatment.MAIN OUTCOME MEASURES: Alcohol consumption was self reported as beer (330 mL bottles), red or white wine (120 mL glasses), dessert wine (50 mL glasses), and spirits (20 mL) and categorized in standard servings per week (none, 1-3, 4-7, 8-13, and ≥14). Participants contributed menstrual cycles at risk until the report of pregnancy, start of fertility treatment, loss to follow-up, or end of observation (maximum 12 menstrual cycles). A proportional probability regression model was used to estimate fecundability ratios (cycle specific probability of conception among exposed women divided by that among unexposed women).RESULTS: 4210 (69%) participants achieved a pregnancy during follow-up. Median alcohol intake was 2.0 (interquartile range 0-3.5) servings per week. Compared with no alcohol consumption, the adjusted fecundability ratios for alcohol consumption of 1-3, 4-7, 8-13, and 14 or more servings per week were 0.97 (95% confidence interval 0.91 to 1.03), 1.01 (0.93 to 1.10), 1.01 (0.87 to 1.16) and 0.82 (0.60 to 1.12), respectively. Compared with no alcohol intake, the adjusted fecundability ratios for women who consumed only wine (≥3 servings), beer (≥3 servings), or spirits (≥2 servings) were 1.05 (0.91 to1.21), 0.92 (0.65 to 1.29), and 0.85 (0.61 to 1.17), respectively. The data did not distinguish between regular and binge drinking, which may be important if large amounts of alcohol are consumed during the fertile window.CONCLUSION: Consumption of less than 14 servings of alcohol per week seemed to have no discernible effect on fertility. No appreciable difference in fecundability was observed by level of consumption of beer and wine.

AB - OBJECTIVE: To investigate to what extent alcohol consumption affects female fecundability.DESIGN: Prospective cohort study.SETTING: Denmark, 1 June 2007 to 5 January 2016.PARTICIPANTS: 6120 female Danish residents, aged 21-45 years, in a stable relationship with a male partner, who were trying to conceive and not receiving fertility treatment.MAIN OUTCOME MEASURES: Alcohol consumption was self reported as beer (330 mL bottles), red or white wine (120 mL glasses), dessert wine (50 mL glasses), and spirits (20 mL) and categorized in standard servings per week (none, 1-3, 4-7, 8-13, and ≥14). Participants contributed menstrual cycles at risk until the report of pregnancy, start of fertility treatment, loss to follow-up, or end of observation (maximum 12 menstrual cycles). A proportional probability regression model was used to estimate fecundability ratios (cycle specific probability of conception among exposed women divided by that among unexposed women).RESULTS: 4210 (69%) participants achieved a pregnancy during follow-up. Median alcohol intake was 2.0 (interquartile range 0-3.5) servings per week. Compared with no alcohol consumption, the adjusted fecundability ratios for alcohol consumption of 1-3, 4-7, 8-13, and 14 or more servings per week were 0.97 (95% confidence interval 0.91 to 1.03), 1.01 (0.93 to 1.10), 1.01 (0.87 to 1.16) and 0.82 (0.60 to 1.12), respectively. Compared with no alcohol intake, the adjusted fecundability ratios for women who consumed only wine (≥3 servings), beer (≥3 servings), or spirits (≥2 servings) were 1.05 (0.91 to1.21), 0.92 (0.65 to 1.29), and 0.85 (0.61 to 1.17), respectively. The data did not distinguish between regular and binge drinking, which may be important if large amounts of alcohol are consumed during the fertile window.CONCLUSION: Consumption of less than 14 servings of alcohol per week seemed to have no discernible effect on fertility. No appreciable difference in fecundability was observed by level of consumption of beer and wine.

KW - Journal Article

M3 - Journal article

C2 - 27581754

VL - 354

SP - i4262

JO - B M J (Online)

JF - B M J (Online)

SN - 1756-1833

ER -