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Allan Hansen

MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding

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Standard

MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding. / Hansen, Allan K; Brooks, David J; Borghammer, Per.
In: Molecular Imaging and Biology, 10.11.2017.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Hansen, AK, Brooks, DJ & Borghammer, P 2017, 'MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding', Molecular Imaging and Biology. https://doi.org/10.1007/s11307-017-1143-1

APA

Hansen, A. K., Brooks, D. J., & Borghammer, P. (2017). MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding. Molecular Imaging and Biology. https://doi.org/10.1007/s11307-017-1143-1

CBE

Hansen AK, Brooks DJ, Borghammer P. 2017. MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding. Molecular Imaging and Biology. https://doi.org/10.1007/s11307-017-1143-1

MLA

Hansen, Allan K, David J Brooks, and Per Borghammer. "MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding". Molecular Imaging and Biology. 2017. https://doi.org/10.1007/s11307-017-1143-1

Vancouver

Hansen AK, Brooks DJ, Borghammer P. MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding. Molecular Imaging and Biology. 2017 Nov 10. Epub 2017 Nov 10. doi: 10.1007/s11307-017-1143-1

Author

Hansen, Allan K ; Brooks, David J ; Borghammer, Per. / MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding. In: Molecular Imaging and Biology. 2017.

Bibtex

@article{4a5b7d9e0c5240b88162aec601e626d1,
title = "MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding",
abstract = "PURPOSE: Recent evidence suggests that the tau radiotracer [(18)F]THK-5351 displays high affinity for the monoamine oxidase type B (MAO-B) enzyme. Utilizing another tau-tracer, flortaucipir ([(18)F]AV-1451), we previously reported that non-demented Parkinson's disease patients show off-target binding in subcortical structures, but no appreciable cortical uptake. However, 59 % of these patients were receiving MAO-B inhibitors at the time of their scan. Here, we retrospectively investigated if MAO-B inhibitors in clinical doses affect flortaucipir binding.PROCEDURES: We compared the standard uptake values of flortaucipir at regional and voxel levels in Parkinson's disease patients who received MAO-B inhibitors with those who did not.RESULTS: Sixteen of 27 Parkinson's disease patients received MAO-B inhibitors at the time of scan. We found no significant flortaucipir uptake differences between the groups at voxel or regional levels.CONCLUSION: Use of MAO-B inhibitors at pharmaceutical levels did not significantly affect flortaucipir binding. Thus, MAO-B does not appear to be a significant binding target of flortaucipir.",
keywords = "Journal Article",
author = "Hansen, {Allan K} and Brooks, {David J} and Per Borghammer",
year = "2017",
month = nov,
day = "10",
doi = "10.1007/s11307-017-1143-1",
language = "English",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding

AU - Hansen, Allan K

AU - Brooks, David J

AU - Borghammer, Per

PY - 2017/11/10

Y1 - 2017/11/10

N2 - PURPOSE: Recent evidence suggests that the tau radiotracer [(18)F]THK-5351 displays high affinity for the monoamine oxidase type B (MAO-B) enzyme. Utilizing another tau-tracer, flortaucipir ([(18)F]AV-1451), we previously reported that non-demented Parkinson's disease patients show off-target binding in subcortical structures, but no appreciable cortical uptake. However, 59 % of these patients were receiving MAO-B inhibitors at the time of their scan. Here, we retrospectively investigated if MAO-B inhibitors in clinical doses affect flortaucipir binding.PROCEDURES: We compared the standard uptake values of flortaucipir at regional and voxel levels in Parkinson's disease patients who received MAO-B inhibitors with those who did not.RESULTS: Sixteen of 27 Parkinson's disease patients received MAO-B inhibitors at the time of scan. We found no significant flortaucipir uptake differences between the groups at voxel or regional levels.CONCLUSION: Use of MAO-B inhibitors at pharmaceutical levels did not significantly affect flortaucipir binding. Thus, MAO-B does not appear to be a significant binding target of flortaucipir.

AB - PURPOSE: Recent evidence suggests that the tau radiotracer [(18)F]THK-5351 displays high affinity for the monoamine oxidase type B (MAO-B) enzyme. Utilizing another tau-tracer, flortaucipir ([(18)F]AV-1451), we previously reported that non-demented Parkinson's disease patients show off-target binding in subcortical structures, but no appreciable cortical uptake. However, 59 % of these patients were receiving MAO-B inhibitors at the time of their scan. Here, we retrospectively investigated if MAO-B inhibitors in clinical doses affect flortaucipir binding.PROCEDURES: We compared the standard uptake values of flortaucipir at regional and voxel levels in Parkinson's disease patients who received MAO-B inhibitors with those who did not.RESULTS: Sixteen of 27 Parkinson's disease patients received MAO-B inhibitors at the time of scan. We found no significant flortaucipir uptake differences between the groups at voxel or regional levels.CONCLUSION: Use of MAO-B inhibitors at pharmaceutical levels did not significantly affect flortaucipir binding. Thus, MAO-B does not appear to be a significant binding target of flortaucipir.

KW - Journal Article

U2 - 10.1007/s11307-017-1143-1

DO - 10.1007/s11307-017-1143-1

M3 - Journal article

C2 - 29127552

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

ER -