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Allan Hansen

Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study

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Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. / Parbo, Peter; Ismail, Rola; Sommerauer, Michael et al.

In: Neurobiology of Disease, Vol. 117, 2018, p. 211-216.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Parbo, P, Ismail, R, Sommerauer, M, Stokholm, MG, Hansen, AK, Hansen, KV, Amidi, A, Schaldemose, JL, Gottrup, H, Brændgaard, H, Eskildsen, SF, Borghammer, P, Hinz, R, Aanerud, J & Brooks, DJ 2018, 'Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study', Neurobiology of Disease, vol. 117, pp. 211-216. https://doi.org/10.1016/j.nbd.2018.06.004

APA

Parbo, P., Ismail, R., Sommerauer, M., Stokholm, M. G., Hansen, A. K., Hansen, K. V., Amidi, A., Schaldemose, J. L., Gottrup, H., Brændgaard, H., Eskildsen, S. F., Borghammer, P., Hinz, R., Aanerud, J., & Brooks, D. J. (2018). Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of Disease, 117, 211-216. https://doi.org/10.1016/j.nbd.2018.06.004

CBE

Parbo P, Ismail R, Sommerauer M, Stokholm MG, Hansen AK, Hansen KV, Amidi A, Schaldemose JL, Gottrup H, Brændgaard H, et al. 2018. Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of Disease. 117:211-216. https://doi.org/10.1016/j.nbd.2018.06.004

MLA

Parbo, Peter et al. "Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study". Neurobiology of Disease. 2018, 117. 211-216. https://doi.org/10.1016/j.nbd.2018.06.004

Vancouver

Parbo P, Ismail R, Sommerauer M, Stokholm MG, Hansen AK, Hansen KV et al. Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of Disease. 2018;117:211-216. Epub 2018 Jun 11. doi: 10.1016/j.nbd.2018.06.004

Author

Parbo, Peter ; Ismail, Rola ; Sommerauer, Michael et al. / Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. In: Neurobiology of Disease. 2018 ; Vol. 117. pp. 211-216.

Bibtex

@article{c7e0c4e2dd2c4bd6ba61911e91499705,
title = "Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study",
abstract = "OBJECTIVE: Our aim was to assess with positron emission tomography (PET) the temporal and spatial inter-relationships between levels of cortical microglial activation and the aggregated amyloid-β and tau load in mild cognitive impairment (MCI) and early Alzheimer's disease (AD).METHODS: Six clinically probable AD and 20 MCI subjects had inflammation (11C-(R)-PK11195), amyloid (11C-PiB) and tau (18F-flortaucipir) PET, magnetic resonance imaging (MRI) and a neuropsychological assessment. Parametric images of tracer binding were interrogated at a voxel level and by region of interest analyses.RESULTS: 55% of MCI and 83% of AD subjects had a high amyloid-β load. We have previously reported that clusters of correlated amyloid and inflammation levels are present in cortex. Here we found no correlation between levels of inflammation (11C-(R)-PK11195 BPND) and tau (18F-flortaucipir SUVR) or MMSE scores in high amyloid-β cases.INTERPRETATION: While correlated levels of amyloid-β and inflammation can be seen in MCI, we did not detect an association between levels of cortical tau tangles and inflammation in our series of high amyloid-β cases. High levels of inflammation could be seen in amyloid-β positive MCI cases where 18F-flortaucipir signals were low suggesting microglial activation precedes tau tangle formation. Inflammation levels were higher in high amyloid-β MCI than in early AD cases, compatible with it initially playing a protective role.",
author = "Peter Parbo and Rola Ismail and Michael Sommerauer and Stokholm, {Morten G} and Hansen, {Allan K} and Hansen, {Kim V} and Ali Amidi and Schaldemose, {Jeppe L} and Hanne Gottrup and Hans Br{\ae}ndgaard and Eskildsen, {Simon F} and Per Borghammer and Rainer Hinz and Joel Aanerud and Brooks, {David J}",
note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",
year = "2018",
doi = "10.1016/j.nbd.2018.06.004",
language = "English",
volume = "117",
pages = "211--216",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study

AU - Parbo, Peter

AU - Ismail, Rola

AU - Sommerauer, Michael

AU - Stokholm, Morten G

AU - Hansen, Allan K

AU - Hansen, Kim V

AU - Amidi, Ali

AU - Schaldemose, Jeppe L

AU - Gottrup, Hanne

AU - Brændgaard, Hans

AU - Eskildsen, Simon F

AU - Borghammer, Per

AU - Hinz, Rainer

AU - Aanerud, Joel

AU - Brooks, David J

N1 - Copyright © 2017. Published by Elsevier Inc.

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: Our aim was to assess with positron emission tomography (PET) the temporal and spatial inter-relationships between levels of cortical microglial activation and the aggregated amyloid-β and tau load in mild cognitive impairment (MCI) and early Alzheimer's disease (AD).METHODS: Six clinically probable AD and 20 MCI subjects had inflammation (11C-(R)-PK11195), amyloid (11C-PiB) and tau (18F-flortaucipir) PET, magnetic resonance imaging (MRI) and a neuropsychological assessment. Parametric images of tracer binding were interrogated at a voxel level and by region of interest analyses.RESULTS: 55% of MCI and 83% of AD subjects had a high amyloid-β load. We have previously reported that clusters of correlated amyloid and inflammation levels are present in cortex. Here we found no correlation between levels of inflammation (11C-(R)-PK11195 BPND) and tau (18F-flortaucipir SUVR) or MMSE scores in high amyloid-β cases.INTERPRETATION: While correlated levels of amyloid-β and inflammation can be seen in MCI, we did not detect an association between levels of cortical tau tangles and inflammation in our series of high amyloid-β cases. High levels of inflammation could be seen in amyloid-β positive MCI cases where 18F-flortaucipir signals were low suggesting microglial activation precedes tau tangle formation. Inflammation levels were higher in high amyloid-β MCI than in early AD cases, compatible with it initially playing a protective role.

AB - OBJECTIVE: Our aim was to assess with positron emission tomography (PET) the temporal and spatial inter-relationships between levels of cortical microglial activation and the aggregated amyloid-β and tau load in mild cognitive impairment (MCI) and early Alzheimer's disease (AD).METHODS: Six clinically probable AD and 20 MCI subjects had inflammation (11C-(R)-PK11195), amyloid (11C-PiB) and tau (18F-flortaucipir) PET, magnetic resonance imaging (MRI) and a neuropsychological assessment. Parametric images of tracer binding were interrogated at a voxel level and by region of interest analyses.RESULTS: 55% of MCI and 83% of AD subjects had a high amyloid-β load. We have previously reported that clusters of correlated amyloid and inflammation levels are present in cortex. Here we found no correlation between levels of inflammation (11C-(R)-PK11195 BPND) and tau (18F-flortaucipir SUVR) or MMSE scores in high amyloid-β cases.INTERPRETATION: While correlated levels of amyloid-β and inflammation can be seen in MCI, we did not detect an association between levels of cortical tau tangles and inflammation in our series of high amyloid-β cases. High levels of inflammation could be seen in amyloid-β positive MCI cases where 18F-flortaucipir signals were low suggesting microglial activation precedes tau tangle formation. Inflammation levels were higher in high amyloid-β MCI than in early AD cases, compatible with it initially playing a protective role.

U2 - 10.1016/j.nbd.2018.06.004

DO - 10.1016/j.nbd.2018.06.004

M3 - Journal article

C2 - 29902557

VL - 117

SP - 211

EP - 216

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

ER -