Aage Kristian Olsen Alstrup

Monitoring variables affecting positron emission tomography measurements of cerebral blood flow in anaesthetized pigs

Research output: Contribution to conferencePosterResearch

Background: Positron emission tomography (PET) imaging of anaesthetised pig brains is a useful tool in neuroscience. Stable cerebral blood flow (CBF) is essential for PET, since variations can affect the kinetics of several radiotracers. However, the impact of physiological factors regulating CBF is unresolved and therefore knowledge about optimal anaesthesia and monitoring of pigs in PET studies is sparse. The aim of this study was thus to determine if and how physiological variables and length of anaesthesia impacted CBF as measured by PET using [15O]-water in isofluorane-N2O anaesthetized domestic female pigs. Results: We found that low blood pH, high arterial carbon dioxide tension (PaCO2), high heart rate, high body temperature and long anaesthesia time are associated with high CBF in anaesthetized pigs. No associations were noted between CBF and low arterial oxygen tension, haematocrit, systolic and diastolic blood pressure. Conclusions: Our observations indicate that monitoring of pH, PaCO2, heart rate and body temperature are crucial for maintaining stable levels of CBF and thus optimizing PET imaging of molecular mechanisms in the brain of living pig. Furtermore, anaesthesia length should be kept constant during porcine brain PET studies.
Original languageEnglish
Publication year14 Nov 2017
Publication statusPublished - 14 Nov 2017
Event1st Annual Research Meeting - Aarhus Universitet, Aarhus, Denmark
Duration: 14 Nov 201714 Nov 2017

Conference

Conference1st Annual Research Meeting
LocationAarhus Universitet
CountryDenmark
CityAarhus
Period14/11/201714/11/2017

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