Aage Kristian Olsen Alstrup

Kinetic Modelling of Infection Tracers [(18)F]FDG, [(68)Ga]Ga-Citrate, [(11)C]Methionine, and [(11)C]Donepezil in a Porcine Osteomyelitis Model

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DOI

  • Lars Jødal, University of Copenhagen, Department of Veterinary Clinical and Animal Sciences, Frederiksberg C, Copenhagen, Denmark ; kkf@sund.ku.dk.
  • ,
  • Svend B Jensen, c Department of Nuclear Medicine , Aalborg University Hospital , Aalborg , Denmark., Department of Chemistry and Biosciences, Aalborg University, Aalborg, Denmark.
  • ,
  • Ole L Nielsen, University of Copenhagen, Department of Veterinary Clinical and Animal Sciences, Frederiksberg C, Copenhagen, Denmark ; kkf@sund.ku.dk.
  • ,
  • Pia Afzelius, Department of Diagnostic Imaging, North Zealand Hospital, Hillerød, University Hospital of Copenhagen Copenhagen, Denmark.
  • ,
  • Per Borghammer
  • Aage K O Alstrup
  • Søren B Hansen
Introduction. Positron emission tomography (PET) is increasingly applied for infection imaging using [18F]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [18F]FDG and three other PET tracers with relevance for infection imaging. Methods. A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [18F]FDG, [68Ga]Ga-citrate, [11C]methionine, and/or [11C]donepezil, along with blood sampling. For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer. Results. Irreversible uptake was found for [18F]FDG and [68Ga]Ga-citrate; reversible uptake was found for [11C]methionine (two-tissue model) and [11C]donepezil (one-tissue model). The uptake rate for [68Ga]Ga-citrate was slow and diffusion-limited. For the other tracers, the uptake rate was primarily determined by perfusion (flow-limited uptake). Net uptake rate for [18F]FDG and distribution volume for [11C]methionine were significantly higher for infectious lesions than for correspondingly noninfected tissue. For [11C]donepezil in pigs, labelled metabolite products appeared to be important for the analysis. Conclusions. The kinetics of the four studied tracers in infection was characterized. For clinical applications, [18F]FDG remains the first-choice PET tracer. [11C]methionine may have a potential for detecting soft tissue infections. [68Ga]Ga-citrate and [11C]donepezil were not found useful for imaging of osteomyelitis.
Original languageEnglish
JournalContrast Media & Molecular Imaging (Print)
Volume2017
Pages (from-to)9256858
ISSN1555-4309
DOIs
Publication statusPublished - 2017

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